Results 81 to 90 of about 4,842,066 (260)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Virulence of Puccina graminis f.sp. tritici and Postulated Resistance Genes for Stem Rust in Ten Wheat Varieties in Egypt

International Journal of Plant & Soil Science, 2014
Stem rust (Puccina graminis f. sp. tritici) samples were collected from different areas of Egypt during two season 2008/2009 and 2009/2010 growing seasons. The single pustule method of isolation was followed, and the type of infection was recorded as well for each rust samples.
Abou Zeid, M, M. Moussa, Olfat, M. Ragab, Mona, Sherif, S   +3 more
openaire   +3 more sources

Performance and long-term stability of the barley hordothionin gene in multiple transgenic apple lines [PDF]

, 2011
Introduction of sustainable scab resistance in elite apple cultivars is of high importance for apple cultivation when aiming at reducing the use of chemical crop protectants.
Groenwold, R., Remmelt Groenwold, A. Evert J. Walraven, Schaart, J.G., Jan G. Schaart, Hesselink, T., Walraven, A.E.J., Jac T. N. M. Thissen, Krens, F.A., Thamara Hesselink, Frans A. Krens, Thissen, J.T.N.M.   +11 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Adult Plant Resistance in Selected Indian Wheat Cultivars and Postulation of Yellow Rust Resistance Genes

International Journal of Science and Research (IJSR), 2021
Neha Gupta, Subhash Chander Bhardwaj, Neha Batra   +2 more
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Transgenic resistance to pathogens and pests [PDF]

, 2004
Pathogens and pests constantly threaten plants and cause crop losses of significant economic importance for agricultural production worldwide. One way to reduce the damage caused by pathogens and pests is the development of new, resistant cultivars ...
Melander, Margareta
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

SolRgene: an online database to explore disease resistance genes in tuber-bearing Solanum species [PDF]

, 2011
Background The cultivated potato (Solanum tuberosum L.) is an important food crop, but highly susceptible to many pathogens. The major threat to potato production is the Irish famine pathogen Phytophthora infestans, which causes the devastating late ...
Goverse, A., Berloo, R., van, Jacobsen, E., Jacobs, M.M.J., Hoekstra, R., Vosman, B., Visser, R.G.F., Vleeshouwers, V.G.A.A., Champouret, N., Rietman, H., Huigen, D.J., Finkers, H.J., Vissers, M., Bakker, E.H., Budding, D.J., Krenek, P., Pel, M., Erin Bakker, Hendrik Rietman, Richard Finkers, Marcel Visser, Nicolas Champouret, Ralph van Berloo, DirkJan Huigen, Evert Jacobsen, Vivianne GAA Vleeshouwers, Aska Goverse, Roel Hoekstra, Dirk Budding, Mathieu Pel, Richard GF Visser, Mirjam MJ Jacobs, Pavel Krenek, Ben Vosman   +33 more
core   +1 more source