Results 41 to 50 of about 1,785 (194)

Antimicrobial activity of omadacycline in vitro against bacteria isolated from 2014 to 2017 in China, a multi-center study

BMC Microbiology, 2020
Background Omadacycline (ZL-2401) is a semi-synthetic derivative of minocycline. It has a broadspectrum activity against Gram-positive and Gram-negative bacteria, and atypical pathogens.
Meng Xiao, Jing-jing Huang, Ge Zhang, Wen-hang Yang, Fanrong Kong, Timothy Kudinha, Ying-chun Xu   +6 more
doaj   +1 more source

Preliminary, real-world, multicenter experience with omadacycline for Mycobacterium abscessus infections [PDF]

, 2021
Twelve patients were treated with omadacycline (OMC) as part of a multidrug regimen ...
Veve, Michael P., Bouchard, Jeannette, Webb, Andrew J., Philley, Julie V, Veve, Michael P, Alosaimy, Sara, Cohen, Keira A, Morrisette, Taylor, Gore, Tristan W, Rybak, Michael J., Rybak, Michael J, Gore, Tristan W., Wadle, Carly, Ansari, Iman, Mejia-Chew, Carlos, Lagnf., Abdalhamid M., Philley, Julie V., Cohen, Keira A., Barger, Melissa L, Howard, Catessa, Webb, Andrew J, Barger, Melissa L., Lagnf, Abdalhamid M   +22 more
core   +3 more sources

Omadacycline in the treatment of community-acquired bacterial pneumonia in patients with comorbidities: a post-hoc analysis of the phase 3 OPTIC trial

Frontiers in Medicine, 2023
IntroductionThe 2019 American Thoracic Society/Infectious Disease Society of America guidelines recommend respiratory fluoroquinolones to treat community-acquired bacterial pneumonia (CABP) in adults with comorbidities.
George D. Rodriguez, George D. Rodriguez, Nathan Warren, Roman Yashayev, Surya Chitra, Maria Amodio-Groton, Kelly Wright   +6 more
doaj   +1 more source

Microbiology and Preclinical Review of Omadacycline [PDF]

Clinical Infectious Diseases, 2019
AbstractOmadacycline is a novel aminomethylcycline antimicrobial and semisynthetic derivative of tetracycline. In vitro, omadacycline displays potent activity against gram-positive and many gram-negative bacteria, including methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, β-hemolytic streptococci, vancomycin-resistant Enterococcus,
Karlowsky, James A, Steenbergen, Judith, Zhanel, George G   +2 more
openaire   +2 more sources

In vitro activity of omadacycline, a new tetracycline analog, and comparators against Clostridioides difficile. [PDF]

, 2020
Omadacycline is a potent aminomethylcycline with in vitro activity against Gram-positive, Gram-negative, and anaerobic bacteria. Preliminary data demonstrated that omadacycline has in vitro activity against Clostridioides difficile; however, large-scale ...
Miranda, Julie, Carlson, Travis J, Gonzales-Luna, Anne J, Garey, Kevin W, Wilcox, Mark H, Bassères, Eugénie, Alam, M Jahangir, Rashid, Tasnuva, Lancaster, Chris, Begum, Khurshida, Eyre, David W   +10 more
core   +1 more source

Efficacy of Omadacycline-Containing Regimen in a Mouse Model of Pulmonary Mycobacteroides abscessus Disease

mSphere, 2023
Mycobacteroides abscessus is an opportunistic pathogen in people with structural lung conditions such as bronchiectasis, chronic obstructive pulmonary disease, and cystic fibrosis. Pulmonary M.
Binayak Rimal, Danielle A. Nicklas, Chandra M. Panthi, Christopher K. Lippincott, Daniel C. Belz, Elisa H. Ignatius, Daniel H. Deck, Alisa W. Serio, Gyanu Lamichhane   +8 more
doaj   +1 more source

Omadacycline [PDF]

Hospital Pharmacy, 2019
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing ...
openaire   +2 more sources

Prepared omadacycline for injection: Nine-day stability and sterility in an elastomeric pump

SAGE Open Medicine, 2022
Objective: To investigate compatibility, stability, and microbiologic risk of omadacycline 1 mg/mL when prepared in an elastomeric infusion pump and stored under refrigeration for 9 days based upon requests for information from healthcare providers ...
Jason Bower, Kelly Wright, Jason Burdette   +2 more
doaj   +1 more source

Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility

Microbiology Spectrum, 2022
Tetracycline-based combinations are increasingly used for serious carbapenem-nonsusceptible Acinetobacter baumannii (CNSAb) infections given their potent in vitro activity, synergism with other agents, and acceptable toxicity profile.
Taylor Abbey, Alesia Vialichka, Michele Jurkovic, Mark Biagi, Eric Wenzler   +4 more
doaj   +1 more source

Omadacycline as a drug candidate for Mycobacterium avium infections: in vitro insights on single and combination therapies. [PDF]

J Antimicrob Chemother
Objectives: The current antibiotic arsenal for the treatment of Mycobacterium avium infections is limited and new treatment options are needed. This exploratory study assessed the in vitro activity of omadacycline against M. avium alone and combined with
Mudde SE, Meliefste HM, Klaassen CHW, Ammerman NC, Pierce JV, Serio AW, De Steenwinkel JEM, Bax HI.   +7 more
europepmc   +2 more sources