Results 21 to 30 of about 19,887 (159)
Genetic Determinants of Tigecycline Resistance in Mycobacteroides abscessus. [PDF]
Antibiotics (Basel), 2022 Mycobacteroides abscessus (formerly Mycobacterium abscessus) is a clinically important, rapid-growing non-tuberculous mycobacterium notoriously known for its multidrug-resistance phenotype. The intrinsic resistance of M. abscessus towards first- and second-generation tetracyclines is mainly due to the over-expression of a tetracycline-degrading enzyme ...
Ng HF, Ngeow YF.
europepmc +4 more sources
A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The increasing incidence of tigecycline resistance undoubtedly constitutes a serious threat to global public health. The combination therapies had become the indispensable strategy against this threat. Herein, 11 clinical tigecycline-resistant Klebsiella pneumoniae which mainly has mutations in ramR, acrR, or macB were collected for tigecycline ...
Lilan Sun +7 more
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Mechanisms of tigecycline resistance in Gram-negative bacteria: A narrative review [PDF]
Engineering MicrobiologyHai Xu, Chengzhang Fu, Xiuhua Pang
exaly +2 more sources
Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations. [PDF]
Front MicrobiolIntroductionThe emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.MethodsIn this study, we evaluated the synergism of ...
Liu J +8 more
europepmc +4 more sources
Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance [PDF]
Clinical Microbiology and Infection, 2014 Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients.
van Duin, D. +10 more
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Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial pathogens. The objectives of our study were to examine the potential of the Tet(A), Tet(K), Tet(M), and Tet(X) tetracycline resistance proteins to acquire mutations causing tigecycline resistance and to determine how this affects ...
Linkevicius, Marius +2 more
openaire +3 more sources
Microbiology Spectrum, 2021 Tigecycline is regarded as a last-resort treatment for multidrug-resistant Acinetobacter baumannii. However, tigecycline resistance in A. baumannii has increased worldwide. In this study, we investigated tigecycline heteroresistance in A.
Jeongwoo Jo, Kwan Soo Ko
doaj +1 more source
Emerging Microbes and Infections, 2021 Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua +12 more
doaj +1 more source
High tigecycline resistance in multidrug-resistant Acinetobacter baumannii [PDF]
Journal of Antimicrobial Chemotherapy, 2007 Multidrug-resistant (MDR) Acinetobacter baumannii is increasing in our hospital and worldwide, raising the necessity of finding effective therapies. We aimed to evaluate the in vitro activity of tigecycline against MDR A. baumannii clones isolated before tigecycline was used in our institution.Eighty-two unique patient clinical isolates of multidrug ...
Shiri, Navon-Venezia +2 more
openaire +2 more sources
Microbiology Spectrum, 2022 Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii
Jiangang Zhang +8 more
doaj +1 more source