Results 141 to 150 of about 1,444,587 (217)

Unraveling the Role of P450 Reductase in Herbicide Metabolic Resistance Mechanism. [PDF]

Plant Direct
Rigon CAG, Iwakami S, Gaines TA, Dayan FE.   +3 more
europepmc   +1 more source

Editorial: Antibody-based novel target immunotherapy in hematological malignancy

Frontiers in Oncology
Weijie Cao, Yingmei Li, Haizhou Xing, Zhongxing Jiang, Jifeng Yu   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A metabolite-based resistance mechanism against malaria. [PDF]

Science
Figueiredo A, Rastogi ST, Ramos S, Nogueira F, De Villiers K, de Sousa AGG, Votborg-Novél L, von Wedel C, Tober-Lau P, Jentho E, Pagnotta S, Mesquita M, Cardoso S, Bortolussi G, Muro AF, Tranfield EM, Thibaud J, Duarte D, Sousa AL, Sousa AL, Pinto SN, Kitoko J, Mombo-Ngoma G, Mischlinger J, Junttila S, Alenquer M, Amorim MJ, Vasavda C, Bosma PJ, Violante S, Drotleff B, Paixão T, Portugal S, Kurth F, Elo LL, Paul BD, Martins R, Soares MP.   +37 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Acquired <i>ROS1</i> Intragenic Rearrangements as a Resistance Mechanism in <i>EGFR</i>-Mutant Non-Small Cell Lung Cancer: A Case Series. [PDF]

Curr Oncol
Liu PT, Chen YL, Chen WL, Ho CL, Lee CH.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Acquisition of amantadine resistance via M gene reassortment in canine H3N2 influenza virus and elucidation of the resistance mechanism. [PDF]

Virol J
Ga E, Bae E, Xie X, Hwang J, Yeom M, Lim JW, Song D, Na W.   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Overcoming the sorafenib resistance mechanism in FLT3-mutated acute myeloid leukemia: molecular basis and new targets. [PDF]

Front Oncol
Peng H, Li M, Peng YY, Li XL, Yang J, Sun QG, Song K.   +6 more
europepmc   +1 more source