Results 81 to 90 of about 1,162,589 (269)

ZymoSoups: A High-Throughput Forward Genetics Method for Rapid Identification of Virulence Genes in Zymoseptoria tritici

Molecular Plant-Microbe Interactions
Septoria tritici blotch is caused by the fungus Zymoseptoria tritici and poses a major threat to wheat productivity. There are over 20 mapped loci in wheat that confer strong (gene-for-gene) resistance against this pathogen, but the corresponding genes ...
Haider Ali, Megan C. McDonald, Graeme J. Kettles   +2 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Multiplex Real-Time Polymerase Chain Reaction and Recombinase Polymerase Amplification: Methods for Quick and Cost-Effective Detection of Vancomycin-Resistant Enterococci (VRE)

Antibiotics
Background/Objectives: Vancomycin-resistant enterococci (VRE) are one of the leading causes of antibiotic-resistant infections in the hospital setting worldwide, and this has become a major issue, because most patients infected with this strain are ...
Ibukun Elizabeth Osadare, Abdinasir Abdilahi, Martin Reinicke, Celia Diezel, Maximilian Collatz, Annett Reissig, Stefan Monecke, Ralf Ehricht   +7 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Introducing Two Stripe Rust Resistance Genes, Yr5 and Yr15 to Some Iranian Bread Wheat Cultivars Using Marker-Assisted Backcrossing [PDF]

پژوهش‌های ژنتیک گیاهی
Stripe (yellow) rust, caused by Puccinia striiformis f. sp. tritici (Pst), is among the most important foliar diseases of wheat,posing a persistent threat to the production of such a strategic crop in many regions worldwide.
Fatemeh bagherzadeh, Hananeh Mirahmadi, Soraya Pourtabrizi, ali kazemi pour, Maryam Dorrani-Nejad, Roohollah Abdolshahi   +5 more
doaj  

PRGminer: harnessing deep learning for the prediction of resistance genes involved in plant defense mechanisms

Frontiers in Plant Science
Plant resistance genes are crucial in plant defense systems against a variety of diseases and pests. These plant-specific genes encode proteins that identify particular molecular patterns associated with pathogens invading the plants.
Naveen Duhan, Naveen Duhan, Rakesh Kaundal, Rakesh Kaundal   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transcriptomics and metabolomics analyses provide insights into resistance genes of tree ferns

Frontiers in Genetics
As ancient organisms, tree ferns play a crucial role as an evolutionary bridge between lower and higher plant species, providing various utilitarian benefits.
Weicheng Yang, Qinqin He, Lijun Zhang, Jiaxing Xiao, Jiao Yang, Bingjie Che, BingChen Zhang, Handan Chen, Jiang Li, Yu Jiang   +9 more
doaj   +1 more source