In vitro susceptibility of common Enterobacterales to eravacycline in Taiwan
Journal of Microbiology, Immunology and Infection, 2023 Background: New tetracycline derivatives exhibit broad-spectrum antimicrobial activities. This study aimed to assess the in vitro activity of eravacycline against common Enterobacterales. Methods: Clinical Enterobacterales isolates were collected between
Jann-Tay Wang +2 more
exaly +4 more sources
Efficacy and safety of eravacycline: A meta-analysis
Journal of Global Antimicrobial Resistance, 2021 Objectives: This study was conducted to evaluate the efficacy and safety of eravacycline, a recently approved fluorocycline for treatment of complicated intra-abdominal infections (cIAIs).
Khalid Eljaaly +2 more
exaly +4 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objectives: This study aimed to investigate the synergistic activity of eravacycline combined with other antimicrobial agents against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii collected from China.
Lanqing Cui
exaly +3 more sources
Eravacycline monotherapy and combination therapy against KPC-2- and NDM-1-co- producing Klebsiella pneumoniae: in vitro and in vivo activity analysis [PDF]
Frontiers in MicrobiologyBackgroundThe emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) co-producing KPC-2 and NDM-1 (K2N1-CRKP) has intensified a major public health threat and severely limited therapeutic options.
Xiaojie Zhao +18 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Eravacycline is a novel, fully-synthetic tetracycline approved by the FDA for treatment of complicated intra-abdominal infections in August 2018.
Athena L V Hobbs +2 more
exaly +3 more sources
Clinical experience with eravacycline-based combination therapy for carbapenem-resistant Acinetobacter baumannii pneumonia: a prospective observational case series [PDF]
Frontiers in PharmacologyObjectiveThis study was conducted to investigate the clinical response, safety, and pharmacokinetic (PK) profile of eravacycline-based combination therapies in patients with pulmonary infections caused by carbapenem-resistant Acinetobacter baumannii ...
Ying Xiao +9 more
doaj +2 more sources
Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation [PDF]
Annals of Clinical Microbiology and AntimicrobialsPurpose This study evaluated the impact of sub-MIC eravacycline exposure on carbapenem-resistant Acinetobacter baumannii with tigecycline MIC ≥ 8 µg/mL in clinical laboratory testing, and analyzed the resistance mechanisms. Methods 2144 A.
Xu Yang +6 more
doaj +2 more sources
The Efficacy and Safety of Eravacycline in the Management of Infections: A Single-Center Experience [PDF]
AntibioticsBackground/Objectives: Eravacycline is a fluorocycline antibiotic increasingly used for drug-resistant or difficult-to-treat infections, including off-label indications, with limited real-world clinical data.
Narendran Koomanan +2 more
doaj +2 more sources
Incidence and characteristics of eravacycline-associated increase in serum bilirubin levels: a retrospective study [PDF]
Frontiers in PharmacologyObjectivesTo compare the effects of eravacycline and tigecycline on serum bilirubin levels and investigate the incidence and clinical characteristics of total bilirubin increase associated with eravacycline.MethodsWe conducted a retrospective study in ...
Yueyue Si +9 more
doaj +2 more sources
Coagulation dysfunction events associated with novel tetracycline-class drugs: a disproportionality and Bayesian analysis based on the FAERS database [PDF]
Frontiers in AntibioticsIntroductionIn contemporary clinical practice, novel tetracycline-class antimicrobial agents have been increasingly utilized due to their favorable pharmacological profiles.
Hongxin Li +5 more
doaj +2 more sources