Results 1 to 10 of about 1,785 (194)

Efficacies of omadacycline + amikacin + imipenem and an all-oral regimen omadacycline + clofazimine + linezolid in a mouse model of M. abscessus lung disease

mSphere
Treatment outcomes for Mycobacteroides abscessus (Mab, also known as Mycobacterium abscessus) disease are still unsatisfactory, mainly due to issues with drug toxicity, tolerability, and efficacy.
Elisa H. Ignatius, Binayak Rimal, Chandra M. Panthi, Daniel C. Belz, Christopher K. Lippincott, Daniel H. Deck, Alisa W. Serio, Gyanu Lamichhane   +7 more
doaj   +2 more sources

Possible omadacycline induce acute pancreatitis: a case report and literature review

BMC Infectious Diseases
Background Omadacycline is a new generation of tetracycline antibiotics, and its clinical application is increasing. We report the first case of acute pancreatitis possibly induced by omadacycline.
Qiang Xu, Yanlei Sang, Huanran Zhang, Qingwei Zhao   +3 more
doaj   +2 more sources

Empiric treatment approach for the management of post-operative incisional infections with omadacycline

Foot & Ankle Surgery: Techniques, Reports & Cases, 2023
: Background: Surgical wound dehiscence (SWD) is one of the most common complications of surgical incision sites after foot surgeries because of blood flow and circulation issues that may occur in the foot. Such SWD complications can potentially lead to
Philip Wrotslavsky
doaj   +2 more sources

Case Report: Omadacycline in the treatment of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in an adolescent patient [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Omadacycline is a novel tetracycline antibiotic that exhibits good in vitro antibacterial activity against atypical pathogens such as Mycoplasma pneumoniae. It is approved for the treatment of adults with community-acquired bacterial pneumonia.
Limin Xu, Changquan Fang
doaj   +2 more sources

Omadacycline for the treatment of patients with Legionella pneumophila pneumonia after experiencing liver dysfunction: case series

Frontiers in Microbiology
IntroductionAntibiotics frequently induce abnormal liver function. Omadacycline is a novel aminomethylcycline antibiotic, which shows potent activity against Gram-positive and Gram-negative aerobic, anaerobic, and atypical (including Legionella ...
Ani Zhu, Qian Ma, Zhiyan Liu
doaj   +1 more source

Omadacycline for the treatment of acute bacterial skin and skin structure infections: a systematic review and network meta-analysis

BMC Infectious Diseases
Background Few studies have compared the efficacy and safety of omadacycline with other treatments for acute bacterial skin and skin structure infections (ABSSSI). Therefore, updated meta-analyses on this topic is necessary.
Wen-qiang Kong, Yun-feng Shu , Juan Tang, Shi-qin Li, Hong Zhong, Xuan-yi Zhang   +5 more
doaj   +1 more source

In vitro activity and in vivo efficacy of omadacycline against Plasmodium species

Malaria Journal
Background Doxycycline is currently the only tetracycline-class antibiotic recommended for malaria prophylaxis. Omadacycline, a semisynthetic aminomethylcycline approved for treatment of adults with community-acquired bacterial pneumonia and acute ...
Michael S. Madejczyk, Susan E. Leed, Karl Kudyba, Alison Roth, Monica L. Martin, Patricia Lee, Diane Anastasiou, Jessica V. Pierce, Alisa W. Serio, Diana Caridha   +9 more
doaj   +1 more source

A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii

Frontiers in Microbiology
BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAB)-caused severe pneumonia is associated with high mortality rates, and treatment options are limited.
Dayu Chen, Yechao Chen, Yechao Chen, Na Hu, Qiaoling Gu, Qiaoling Gu, Jingjing Kan, Jingjing Kan, Jinchun Liu, Haixia Zhang   +9 more
doaj   +1 more source

Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system

Acta Pharmaceutica
This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between the second ...
Wang Zhu, Gan Guoping, Yao Haiping
doaj   +1 more source

Immunomodulatory activity of omadacycline in vitro and in a murine model of acute lung injury

mSphere
Cystic fibrosis (CF) is characterized by chronic airway obstruction, infection, and inflammation leading to progressive loss of lung function and eventual respiratory failure.
Madeline Sanders, Paul Beringer
doaj   +1 more source