Results 71 to 80 of about 5,850,611 (258)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of the cir1 disease resistance gene in Arabidopsis thaliana [PDF]

, 2012
Includes bibliographical references.Plants rely on an elaborate multi-layered defence system to perceive and effectively respond to disease causing pathogens.
Diener, Anastashia
core   +1 more source

Evolution of linked avirulence effectors in Leptosphaeria maculans is affected by genomic environment and exposure to resistance genes in host plants [PDF]

, 2010
Brassica napus (canola) cultivars and isolates of the blackleg fungus, Leptosphaeria maculans interact in a ‘gene for gene’ manner whereby plant resistance (R) genes are complementary to pathogen avirulence (Avr) genes.
McDonald, B., Patrick C Brunner, Anton J Cozijnsen, Barbara J. Howlett, Cozijnsen, Anton J., Brunner, PC, van de Wouw, A.P., Howlett, B.J., Brunner, P., Howlett, BJ, Brunner Patrick C., McDonald, BA, James K. Hane, Oliver, R.P., Angela P Van de Wouw, Richard P. Oliver, Hane, James K., Howlett, Barbara J., Brunner, Patrick C., Oliver, Richard P., Richard P Oliver, Bruce A. McDonald, Angela P. Van de Wouw, Hane, JK, Oliver Richard P., Bruce A McDonald, Anton J. Cozijnsen, Brunner, P.C., Cozijnsen, AJ, Howlett, B., Hane, J., Hane James K., Hane, J.K., Barbara J Howlett, McDonald, Bruce A., van de Wouw, AP, Cozijnsen, A., James K Hane, Cozijnsen Anton J., Howlett Barbara J., McDonald Bruce A., Oliver, Richard, McDonald, B.A., Van de Wouw Angela P., Van de Wouw, Angela P., Patrick C. Brunner, Cozijnsen, A.J., Van de Wouw, A., Oliver, RP   +48 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Epidemiological Characteristics, Antibiotic Resistance Patterns and Genomic Analysis of Shigella Isolated in Pudong, Shanghai During 2013–2024

Antibiotics
Background: Shigella spp. are critical pathogens causing diarrheal diseases. This study analyzed the epidemiological characteristics, antimicrobial resistance profiles, virulence factor profiles, and molecular patterns of Shigella isolates in Pudong New ...
Yue Zhang, Xiao Wang, Yanru Liang, Wenqing Wang, Hong Huang, Bowen Yang, Anran Zhang, Yuan Zhuang, Min Chen, Jun Feng, Bing Zhao   +10 more
doaj   +1 more source

Wheat receptor-kinase-like protein Stb6 controls gene-for-gene resistance to fungal pathogen Zymoseptoria tritici [PDF]

, 2018
Deployment of fast-evolving disease-resistance genes is one of the most successful strategies used by plants to fend off pathogens. In gene-for-gene relationships, most cloned disease-resistance genes encode intracellular nucleotide-binding leucine-rich ...
Kanyuka, K., Florence Cambon, Cyrille Saintenac, Andy L. Phillips, Kim E. Hammond-Kosack, Marande, W., Cambon, Florence, William Marande, Stephen J. Powers, Marande, William, Saintenac, Cyrille, Kanyuka, Kostya, Hélène Bergès, Wing-Sham Lee, Rudd, Jason J., Lee, W. S., Powers, Stephen J., Saintennac, C., Berges, Helene, King, R., Thierry Langin, Jason J. Rudd, Cristobal Uauy, Phillips, A. L., Lee, Wing-Sham, Hammond-Kosack, Kim E., Uauy, C., Hammond-Kosack, K. E., Langin, T., Langin, Thierry, Rudd, J. J., Powers, S. J., Phillips, Andy L., Kostya Kanyuka, King, Robert C., Robert C. King, Berges, H., Cambon, F., Uauy, Cristobal   +38 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Occurrence and virulence of wheat yellow rust in Hungary during 1999-2001

Plant Protection Science, 2002
The occurrence and virulence of wheat yellow rust in Hungary was studied in the period of 1999-2001. Yellow rust in Hungary occurred only in traces in 1999, strongly spread and reached epidemic level in Röjtökmuzsaj (West Hungary) in 2000, and the ...
K. Manninger
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek, Darren, Burchmore, Richard J S, Vincent, Isabel M, Watson, David G, Barrett, Michael P, Kamleh, Mohammed A, Woods, Debra J, Wong, Pui Ee   +7 more
core   +4 more sources