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Amikacin: Uses, Resistance, and Prospects for Inhibition
Molecules, 2017 Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad spectrum of bacterial infections. The primary resistance mechanism against these antibiotics is enzymatic modification by aminoglycoside-modifying enzymes that are
Maria Soledad Ramirez +2 more
exaly +4 more sources
The Direction of the Antibacterial Effect of Rutin Hydrate and Amikacin
Antibiotics, 2023 The aim of the presented study was to examine the in vitro antimicrobial activity of rutin hydrate (RH) alone and in combination with amikacin against 12 reference strains of Gram-positive and Gram-negative bacteria.
Maria Miklasińska-Majdanik +5 more
doaj +2 more sources
Heteroresistance to Amikacin in Carbapenem-Resistant Klebsiella pneumoniae Strains
Frontiers in Microbiology, 2021 Heteroresistance can lead to treatment failure and is difficult to detect by the methods currently employed by clinical laboratories. The aim of this study was to investigate the prevalence of the amikacin-heteroresistant Klebsiella pneumoniae strains ...
Feiyang Zhang +7 more
doaj +2 more sources
Antimicrobial Agents and Chemotherapy, 2019 In the present study, we employed untargeted metabolomics to investigate the synergistic killing mechanism of polymyxin B in combination with an aminoglycoside, amikacin, against a polymyxin-susceptible isolate of Pseudomonas aeruginosa, FADDI-PA111 (MIC
Maytham Hussein, Mei-Ling Han, Yan Zhu
exaly +2 more sources
Predatory Bacteria: A Potential Ally against Multidrug-Resistant Gram-Negative Pathogens [PDF]
, 2013 Multidrug-resistant (MDR) Gram-negative bacteria have emerged as a serious threat to human and animal health. Bdellovibrio spp. and Micavibrio spp. are Gram-negative bacteria that prey on other Gram-negative bacteria.
A Dashiff +26 more
core +13 more sources
Microbiology Spectrum, 2021 Ceftazidime-avibactam (CZA) has emerged as a promising solution to the lack of new antibiotics against Pseudomonas aeruginosa infections. Data from in vitro assays of CZA combinations, however, are scarce. The objective of our study was to perform a time-
María M. Montero +12 more
doaj +1 more source
Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
Nature Communications, 2023 Aminoglycosides are a class of antibiotics that bind to ribosomal RNA and exert pleiotropic effects on ribosome function. Amikacin, the semisynthetic derivative of kanamycin, is commonly used for treating severe infections with multidrug-resistant ...
semanticscholar +1 more source
Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin
Molecules, 2022 Three porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid.
Marta Glinka +7 more
doaj +1 more source
Cochrane Database of Systematic Reviews, 2021 Background The World Health Organization (WHO) End TB Strategy stresses universal access to drug susceptibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs.
S. Pillay +7 more
semanticscholar +1 more source
Glucose-Potentiated Amikacin Killing of Cefoperazone/Sulbactam Resistant Pseudomonas aeruginosa
Frontiers in Microbiology, 2022 Multidrug-resistant Pseudomonas aeruginosa has become one of global threat pathogens for human health due to insensitivity to antibiotics. Recently developed reprogramming metabolomics can identify biomarkers, and then, the biomarkers were used to revert
Xi-kang Tang +13 more
doaj +1 more source