Results 101 to 110 of about 4,242,053 (289)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Exploring the use of distance education technology for lifestyle change

open access: yes, 2011
Obesity affects over 100 million men, women, and children in North America alone and has reached what health professionals deem to be epidemic proportions.
Patrick J. Tierney
core  

Enhancement the Armor Shielding Properties of CF/epoxy Composite by Addition Nanoparticles of Magnetic Iron Oxide

open access: yesMATEC Web of Conferences, 2017
In the present investigation, we prepared two types of CF composites. The first prepared composite sample was CF/epoxy resin composite and the second was CF/epoxy resin / with a different weight ratio of magnetic iron oxide.
Fouda Hany, Ghith Khalid, Guo Lin
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Using Virtual Worlds in Distance Education [PDF]

open access: yes, 2017
This case study examines the effectiveness of 3D Virtual Worlds (VWs) in Distance Education (DE). A series of in-world collaborative learning activities (4 in total) was conducted in the virtual world of Second Life (SL) with 9 DE students from Athabasca
Nteliopoulou, Sofia
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Acquisition of Soft Skills and Affective Outcomes in Online Distance Education: A Secondary School Study

open access: yes, 2008
Canada is facing a shortage of workers skilled in affective outcomes, specifically soft skills. Some fingers are pointing to the primary and secondary institutions for failing to aptly prepare future employees with those skills.
Hertlein, J. L.
core  

Using Simulation-based Practice Labs to Promote Instructional Effectiveness and Community Cohesion in a Blended Distance Nursing Program [PDF]

open access: yes, 2012
An on-site simulation-based practice lab was conducted with 42 students enrolled in a blended distance practical nursing diploma program at the end of their first year of study, prior to their clinical placements.
Walker, Debra
core  

The transitions from distance to online education : Perspectives from the educational management horizon

open access: yes, 2012
In Sweden, higher education has moved away from distance education, including physical meetings, to online education with no physical meetings at all.
Lövqvist, Jeanette   +3 more
core   +2 more sources

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