Results 41 to 50 of about 1,472 (172)

Pathogens susceptible to tetracycline are also susceptible to omadacycline: tetracycline as a one-sided surrogate to predict omadacycline susceptible pathogens

Diagnostic Microbiology and Infectious Disease, 2022
This study used surveillance data from a global program of clinical bacterial isolates to determine whether a tetracycline susceptible result can be used to predict an omadacycline susceptible result. Categorical agreement, very major error rates, and minor error rates were calculated for Staphylococcus aureus (MSSA and MRSA; n=38,364), S. lugdunensis (
Alisa W. Serio, Tiffany R. Keepers, Kelly Wright, Diane Anastasiou   +3 more
openaire   +2 more sources

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Omadacycline for Community-Acquired Bacterial Pneumonia

New England Journal of Medicine, 2019
Omadacycline, a new once-daily aminomethylcycline antibiotic agent that can be administered intravenously or orally, reaches high concentrations in pulmonary tissues and is active against common pathogens that cause community-acquired bacterial pneumonia.In a double-blind trial, we randomly assigned (in a 1:1 ratio) adults with community-acquired ...
Roman, Stets, Monica, Popescu, Joven R, Gonong, Ismail, Mitha, William, Nseir, Andrzej, Madej, Courtney, Kirsch, Anita F, Das, Lynne, Garrity-Ryan, Judith N, Steenbergen, Amy, Manley, Paul B, Eckburg, Evan, Tzanis, Paul C, McGovern, Evan, Loh   +14 more
openaire   +2 more sources

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

A Case Report of a Multisystemic Immune‐Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha‐1

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT To report a case of a nasopharyngeal carcinoma patient who developed multisystem immune‐related adverse events (irAEs) after treatment with sintilimab (PD‐1 inhibitor) in combination with thymosin alpha‐1 (Tα1). The patient presents with high fever, rash, interstitial pulmonary edema, and multiple organ failure.
Ting Li, Bao‐Liang Wu, Cai‐Long Yu, Liang‐Yan Jin   +3 more
wiley   +1 more source

Early Clinical Response of a Large Amebic Liver Abscess to Eravacycline Prior to Metronidazole Initiation: A Case Report

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Entamoeba histolytica is an amebic protozoan that is often asymptomatic, with many patients being asymptomatic carriers. However, 10 percent of cases manifest with amebic dysentery and, less commonly, amebic liver abscesses. Amebic liver abscesses are the most common extraintestinal manifestation of E. histolytica.
Jamal A. Anthony, Andrew Robinson, Lisa Pedroza, Rajib Chowdhury   +3 more
wiley   +1 more source

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of ¹⁴ C-Omadacycline in Rats [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT The absorption, distribution, metabolism, and excretion (ADME) of omadacycline, a first-in-class aminomethylcycline antibiotic with a broad spectrum of activity against Gram-positive, Gram-negative, anaerobic, and atypical bacteria, were evaluated in rats.
Lin, Wen, Flarakos, Jimmy, Du, Yancy, Hu, Wenyu, He, Handan, Mangold, James, Tanaka, S. Ken, Villano, Stephen   +7 more
openaire   +2 more sources

Polymorphic Clinical and Pathological Presentation of Nontuberculous Mycobacteria: A Case Series

Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.
Background Nontuberculous mycobacteria (NTM) are a group of mycobacteria widely distributed in the environment. They may cause cutaneous infections in immunocompromised and immunocompetent hosts. Clinical presentations can be significantly heterogeneous and are not species‐specific; moreover, histological features can vary, probably depending on host ...
Gabriele Biondi, Martina Uda, Lavinia Bazzoni, Rosanna Rita Satta, Ioannis D. Bassukas   +4 more
wiley   +1 more source

Omadacycline for the treatment of patients with Legionella pneumophila pneumonia after experiencing liver dysfunction: case series

Frontiers in Microbiology
IntroductionAntibiotics frequently induce abnormal liver function. Omadacycline is a novel aminomethylcycline antibiotic, which shows potent activity against Gram-positive and Gram-negative aerobic, anaerobic, and atypical (including Legionella ...
Ani Zhu, Qian Ma, Zhiyan Liu
doaj   +1 more source

Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT A series of novel tetracycline derivatives were synthesized with the goal of creating new antibiotics that would be unaffected by the known tetracycline resistance mechanisms. New C-9-position derivatives of minocycline (the aminomethylcyclines [AMCs]) were tested for in vitro activity against ...
Honeyman, Laura, Ismail, Mohamed, Nelson, Mark L., Bhatia, Beena, Bowser, Todd E., Chen, Jackson, Mechiche, Rachid, Ohemeng, Kwasi, Verma, Atul K., Cannon, E. Pat, Macone, Ann, Tanaka, S. Ken, Levy, Stuart   +12 more
openaire   +2 more sources