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Resistance mechanisms of tigecycline in Acinetobacter baumannii [PDF]

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
Acinetobacter baumannii is widely distributed in nature and in hospital settings and is a common pathogen causing various infectious diseases. Currently, the drug resistance rate of A.
Chunli Sun   +7 more
doaj   +2 more sources

Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study

open access: yesJournal of Intensive Care, 2023
Background Tigecycline has in vitro bacteriostatic activity against a broad spectrum of bacteria, including carbapenem-resistant Gram-negative bacteria (CR-GNB).
Kuang-Yao Yang   +10 more
doaj   +1 more source

Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China

open access: yesMicrobiology Spectrum, 2021
We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang   +7 more
doaj   +1 more source

Antibiotic Resistance and Biofilm‐Forming Capacity of Oral Biofilm Bacteria in Patients With Periodontitis and Healthy Individuals

open access: yesMicrobiologyOpen, Volume 15, Issue 5, October 2026.
Key finding: Antimicrobial resistance was common across all groups and associated with biofilm‐forming capacity, an association that remains observational and species‐confounded. ABSTRACT This study aimed to analyse antimicrobial resistance (AMR) in bacterial isolates from subgingival biofilms of patients with periodontitis and supragingival biofilms ...
Nils Werner   +9 more
wiley   +1 more source

Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug‐Resistant Bacteria: Preliminary Antibiotic–Interaction Screening and Exploratory Molecular Docking

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The methanolic extract of Cinnamomum verum exhibited antibacterial and antibiofilm activities, enhanced the efficacy of conventional antibiotics against multidrug‐resistant bacteria, and showed favorable interactions with key bacterial targets in molecular docking analyses, supporting its potential as a natural antimicrobial adjuvant for combating ...
Hayet Edziri   +11 more
wiley   +1 more source

Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 2016
: INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years.
Yin Yuhan   +4 more
doaj   +1 more source

Postoperative Takotsubo Cardiomyopathy in a Young Woman: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 9, September 2026.
Timeline of the patient's clinical course. ABSTRACT Takotsubo cardiomyopathy (TCM) can occur in young adults exposed to extreme physical stress, such as surgery, sepsis, and transfusion reactions. Mechanical recovery may precede electrical normalization, with ECG abnormalities persisting despite improved left ventricular ejection fraction (LVEF). Early
Nadia Siddiq   +6 more
wiley   +1 more source

The Rapid Emergence of Tigecycline Resistance in blaKPC–2 Harboring Klebsiella pneumoniae, as Mediated in Vivo by Mutation in tetA During Tigecycline Treatment

open access: yesFrontiers in Microbiology, 2018
Tigecycline is one of the last resort treatments for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. Tigecycline resistance often occurs during the clinical treatment of CRKP, yet its mechanism has still not been clearly elucidated.
Xiaoxing Du   +6 more
doaj   +1 more source

Aetiology and Antibiotic Susceptibility of Common Bacterial Infections in Hospitalised Patients: A 2019 Multisite Cross‐Sectional Survey in Jakarta, Indonesia

open access: yesTropical Medicine &International Health, Volume 31, Issue 9, Page 1231-1237, September 2026.
ABSTRACT Objectives To describe the aetiology and antibiotic susceptibility patterns of common bacterial infections in hospitalised patients in Jakarta, Indonesia. Methods We conducted a hospital‐wide point prevalence survey in six hospitals in 2019, capturing data from routinely ordered bacterial cultures taken before the start of antibiotic treatment.
Justin de Brabander   +36 more
wiley   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari   +2 more
wiley   +1 more source

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