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Candidate Genes for Insulin Resistance
Diabetes Care, 1996Insulin resistance confers increased susceptibility to NIDDM, atherosclerotic cardiovascular disease, ovarian hyperandrogenism, and possibly hypertension. Insulin resistance is largely inherited, in rare cases as a monogenic disorder or more commonly as a complex trait.
D E, Moller, C, Bjørbaek, A, Vidal-Puig
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ACTH Resistance: Genes and Mechanisms
2013ACTH resistance is a rare disorder typified by familial glucocorticoid deficiency (FGD), a genetically heterogeneous disease. Previously, genetic defects in FGD have been identified in the ACTH receptor gene (MC2R), its accessory protein (MRAP) and the steroidogenic acute regulatory protein gene (STAR).
E, Meimaridou +5 more
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Presse medicale (Paris, France : 1983), 1992
Among the different mechanisms of multidrug resistance, the overexpression of the mdr1 gene has been actively investigated during the last 5 years. This gene encodes a 170 kDa protein, named P-gp, a member of a transporter superfamily, the ABC (ATP Binding Cassette) proteins.
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Among the different mechanisms of multidrug resistance, the overexpression of the mdr1 gene has been actively investigated during the last 5 years. This gene encodes a 170 kDa protein, named P-gp, a member of a transporter superfamily, the ABC (ATP Binding Cassette) proteins.
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Gene Silencing-Based Disease Resistance
Transgenic Research, 2002The definition of a disease is fundamentally difficult, even if one considers only genetically based diseases. In its broadest sense, disease can be defined as any deviation from the norm that results in a physiological disadvantage. Natural selection ensures that the norm for any given species is constantly changing.
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Rinsho byori. The Japanese journal of clinical pathology, 2014
Genes encoding antibiotic-resistant factors may be exogenous or endogenous. Most exogenous genes originate from antibiotic-producing organisms. Bacteria can transfer antibiotic-resistant genes among themselves using gene-exchanging systems, such as plasmids, bacteriophages or integrative and conjugative elements.
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Genes encoding antibiotic-resistant factors may be exogenous or endogenous. Most exogenous genes originate from antibiotic-producing organisms. Bacteria can transfer antibiotic-resistant genes among themselves using gene-exchanging systems, such as plasmids, bacteriophages or integrative and conjugative elements.
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Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans
Nature Microbiology, 2019Tao He +27 more
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Continental-scale pollution of estuaries with antibiotic resistance genes
Nature Microbiology, 2017Yong-guan Zhu +9 more
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Resistance: gene deployment–durable resistance
Paul W. Bosland, Derek W. Barchengeropenaire +1 more source