Results 61 to 70 of about 1,259,159 (318)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gene amplification and insecticide resistance

Pest Management Science, 2011
AbstractPesticide resistance in arthropods has been shown to evolve by two main mechanisms, the enhanced production of metabolic enzymes, which bind to and/or detoxify the pesticide, and mutation of the target protein, which makes it less sensitive to the pesticide.
Bass, C., Field, L. M.
openaire   +2 more sources

ARDB--Antibiotic Resistance Genes Database [PDF]

Nucleic Acids Research, 2009
The treatment of infections is increasingly compromised by the ability of bacteria to develop resistance to antibiotics through mutations or through the acquisition of resistance genes. Antibiotic resistance genes also have the potential to be used for bio-terror purposes through genetically modified organisms. In order to facilitate the identification
Bo Liu 0021, Mihai Pop
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Virus resistance genes in plants

Uirusu, 2018
Plants defend themselves from virus infection by RNA silencing and resistance (R) gene-mediated mechanisms. Many dominant R genes encode nucleotide-binding site and leucine-rich repeat (NB-LRR)-containing proteins. NB-LRR proteins are also encoded by R genes against bacteria or fungi, suggesting a similar mechanism underlies defense systems to diverse ...
Kazuhiro, Ishibashi, Masayuki, Ishikawa
openaire   +3 more sources

Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene [PDF]

Antimicrobial Agents and Chemotherapy, 1994
Candida albicans is not inhibited by a number of drugs known to affect fungal cells. The basis for this resistance in most cases is unknown but has been attributed to the general impermeability of the fungal cell envelope. A gene (BENr) formerly shown to be responsible for the resistance of C.
R, Ben-Yaacov, S, Knoller, G A, Caldwell, J M, Becker, Y, Koltin   +4 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The L6 Gene for Flax Rust Resistance Is Related to the Arabidopsis Bacterial Resistance Gene RPS2 and the Tobacco Viral Resistance Gene N [PDF]

The Plant Cell, 1995
The L6 rust resistance gene from flax was cloned after tagging with the maize transposable element Activator. The gene is predicted to encode two products of 1294 and 705 amino acids that result from alternatively spliced transcripts. The longer product is similar to the products of two other plant disease resistance genes, the tobacco mosaic virus ...
G J, Lawrence, E J, Finnegan, M A, Ayliffe, J G, Ellis   +3 more
openaire   +2 more sources

Peroxidase profiling reveals genetic linkage between peroxidase gene clusters and basal host and non-host resistance to rusts and mildew in barley

, 2010
Background - Higher plants possess a large multigene family encoding secreted class III peroxidase (Prx) proteins. Peroxidases appear to be associated with plant disease resistance based on observations of induction during disease challenge and the ...
Stam, Piet, Linden, C. Gerard van der, Ana M. González, Stam Piet, Kohutova Zuzana, Thierry C Marcel, Marcel, T. C., Niks Rients E., Rients E Niks, Kohutova, Z., Ana M González, Zuzana Kohutova, Stam, P., González Fernández, Ana María, C Gerard van der Linden, Rients E. Niks, van der Linden, C.G., Marcel, T.C., van der Linden C. Gerard, C. Gerard van der Linden, Niks, R. E., Kohutova, Zuzana, Niks, R.E., González Ana M., Gonzalez, A.M., Piet Stam, Marcel Thierry C., Thierry C. Marcel, Linden, C.G., van der   +28 more
core   +1 more source

The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated. [PDF]

, 2012
BACKGROUND: Staphylococcus aureus is major human and animal pathogen. Plasmids often carry resistance genes and virulence genes that can disseminate through S. aureus populations by horizontal gene transfer (HGT) mechanisms. Sequences of S.
McCarthy, AJ, Lindsay Jodi A, Lindsay, JA, Jodi A Lindsay, McCarthy Alex J, Alex J McCarthy   +5 more
core   +1 more source