Results 81 to 90 of about 7,571,911 (312)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Complete Characterization of Resistance Distance for Linear Octagonal Networks

Complexity, 2020
Computing the resistance distance of a network is a fundamental and classical topic. In the aspects of considering the resistances between any two points of the lattice networks, there are many studies associated with the ladder networks and ladderlike ...
Jing Zhao, Jia-Bao Liu, Ali Zafari
doaj   +1 more source

Study of failure mechanism of double-lap joints of steel to FRP by bolt and resin [PDF]

Journal of Structural and Construction Engineering, 2017
In this study, the behavior of joints in two sides of steel coat which are screwed to the composite plate, and joints of two sides of compound steel coat (bolted and bonded) to the composite plate has been studied.
Amir Hossein Zakeri, Asghar Vatani Oskoei, Saeed Madani   +2 more
doaj   +1 more source

Extremal Properties of Complex Networks [PDF]

, 2011
We describe the structure of connected graphs with the minimum and maximum average distance, radius, diameter, betweenness centrality, efficiency and resistance distance, given their order and size.
Barmpoutis, Dionysios, Murray, Richard M.   +1 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Study on Muck Pile Shape of Open-Pit Bench Blasting Based on PFC

Shock and Vibration, 2023
To study the influence of different resistance lines and rows delay intervals on the shape of the muck pile and the throwing distance of open-pit bench blasting based on the open-pit bench blasting test, two-dimensional particle flow code (PFC2D) is used
Wenle Gao, Jianwei Zhang, Chenhao Li, Lin Cheng, Penghui Liu   +4 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Role of Resistance Training in Distance Running

Proceedings of Singapore Healthcare, 2010
The main determinants of distance running performance include V̇O 2 max, lactate threshold (LT), and running economy (RE). The conventional way to achieve improvements in these areas is through endurance training due to the principle of training ...
Philip Tan BSc (Sports Science)
doaj   +1 more source