Results 21 to 30 of about 30,783 (205)
Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance [PDF]
Clinical Microbiology and Infection, 2014 Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients.
van Duin, D. +10 more
openaire +2 more sources
High tigecycline resistance in multidrug-resistant Acinetobacter baumannii [PDF]
Journal of Antimicrobial Chemotherapy, 2007 Multidrug-resistant (MDR) Acinetobacter baumannii is increasing in our hospital and worldwide, raising the necessity of finding effective therapies. We aimed to evaluate the in vitro activity of tigecycline against MDR A. baumannii clones isolated before tigecycline was used in our institution.Eighty-two unique patient clinical isolates of multidrug ...
Shiri, Navon-Venezia +2 more
openaire +2 more sources
Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial pathogens. The objectives of our study were to examine the potential of the Tet(A), Tet(K), Tet(M), and Tet(X) tetracycline resistance proteins to acquire mutations causing tigecycline resistance and to determine how this affects ...
Linkevicius, Marius +2 more
openaire +3 more sources
Microbiology Spectrum, 2021 Tigecycline is regarded as a last-resort treatment for multidrug-resistant Acinetobacter baumannii. However, tigecycline resistance in A. baumannii has increased worldwide. In this study, we investigated tigecycline heteroresistance in A.
Jeongwoo Jo, Kwan Soo Ko
doaj +1 more source
Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations. [PDF]
Front MicrobiolIntroductionThe emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.MethodsIn this study, we evaluated the synergism of ...
Liu J +8 more
europepmc +4 more sources
Emerging Microbes and Infections, 2021 Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua +12 more
doaj +1 more source
Successful Treatment of Acute Prostatitis Caused by Multidrug-Resistant Escherichia coli With Tigecycline Monotherapy [PDF]
, 2020 We present a successful treatment, with tigecycline monotherapy, of acute prostatitis caused by multidrug-resistant Escherichia coli harboring an NDM-1 carbapemenase along with a CMY-2 cephalosporinase and a TEM ...
Babouee Flury, Baharak +7 more
core +2 more sources
Susceptibility of Tigecycline against Carbapenem Resistant Enterobacteriaceae [PDF]
Pakistan Journal of Medicine and Dentistry, 2021 Background: Enterobacteriaceae, a large family of Gram-negative bacteria, are one of the commonest etiological agents causing serious bacterial infections to humans. Carbapenems are the group of antibiotics with a broad spectrum of antimicrobial action.
Madeeha Fatima +2 more
openaire +2 more sources
Confronting Tigecycline-Resistant Acinetobacter baumannii via Immunization Against Conserved Resistance Determinants [PDF]
Frontiers in Microbiology, 2020 Antimicrobial-resistant (AMR) bacterial infections, including those caused by Acinetobacter baumannii, have emerged as a clinical crisis worldwide. Immunization with AMR determinants has been suggested as a novel approach to combat AMR bacteria, but has not been validated.
Ming-Hsien Chiang +10 more
openaire +3 more sources
Microbiology Spectrum, 2022 Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii
Jiangang Zhang +8 more
doaj +1 more source