Results 131 to 140 of about 810,262 (267)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multidrug antibiotic resistance index and antimicrobial resistance patterns of Escherichia coli in intensive pig farms in Kenya. [PDF]

One Health Outlook
Inguyesi C, Olum M, Ndirangu P, Langat N, Jesang A, Masila E, Wachuka E, Onywera R, Muloi D, Ochieng L, Yamo V, Momanyi K, Muinde P, Maichomo M.   +13 more
europepmc   +1 more source

Drought resistance index screening and evaluation of lettuce under water deficit conditions on the basis of morphological and physiological differences. [PDF]

Front Plant Sci, 2023
Li J, Abbas K, Wang L, Gong B, Hou S, Wang W, Dai B, Xia H, Wu X, Lü G, Gao H.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparison of novel nutritional index (TCBI) and insulin resistance index (TyG-BMI) for assessing cardiovascular disease risk: a cohort study. [PDF]

J Health Popul Nutr
Wang Y, Mo D, Hu W, Zhong Y, Li Z, Ma H, Jiang N, Wang T, Yu X.   +8 more
europepmc   +1 more source

Mitral valve systemic vascular resistance index in cardiac surgery should be one more enigma. [PDF]

J Thorac Dis, 2023
Evora PRB.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Performance of a Novel Computational Hyperemic Resistance Index Derived from Cardiac CT in Coronary Chronic Syndromes. [PDF]

J Clin Med
Bellouche Y, Benic C, Hannachi S, Nicol PP, Jousse C, Le Ven F, Mansourati J, Pasdeloup B, Didier R.   +8 more
europepmc   +1 more source

Lipoprotein Insulin Resistance Index: A Simple, Accurate Method for Assessing Insulin Resistance in South Asians. [PDF]

J Endocr Soc, 2023
Fosam A, Bansal R, Ramanathan A, Sarcone C, Iyer I, Murthy M, Remaley AT, Muniyappa R.   +7 more
europepmc   +1 more source

Delta resistive index

, 2016
Jeremy Jones, Craig Hacking, Matt Morgan
openaire   +1 more source