Results 61 to 70 of about 6,277,435 (292)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Actuators, 2023 In the realm of high-speed precision broadcasting, the existing seeder opener proves inadequate for the speed of the seeding operation. We focus on the duckbill opener and employ the quadratic regression orthogonal rotation combination test design method
Weipeng Zhang +9 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Complete Characterization of Resistance Distance for Linear Octagonal Networks
Complexity, 2020 Computing the resistance distance of a network is a fundamental and classical topic. In the aspects of considering the resistances between any two points of the lattice networks, there are many studies associated with the ladder networks and ladderlike ...
Jing Zhao, Jia-Bao Liu, Ali Zafari
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Study of failure mechanism of double-lap joints of steel to FRP by bolt and resin [PDF]
Journal of Structural and Construction Engineering, 2017 In this study, the behavior of joints in two sides of steel coat which are screwed to the composite plate, and joints of two sides of compound steel coat (bolted and bonded) to the composite plate has been studied.
Amir Hossein Zakeri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Study on Muck Pile Shape of Open-Pit Bench Blasting Based on PFC
Shock and Vibration, 2023 To study the influence of different resistance lines and rows delay intervals on the shape of the muck pile and the throwing distance of open-pit bench blasting based on the open-pit bench blasting test, two-dimensional particle flow code (PFC2D) is used
Wenle Gao +4 more
doaj +1 more source
Extremal graphs with diameter 2 for two indices on resistance-distance
Discrete Mathematics, 2019 For a connected graph G , the multiplicative eccentricity resistance-distance ξ R ∗ ( G ) is defined as ξ R ∗ ( G ) = ∑ { v i , v j } ⊆ V ( G ) e ( v i ) ⋅ e ( v j ) R G ( v i , v j ) , where e ( ⋅ ) is the eccentricity of the corresponding vertex and R ...
Yunchao Hong, Zhongxun Zhu, A. Luo
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source