Results 81 to 90 of about 4,242,053 (289)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

La coopération entre concepteurs et tuteurs et l’évolution du rôle du tuteur dans un établissement unimodal d’enseignement à distance

, 2017
In distance education, a separation of roles between course design teams and student support teams are still characteristic of many specialized institutions.
Poellhuber, Bruno, Florent Michelot, Chomienne, Martine, Marie-Noëlle, Fortin, Florent, Michelot, Martine Chomienne, Fortin, Marie-Noëlle, Bruno Poellhuber, Michelot, Florent, Marie-Noëlle Fortin   +9 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Extremal values on the Kirchhoff index of the line graph of trees

Kuwait Journal of Science
The computation of resistance distance and the Kirchhoff index is a classical problem that has been extensively investigated by numerous mathematicians, physicists, and scientists. Consider a simple connected graph G with vertex set V(G) and edge set E(G)
doaj   +1 more source

Graph curvature via resistance distance

Discrete Applied Mathematics
15 pages, 2 ...
Karel Devriendt, Andrea Ottolini, Stefan Steinerberger   +2 more
openaire   +5 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exquisite, apart: remoteness and/as resistance. [PDF]

, 2013
It has become routine to characterise digital art as indicative of an assumed universal shift from ‘traditional’ practic-es towards novel forms of cultural pro-duction, interaction and consumption.
Tiatia, Angela, Antonczak, Laurent, Walker, Charles, Eimke, Andrea, Watkins, Clinton   +4 more
core  

Construction of Ecological Security Patterns Based on Circuit Theory under the Resistance Distance Principle. [PDF]

Int J Environ Res Public Health, 2022
Chen J, Mei Z, Wang B, Wei J.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Exploring A Transactional Distance-Based Management Model To Improve Perception Of Efficacy Within Designated Corporate Collaboration Communities [PDF]

, 2017
Oil and Gas (O&G) companies are adopting blended learning models to move away from traditional face-to-face training programs that are viewed as costly and less efficient.
Workman, Timothy Peter
core