Results 61 to 70 of about 1,162,589 (269)
Antibiotic-resistance and virulence-related genes in commercially bottled natural mineral waters
BMC MicrobiologyBackground To date, the presence of antibiotics resistant genes (ARGs) and virulence-related genes (VRGs) has been evidenced in several surface waters, including natural surface water and wastewater, as well as drinking water.
Giulia Radocchia +7 more
doaj +1 more source
Antibiotics, 2020 Antimicrobial resistance is on the rise in certain pathogens that infect pets and their owners. This has raised concerns about the use of antibiotics and the transfer of resistance elements in small animal clinics.
Veronika Zechner +3 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Virus resistance genes in plants
Uirusu, 2018 Plants defend themselves from virus infection by RNA silencing and resistance (R) gene-mediated mechanisms. Many dominant R genes encode nucleotide-binding site and leucine-rich repeat (NB-LRR)-containing proteins. NB-LRR proteins are also encoded by R genes against bacteria or fungi, suggesting a similar mechanism underlies defense systems to diverse ...
Kazuhiro, Ishibashi, Masayuki, Ishikawa
openaire +3 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Frontiers in MicrobiologyObjectiveTo analyze the molecular epidemiology and antimicrobial resistance profiles of carbapenem-resistant Klebsiella pneumoniae (CR-KP) isolates in Ningbo, with the aim of providing a theoretical basis for hospital infection control strategies and the
Hongfei Shi +11 more
doaj +1 more source
Infection and Drug Resistance, 2023 Fan Hu,1,2,* Meng-Lu Lin,1,2,* Juan-Li Mou,1,2,* Jia-Hui Feng,1,2 Kai Huang,1,2 Yao-Jia Lao,1,2 Jie Cheng,1,2 Jun Lin1,2 1Department of Gastroenterology/Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2The ...
Hu F +7 more
doaj
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source