Results 11 to 20 of about 1,785 (194)

Case Report: Omadacycline in the Treatment of Community‐Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies [PDF]

Clinical Case Reports
Omadacycline, a novel once‐daily aminomethylcycline antibiotic agent, demonstrates efficacy against prevalent pathogens responsible for community‐acquired pneumonia (CAP) in adults.
Ziqi Xu, Wen Pan, Hui Lei, Chen Dong, Biao Zou, Sainan Shu, Wenting Zhang   +6 more
doaj   +3 more sources

Efficacy of drug regimens containing omadacycline in a murine model of Mycobacterium avium chronic lung infection [PDF]

Frontiers in Microbiology
Mycobacterium avium complex (MAC) is the most common non-tuberculous mycobacteria (NTM) and most frequent causative pathogen of NTM pulmonary infections. MAC is often associated with comorbidities, chronic infections, and high mortality rates.
Jean-Philippe Lanoix, Jean-Philippe Lanoix, Antoine Froment, Antoine Froment, Julia Delomez, Julia Delomez, Jessica V. Pierce, Alisa W. Serio, Morgane Choquet, Marie Perret, François Peltier, Cédric Joseph, Denis Chatelain, Claire Andréjak, Claire Andréjak   +14 more
doaj   +3 more sources

Efficacy and safety of Omadacycline in community-acquired pneumonia among elderly patients: a real-world evidence study [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aimed to evaluate real-world effectiveness and safety of omadacycline for elderly community-acquired pneumonia (CAP) versus tigecycline, moxifloxacin, and cefoperazone-sulbactam after inverse probability of treatment weighting (IPTW ...
Xinran Xie, Xinran Xie, Jiayu Deng, Gengyuan Sun, Yanqing Song, Yanqing Song   +5 more
doaj   +3 more sources

Efficacy of omadacycline in the treatment of Legionella pneumonia: a case report [PDF]

Frontiers in Cellular and Infection Microbiology
Legionella, one of the main pathogens that causes community-acquired pneumonia, can lead to Legionella pneumonia, a condition characterized predominantly by severe pneumonia.
Qiang Qu, Jian Qu
exaly   +4 more sources

Efficacy and short-term safety of intravenous omadacycline as second-line therapy for macrolide- unresponsive Mycoplasma pneumoniae pneumonia in children: a retrospective cohort study [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveTo evaluate the efficacy and short-term safety of omadacycline as second-line therapy for macrolide-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) in children aged 8–16 years.MethodsA total of 64 hospitalized children with MUMPP admitted ...
Yang Yu, Tingting Zhang, Yu Xia, Yao Sun
doaj   +3 more sources

In Vitro Activity of Omadacycline and Comparator Antibiotics against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Urinary Isolates

Antibiotics, 2023
Limited oral antibiotic options exist for urinary tract infections (UTI) caused by ESBL-producing Enterobacterales. The aim of the study was to evaluate in vitro activity of omadacycline and comparator antibiotics against clinical ESBL-producing and non ...
Tyler J. Stone, Abdullah Kilic, John C. Williamson, Elizabeth L. Palavecino   +3 more
doaj   +2 more sources

Evaluating the Efficacy of Eravacycline and Omadacycline against Extensively Drug-Resistant Acinetobacter baumannii Patient Isolates

Antibiotics, 2022
For decades, the spread of multidrug-resistant (MDR) Acinetobacter baumannii has been rampant in critically ill, hospitalized patients. Traditional antibiotic therapies against this pathogen have been failing, leading to rising concerns over management ...
Manas S. Deolankar, Rachel A. Carr, Rebecca Fliorent, Sean Roh, Henry Fraimow, Valerie J. Carabetta   +5 more
doaj   +2 more sources

Omadacycline: A New Tetracycline Antibiotic

Annals of Pharmacotherapy, 2018
Objective: To review the chemistry, pharmacology, microbiology, pharmacokinetics, pharmacodynamics, clinical efficacy, tolerability, dosage, and administration of omadacycline, a new tetracycline antibiotic. Data Sources: A literature search through PubMed, Google Scholar, and clinicaltrials.gov was conducted (2008 to October 2018) using the search ...
Dougherty, John A., Sucher, Allana J., Chahine, Elias B., Shihadeh, Katherine C.   +3 more
openaire   +3 more sources

Omadacycline versus moxifloxacin for community-acquired bacterial pneumonia (OPTIC-2): a phase 3b, randomised, double-blind, multicentre, controlled, noninferiority trialResearch in context [PDF]

EClinicalMedicine
Summary: Background: Omadacycline is a first-in-class aminomethylcycline antibiotic approved to treat adults with community-acquired bacterial pneumonia (CABP).
Thomas M. File, Jr., Keith S. Kaye, Skliarov Ihor, Iryna Hovbakh, Vakhtang Katsarava, Courtney Kirsch, Karan Soni, Kushagra Gupta, Amy Manley, Daniel H. Deck, Diane Anastasiou, Surya Chitra, Stephen Villano   +12 more
doaj   +2 more sources

In vitro and in vivo activity of omadacycline against Mycobacterium tuberculosis [PDF]

Frontiers in Microbiology
The bedaquiline (B), pretomanid (Pa), and linezolid (L) (BPaL) regimen is highly effective for drug-resistant tuberculosis (TB) but is limited by linezolid-associated toxicities, including myelosuppression and peripheral neuropathy.
Shahebraj Khan, Duc Nguyen, Dejan Nikolic, Baojie Wan, Akil Hossain, Mallique Qader, Sanghyun Cho, Scott G. Franzblau, Gauri S. Shetye   +8 more
doaj   +2 more sources