Results 1 to 10 of about 22,607 (134)

Tigecycline Heteroresistance and Resistance Mechanism in Clinical Isolates of Acinetobacter baumannii

open access: yesMicrobiology Spectrum, 2021
Tigecycline is regarded as a last-resort treatment for multidrug-resistant Acinetobacter baumannii. However, tigecycline resistance in A. baumannii has increased worldwide. In this study, we investigated tigecycline heteroresistance in A.
Kwan Soo Ko
exaly   +3 more sources

A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
The increasing incidence of tigecycline resistance undoubtedly constitutes a serious threat to global public health. The combination therapies had become the indispensable strategy against this threat. Herein, 11 clinical tigecycline-resistant Klebsiella
Lang Sun, Xiukun Wang, Tongying Nie
exaly   +3 more sources

Effect of sub-inhibitory tigecycline (½-MIC) on AcrAB-TolC and mar/ram/sox regulatory genes in Enterobacter cloacae complex isolates [PDF]

open access: yesFrontiers in Cellular and Infection Microbiology
The global rise of antimicrobial resistance (AMR) in Enterobacterales, including the Enterobacter cloacae complex, is narrowing treatment options.
Lukasz Korczak   +4 more
doaj   +2 more sources

Tigecycline for severe Clostridium difficile infection

open access: yesInternational Journal of Infectious Diseases, 2014
Limited data suggest that tigecycline may be of value in the treatment of Clostridiumdifficile infection. We reviewed our experience using tigecycline to treat severe c.
Nizam Uddin, Mark R Wallace
exaly   +3 more sources

Developmental dynamics of antibiotic resistome in aerobic biofilm microbiota treating wastewater under stepwise increasing tigecycline concentrations

open access: yesEnvironment International, 2019
This study aimed to investigate the impact of tigecycline, the third generation tetracycline, on the antibiotic resistance development in environmental microbiota.
Ruyin Liu, Min Yang, Yu Zhang
exaly   +3 more sources

Tigecycline [PDF]

open access: yesJournal of Antimicrobial Chemotherapy, 2005
New antimicrobial agents are urgently needed for clinical use due to the increasing prevalence and spread of multidrug-resistant bacteria that are commonly responsible for serious and life-threatening diseases. The need to develop new agents that effectively overcome existing mechanisms of resistance displayed by bacteria resistant to currently ...
James E, Frampton, Monique P, Curran
  +7 more sources

Fitness Costs of Tigecycline Resistance in Acinetobacter baumannii and the Resistance Mechanism Revealed by a Transposon Mutation Library

open access: yesAntibiotics, 2022
Acinetobacter baumannii is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant A.
Ping Wang   +5 more
doaj   +1 more source

Comparison of bleeding risk and hypofibrinogenemia-associated risk factors between tigecycline with cefoperazone/sulbactam therapy and other tigecycline-based combination therapies

open access: yesFrontiers in Pharmacology, 2023
Background: Tigecycline and cefoperazone/sulbactam can cause coagulation disorders; tigecycline may also lead to hypofibrinogenemia, raising safety concerns.
Lei Zhang   +6 more
doaj   +1 more source

Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients

open access: yesMicrobiology Spectrum, 2022
Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii
Jiangang Zhang   +8 more
doaj   +1 more source

Tigecycline

open access: yesJournal of Postgraduate Medicine, 2009
Infection with resistant pathogens can adversely affect clinical, microbiological and economic outcomes. New agents for the treatment of many such serious infections are acutely needed in hospital practice. Tigecycline is a novel glycylcycline antimicrobial for intravenous use.
Bhattacharya, M., Parakh, A., Narang, M.
  +5 more sources

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