Results 11 to 20 of about 19,887 (159)

Molecular mechanisms of tigecycline-resistance among Enterobacterales [PDF]

Frontiers in Cellular and Infection Microbiology
The global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous ...
Lukasz Korczak, Piotr Majewski, Dominika Iwaniuk, Pawel Sacha, Mariola Matulewicz, Piotr Wieczorek, Paulina Majewska, Anna Wieczorek, Piotr Radziwon, Elzbieta Tryniszewska   +9 more
doaj   +4 more sources

Induction of Tigecycline Resistance in Acinetobacter baumannii

Bio-Protocol, 2014
Multidrug resistance Acinetobacter baumannii (A. baumannii) (MDRAB) has emerged as a serious threat in hospitals in recent years. Currently, there are few antibiotics, including tigecycline, available to treat infections caused by MDRAB effectively. Both
Ming-Feng Lin, Yun-You Lin, Chung-Yu Lan
doaj   +2 more sources

Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae.

PLoS ONE, 2015
KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one of the antibiotics recommended for severe infections caused by KPC-producing K. pneumoniae.
Fang He, Ying Fu, Qiong Chen, Zhi Ruan, Xiaoting Hua, Hua Zhou, Yunsong Yu   +6 more
doaj   +4 more sources

Emergence of tigecycline-resistant Klebsiella pneumoniae ST11 clone in patients without exposure to tigecycline

Journal of Infection in Developing Countries, 2021
Introduction: Tigecycline is a unique class of semi-synthetic glycylcyclines developed to treat infections caused by multidrug-resistant Klebsiella pneumoniae.
Rezvan Goodarzi, Mohammadreza Arabestani, Mohmmad Yousef Alikhani, Fariba Keramat, Babak Asghari   +4 more
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The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure

Journal of Global Antimicrobial Resistance
: Objectives: We describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved. Material and methods: The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res).
Kristin Hegstad, Anna K. Pöntinen, Jørgen V. Bjørnholt, Else Quist-Paulsen, Arnfinn Sundsfjord   +4 more
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Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster tmexC2D2.2-toprJ2 Identified in Chromosome of Aeromonas spp. [PDF]

Microbiology Spectrum, 2022
The appearance and prevalence of novel plasmid-encoded tigecycline resistance efflux pump gene clusters tmexC1D1-toprJ1 and tmexC2D2-toprJ2 in Enterobacteriaceae have raised a threat to public health.
Cheng-Zhen Wang, Xun Gao, Jie-Ying Tu, Lu-Chao Lv, Wen-Xian Pu, Xiao-Tong He, Yan-Xiang Jiao, Yu-Ting Deng, Jian-Hua Liu   +8 more
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Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections [PDF]

Microbial Cell Factories
Background A novel plasmid-mediated resistance–nodulation–division (RND) efflux pump gene cluster tmexCD1-toprJ1 in Klebsiella pneumoniae tremendously threatens the use of convenient therapeutic options in the post-antibiotic era, including the “last ...
Jindian Yang#, Lei Xu#, Yonglin Zhou, Minhe Cui, Dejun Liu, Jianfeng Wang, Yang Wang, Xuming Deng   +7 more
doaj   +2 more sources

Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli [PDF]

Microbiology Spectrum
The rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet(X3) gene conferring high-level tigecycline resistance is deeply concerning. Here, we report
Jing Sun, Yiming Liu, Jiashen Chang, Ying Liu, Luqi Li, Ran Jiang, Yihan Luo, Shuo Yang, Mei Yang, Xinglong Wang, Juan Wang, Xi Xia, Kangkang Guo, Zengqi Yang, Dongyang Ye   +14 more
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The Rapid Emergence of Tigecycline Resistance in blaKPC–2 Harboring Klebsiella pneumoniae, as Mediated in Vivo by Mutation in tetA During Tigecycline Treatment

Frontiers in Microbiology, 2018
Tigecycline is one of the last resort treatments for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. Tigecycline resistance often occurs during the clinical treatment of CRKP, yet its mechanism has still not been clearly elucidated.
Xiaoxing Du, Fang He, Qiucheng Shi, Feng Zhao, Juan Xu, Ying Fu, Yunsong Yu   +6 more
doaj   +3 more sources

Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris

Emerging Microbes and Infections, 2020
Tigecycline is one of the last-resort antibiotics to treat severe infections. Recently, tigecycline resistance has sporadically emerged with an increasing trend, and Tet(X) family represents a new resistance mechanism of tigecycline.
Yingying Cheng, Yong Chen, Yang Liu, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou   +11 more
doaj   +3 more sources