The tigecycline resistance mechanisms in Gram-negative bacilli [PDF]
Frontiers in Cellular and Infection MicrobiologyTigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli.
Zhiren Wang, Zhiren Wang, Henan Li
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Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus [PDF]
Microbiology Spectrum, 2023 Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years.
Honghao Huang +6 more
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Fitness Costs of Tigecycline Resistance in Acinetobacter baumannii and the Resistance Mechanism Revealed by a Transposon Mutation Library [PDF]
Antibiotics, 2022 Acinetobacter baumannii is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant A.
Ping Wang +5 more
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A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae [PDF]
Microbiology SpectrumThis study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu +8 more
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Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis
Frontiers in Veterinary Science, 2021 The aim of this study was to gain insight into the resistance determinants conferring resistance to tigecycline in Streptococcus (S.) suis and to investigate the genetic elements involved in their horizontal transfer. A total of 31 tetracycline-resistant
Rui Yu +6 more
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Resistance mechanisms of tigecycline in Acinetobacter baumannii
Frontiers in Cellular and Infection Microbiology, 2023 Acinetobacter baumannii is widely distributed in nature and in hospital settings and is a common pathogen causing various infectious diseases. Currently, the drug resistance rate of A.
Chunli Sun +7 more
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Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides [PDF]
Frontiers in Microbiology, 2021 Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of ...
Hua-le Chen +9 more
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Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China [PDF]
Microbiology Spectrum, 2021 We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang +7 more
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Journal of Global Antimicrobial Resistance, 2022 : Objectives: This study investigated the underlying mechanism of the evolution of tigecycline resistance during treatment in a patient infected with Klebsiella pneumoniae harbouring blaKPC-2. Methods: A total of seven clonal K.
Wenli Liao +8 more
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mSystems, 2021 The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the ...
Chao-Yue Cui +13 more
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