Results 21 to 30 of about 162,947 (233)

Stability and antimicrobial effect of amikacin-loaded solid lipid nanoparticles [PDF]

, 2010
Solmaz Ghaffari1, Jaleh Varshosaz1, Afrooz Saadat2, Fatemeh Atyabi21Department of Pharmaceutics, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; 2Department of Pharmaceutics,
Afrooz Saadat, et al, Jaleh Varshosaz, Solmaz Ghaffari   +3 more
core   +1 more source

Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos [PDF]

, 2012
We used zebrafish as a model to assess amikacin-induced embryotoxicity. We exposed zebrafish embryos to amikacin, using different amikacin doses (0-10 ppm), durations (12-48 h), and onsets (0, 24, 48 hpf).
Chen, Y.H.; Tsai, I.T.; Wen, C.C.; Wang, Y.H.; Cheng, C.C.; Hu, S.C0; Chen, Y.H., Chen, Ying-Hsin; Tsai, I-Ting; Wen, Chi-Chung; Wang, Yun-Hsin; Cheng, Chien-Chung; Hu, Sheng-Chuan; Chen, Yau-Hung, Chen, Yau-Hung   +2 more
core   +1 more source

Impact of the Epithelial Lining Fluid Milieu on Amikacin Pharmacodynamics Against Pseudomonas aeruginosa

, 2021
Background: Even though nebulised administration of amikacin can achieve high epithelial lining fluid concentrations, this has not translated into improved patient outcomes in clinical trials.
Heffernan, AJ, Andrews, KT, Lim, SMS, Grimwood, K, Roberts, JA, Naicker, S, Sime, FB, Ellwood, D, Lipman, J   +8 more
core   +1 more source

Late-Onset Meningitis due to <i>Serratia marcescens</i> in a Preterm Infant: A Rare Sporadic Case Report From a Cambodian NICU. [PDF]

Clin Case Rep
ABSTRACT Late‐onset neonatal meningitis due to Serratia marcescens is an uncommon but potentially life‐threatening healthcare‐associated infection in NICUs. We report a sporadic case in a preterm infant who developed fever on Day 17 of life after a prolonged hospital stay for feeding difficulties and neonatal jaundice.
Seng B, Im S, Bin S.
europepmc   +2 more sources

Amikacin-induced Fin Reduction is Mediated by Autophagy [PDF]

, 2013
Despite its medical use, little is known about the mechanisms underlying amikacin-induced embryotoxicity, including fin reduction, in zebrafish. In this study, we examined the expression of well-known autophagy markers mTOR (target of rapamycin), atg10 ...
Tsai, I-Ting; Chen, Yau-Hung; Wang, Yun-Hsin, Chen, Yau-Hung; Wang, Yun-Hsin   +1 more
core   +1 more source

Comparison of Treatment Outcomes of Cavitary Mycobacterium avium Complex Pulmonary Disease with Streptomycin or Amikacin Use

Microbiology Spectrum, 2023
The comparative outcomes of specific aminoglycosides in cavitary type (fibrocavitary or cavitary nodular bronchiectatic type) Mycobacterium avium complex (MAC) pulmonary disease (PD) are unelucidated.
Seong Min Kim, Yong Pil Chong, Hyun Joo Lee, Tae Sun Shim, Kyung-Wook Jo   +4 more
doaj   +1 more source

Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa

, 2021
This study aims to compare the bacterial killing of once- versus twice-daily nebulized amikacin against Pseudomonas aeruginosa and to determine the optimal duration of therapy. Three clinical P.
Heffernan, AJ, Guerra-Valero, Y, Andrews, K, Grimwood, K, Wallis, S, Roberts, JA, Naicker, S, Sime, FB, Ellwood, D, Lipman, J   +9 more
core   +1 more source

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and bla_NDM-5: Preparation for a Postantibiotic Era

mBio, 2017
The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as ...
Zackery P. Bulman, Liang Chen, Thomas J. Walsh, Michael J. Satlin, Yuli Qian, Jürgen B. Bulitta, Charles A. Peloquin, Patricia N. Holden, Roger L. Nation, Jian Li, Barry N. Kreiswirth, Brian T. Tsuji   +11 more
doaj   +1 more source

Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates

Microbiology Spectrum, 2021
Ceftazidime-avibactam (CZA) has emerged as a promising solution to the lack of new antibiotics against Pseudomonas aeruginosa infections. Data from in vitro assays of CZA combinations, however, are scarce. The objective of our study was to perform a time-
María M. Montero, Sandra Domene Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Inmaculada López Montesinos, Eduardo Padilla, Núria Prim, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

Carvacrol attenuates amikacin-induced nephrotoxicity in the rats

Recent Trends in Pharmacology
Objective: Amikacin (AK) is a wide-spectrum antibiotic routinely used to treat gram-negative and some gram-positive bacterial infections. However, its use is limited due to its potential to cause nephrotoxicity due to an increase in reactive oxygen ...
Cemil Çolak, Ahmet Sefa Duman, Yılmaz Çiğremiş, Atta Mohammad Dost, Selahattin Tunç, Nigar Vardı, Azibe Yıldız, Onural Özhan, Hakan Parlakpınar, Mehmet Günata   +9 more
doaj   +1 more source