The tigecycline resistance mechanisms in Gram-negative bacilli [PDF]
Frontiers in Cellular and Infection MicrobiologyTigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli.
Zhiren Wang, Zhiren Wang, Henan Li
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Molecular mechanisms of tigecycline-resistance among Enterobacterales [PDF]
Frontiers in Cellular and Infection MicrobiologyThe global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous ...
Lukasz Korczak +9 more
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Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus [PDF]
Microbiology Spectrum, 2023 Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years.
Honghao Huang +6 more
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Fitness Costs of Tigecycline Resistance in Acinetobacter baumannii and the Resistance Mechanism Revealed by a Transposon Mutation Library [PDF]
Antibiotics, 2022 Acinetobacter baumannii is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant A.
Ping Wang +5 more
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A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae [PDF]
Microbiology SpectrumThis study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu +8 more
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Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides [PDF]
Frontiers in Microbiology, 2021 Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of ...
Hua-le Chen +9 more
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Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China [PDF]
Microbiology Spectrum, 2021 We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang +7 more
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Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster tmexC2D2.2-toprJ2 Identified in Chromosome of Aeromonas spp. [PDF]
Microbiology Spectrum, 2022 The appearance and prevalence of novel plasmid-encoded tigecycline resistance efflux pump gene clusters tmexC1D1-toprJ1 and tmexC2D2-toprJ2 in Enterobacteriaceae have raised a threat to public health.
Cheng-Zhen Wang +8 more
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Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections [PDF]
Microbial Cell FactoriesBackground A novel plasmid-mediated resistance–nodulation–division (RND) efflux pump gene cluster tmexCD1-toprJ1 in Klebsiella pneumoniae tremendously threatens the use of convenient therapeutic options in the post-antibiotic era, including the “last ...
Jindian Yang# +7 more
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Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli [PDF]
Microbiology SpectrumThe rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet(X3) gene conferring high-level tigecycline resistance is deeply concerning. Here, we report
Jing Sun +14 more
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