Results 11 to 20 of about 5,707,439 (181)
Antibiotics, 2022 Acinetobacter baumannii is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant A.
Ping Wang +5 more
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Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance [PDF]
Clinical Microbiology and Infection, 2014 Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients.
van Duin, D. +10 more
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Genetic Determinants of Tigecycline Resistance in Mycobacteroides abscessus
Antibiotics, 2022 Mycobacteroides abscessus (formerly Mycobacterium abscessus) is a clinically important, rapid-growing non-tuberculous mycobacterium notoriously known for its multidrug-resistance phenotype. The intrinsic resistance of M. abscessus towards first- and second-generation tetracyclines is mainly due to the over-expression of a tetracycline-degrading enzyme ...
Hien Fuh Ng, Yun Fong Ngeow
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Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial pathogens. The objectives of our study were to examine the potential of the Tet(A), Tet(K), Tet(M), and Tet(X) tetracycline resistance proteins to acquire mutations causing tigecycline resistance and to determine how this affects ...
Linkevicius, Marius +2 more
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Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis [PDF]
Frontiers in Veterinary Science, 2021 The aim of this study was to gain insight into the resistance determinants conferring resistance to tigecycline in Streptococcus (S.) suis and to investigate the genetic elements involved in their horizontal transfer. A total of 31 tetracycline-resistant
Rui Yu +6 more
doaj +2 more sources
Tigecycline: pharmacological concerns and resistance [PDF]
International Journal of Basic & Clinical Pharmacology, 2020 Tigecycline, a semisynthetic derivative of minocycline, has a broad spectrum of activity against both gram positive and gram negative multidrug resistant bacteria. The drug acts on 30S ribosomal subunit and inhibits protein synthesis. Since the drug has excellent tissue distribution, it is very useful for treatment of skin infections, intra-abdominal ...
Rama Paudel, Hari P. Nepal
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Emerging Microbes and Infections, 2021 Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua +12 more
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Induction of Tigecycline Resistance in Acinetobacter baumannii
Bio-Protocol, 2014 Multidrug resistance Acinetobacter baumannii (A. baumannii) (MDRAB) has emerged as a serious threat in hospitals in recent years. Currently, there are few antibiotics, including tigecycline, available to treat infections caused by MDRAB effectively. Both
Ming-Feng Lin, Yun-You Lin, Chung-Yu Lan
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mSystems, 2021 The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the ...
Chao-Yue Cui +13 more
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Journal of Infection in Developing Countries, 2021 Introduction: Tigecycline is a unique class of semi-synthetic glycylcyclines developed to treat infections caused by multidrug-resistant Klebsiella pneumoniae.
Rezvan Goodarzi +4 more
doaj +4 more sources