Results 61 to 70 of about 4,842,066 (260)

The identification of wheat leaf rust resistance genes and their utilisation value in 42 wheat cultivars

Czech Journal of Genetics and Plant Breeding
Leaf rust is an important wheat disease that considerably reduces the wheat production in most wheat growing regions worldwide. This study aimed to identify leaf rust resistance genes in 42 wheat varieties to find genetic sources with the broadest ...
Xue Li, Zhanhai Kang, Jiaqi Zhang, Sufen Dong, Man Li, Xing Li   +5 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo [PDF]

, 2004
In gene therapy, a clinically relevant therapeutic effect requires long-term expression of the desired gene at a level sufficient to correct or at least alleviate the underlying gene defect.
Pfützner, Wolfgang, Vogel, Jonathan C.
core   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Molecular Markers and Postulation Study of Leaf Rust Resistance Genes in Various Egyptian Wheat Cultivars

Biotechnology Journal International, 2017
The current investigation was carried out at seedling stage under greenhouse condition to: (1) postulate leaf rust resistance genes in ten Egyptian spring wheat cultivars at seedling stage and (2) Verify the presence of resistance genes in the selected cultivars using specific molecular markers linked to leaf rust resistance genes.
Abouzied, Hanaa, Argawy, Eman El, El-Orabey, Walid   +2 more
openaire   +2 more sources

Allocation of the oat powdery mildew resistance gene Pm3 to oat chromosome 1A

, 2021
Besides the mode of inheritance, the knowledge of the chromosome location and allelic relationships are the essentials towards a successful deployment and stacking of divergent disease resistance genes for a given pathogen in breeding programs.
Mohler, Volker, Volker Mohler
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Potential of Lithuanian Oat Genotypes as Sources of Resistance to Blumeria graminis f. sp. avenae

Agriculture
Oat (Avena sativa L.) is a crop of significant economic and nutritional importance; however, its yield and quality can be substantially reduced by fungal diseases, including powdery mildew caused by Blumeria graminis f. sp. avenae (Bga).
Weronika Grzelak, Vida Danytė, Aleksandra Nucia, Andrii Gorash, Remigijus Šmatas, Sylwia Okoń   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Parallel loss-of-function at the RPM1 bacterial resistance locus in Arabidopsis thaliana [PDF]

, 2012
Dimorphism at the Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) locus is well documented in natural populations of Arabidopsis thaliana and has been portrayed as a long-term balanced polymorphism. The haplotype from resistant plants contains
Grant, Murray, Rose, Laura E., Murray Grant, Susanna Atwell, Murray eGrant, Eric B. Holub, Laura Ellen Rose, Holub, E. B., Susanna eAtwell, Laura Rose, Atwell, Susanna, Eric B Holub   +11 more
core   +1 more source