Results 11 to 20 of about 26,995 (192)

Five-Years Tigecycline Experience an Analysis of Real-Life Data [PDF]

Haseki Tıp Bülteni, 2018
Aim: Tigecycline has been approved by the Food and Drug Administration for the treatment of complicated intra-abdominal infections, skin and soft tissue infections and community-acquired pneumonia.
Fatih Temocin, Necla Eren Tülek, Şirin Hekimoğlu, Tuba Ilgar, Cemal Bulut, Fatma Şebnem Erdinç, Günay Tuncer Ertem, Çiğdem Ataman Hatipoğlu, Sami Kınıklı   +8 more
doaj   +2 more sources

Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae.

PLoS ONE, 2015
KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one of the antibiotics recommended for severe infections caused by KPC-producing K. pneumoniae.
Fang He, Ying Fu, Qiong Chen, Zhi Ruan, Xiaoting Hua, Hua Zhou, Yunsong Yu   +6 more
doaj   +2 more sources

The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure [PDF]

Journal of Global Antimicrobial Resistance, 2023
: Objectives: We describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved. Material and methods: The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res).
Kristin Hegstad, Anna K. Pöntinen, Jørgen V. Bjørnholt, Else Quist-Paulsen, Arnfinn Sundsfjord   +4 more
doaj   +3 more sources

Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Acinetobacter baumannii Isolates

Infection and Drug Resistance
Xiaoxia Li,1,* Junnian Liu,2,* Xinyu Zhang,1 Juan Li,3 Luhan Xuan,1 Sue Yuan,1 Jianglin Li,1 Yu Sun,1 Xuefei Du1 1Clinical Laboratory, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of
Li X, Liu J, Zhang X, Li J, Xuan L, Yuan S, Li J, Sun Y, Du X   +8 more
doaj   +2 more sources

Tigecycline Treatment In Critically Ill Children: A Single-Center Experience

Journal of Global Antimicrobial Resistance
AIM: We aimed to draw attention to the fact that tigecycline may be an alternative in the treatment of resistant gram-negative infections in children.
Neslihan Mete Atasever, Elif Dede, Mavera Uşaklıoğlu Erol, Ayper Somer, Selda Hançerli Törün   +4 more
doaj   +2 more sources

Immunomodulatory Effects of Tigecycline in Balb/C Mice

Acta Pharmaceutica, 2018
Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for
Elhayek Shada Y., Fararjeh Mohammad A., Assaf Areej M., Abu-Rish Eman Y., Bustanji Yasser   +4 more
doaj   +2 more sources

Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline

Nature Communications
Tigecycline is widely used for treating complicated bacterial infections for which there are no effective drugs. It inhibits bacterial protein translation by blocking the ribosomal A-site.
Xiang Li, Mengjiao Wang, Timo Denk, Robert Buschauer, Yi Li, Roland Beckmann, Jingdong Cheng   +6 more
doaj   +2 more sources

Antimicrobial Photodynamic Therapy With New Methylene Blue and Its Combined Effect With Antibiotics Against MDR Acinetobacter baumannii. [PDF]

Microbiologyopen
NMB‐mediated aPDT significantly inhibited MDR A. baumannii and enhanced the efficacy of tigecycline and colistin through synergistic or additive interactions. Increased ROS generation during aPDT and combination therapy may contribute to the observed antibacterial effects.
Barati B, Navidifar T, Ostovari M, Ghanavati R, Darbandi A.   +4 more
europepmc   +2 more sources

Antibiotic Resistance and Biofilm Gene Distribution in Colistin-Resistant Acinetobacter baumannii. [PDF]

Microbiologyopen
Multicenter analysis of 144 clinical Acinetobacter baumannii isolates in Iran revealed high MDR/XDR rates and widespread biofilm formation (90.9%). Colistin resistance was linked to pmrAB overexpression, while blaPER‐1 was independently associated with strong biofilm production, highlighting chromosomal resistance mechanisms and biofilm as key drivers ...
Hatem ZA, Kafe FN, Musa FH, Al-Taie SF, Ateya NH, Aziz LM, Rajabi E, Hasan RN.   +7 more
europepmc   +2 more sources

Hospital-Associated Antimicrobial Resistant Bacteria on 95 Mobile Phones: An International Metagenomic "Phonome" Analysis. [PDF]

Microbiologyopen
On average, phones harbored 3.62 of the top 10 killers and 2.49 ESKAPE organisms. In total, 667 VFGs (8621 Hits) and 262 ARGs (2475 Hits) were identified on 95 mobile phones. Mobile phones serve as a platform for horizontal gene transfer and AMR development.
Goldsworthy A, Olsen M, Obonyo NG, Jones P, McKirdy S, Senok A, Alghafri R, Ghemrawi R, Almheiri R, Tronstad O, Suen JY, Fraser JF, Tajouri L.   +12 more
europepmc   +2 more sources