In vitro susceptibility of common Enterobacterales to eravacycline in Taiwan
Journal of Microbiology, Immunology and Infection, 2023 Background: New tetracycline derivatives exhibit broad-spectrum antimicrobial activities. This study aimed to assess the in vitro activity of eravacycline against common Enterobacterales. Methods: Clinical Enterobacterales isolates were collected between
Jann-Tay Wang
exaly +5 more sources
Eravacycline monotherapy and combination therapy against KPC-2- and NDM-1-co- producing Klebsiella pneumoniae: in vitro and in vivo activity analysis [PDF]
Frontiers in MicrobiologyBackgroundThe emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) co-producing KPC-2 and NDM-1 (K2N1-CRKP) has intensified a major public health threat and severely limited therapeutic options.
Xiaojie Zhao +18 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objectives: This study aimed to investigate the synergistic activity of eravacycline combined with other antimicrobial agents against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii collected from China.
Lanqing Cui
exaly +3 more sources
Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation [PDF]
Annals of Clinical Microbiology and AntimicrobialsPurpose This study evaluated the impact of sub-MIC eravacycline exposure on carbapenem-resistant Acinetobacter baumannii with tigecycline MIC ≥ 8 µg/mL in clinical laboratory testing, and analyzed the resistance mechanisms. Methods 2144 A.
Xu Yang +6 more
doaj +2 more sources
Microbiology Spectrum, 2022 The evolution of bacterial antibiotic resistance is exhausting the list of currently used antibiotics and endangers those in the pipeline. The combination of antibiotics is a promising strategy that may suppress resistance development and/or achieve ...
Yongxin Jin, Fang Bai, Shuiping Chen
exaly +3 more sources
Incidence and characteristics of eravacycline-associated increase in serum bilirubin levels: a retrospective study [PDF]
Frontiers in PharmacologyObjectivesTo compare the effects of eravacycline and tigecycline on serum bilirubin levels and investigate the incidence and clinical characteristics of total bilirubin increase associated with eravacycline.MethodsWe conducted a retrospective study in ...
Yueyue Si +9 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Eravacycline is a novel, fully-synthetic tetracycline approved by the FDA for treatment of complicated intra-abdominal infections in August 2018.
Athena L V Hobbs +2 more
exaly +3 more sources
Development and Validation of a Rapid LC-MS/MS Method for Quantifying Eravacycline in Epithelial Lining Fluid: Application to a Prospective Pulmonary Distribution Study in HAP/VAP Patients [PDF]
AntibioticsBackground: Eravacycline exhibits potent activity against multidrug-resistant pathogens and holds promise for the management of hospital-acquired and ventilator-associated pneumonia (HAP/VAP).
Jingjing He +8 more
doaj +2 more sources
Assessment of Eravacycline Antimicrobial Susceptibility in China During the First Year Following Regulatory Approval (2023–2024): A Real-World Study [PDF]
MicroorganismsEravacycline, a novel fluorocycline antimicrobial, was approved by China’s National Medical Products Administration (NMPA) in March 2023; however, clinical breakpoints and real-world data on its use in China remain limited.
Qiaolian Yi +5 more
doaj +2 more sources
Eravacycline pharmacokinetics/pharmacodynamics in the hollow fiber system model of Mycobacterium abscessus lung disease [PDF]
Microbiology SpectrumTreatment of Mycobacterium abscessus (MAB) pulmonary diseases is challenging due to intrinsic resistance to many antibiotics and requires prolonged intravenous therapy with drugs that have severe side effects.
Sanjay Singh +6 more
doaj +2 more sources