Results 21 to 30 of about 5,707,439 (181)

The Plasmid-Borne tet(A) Gene Is an Important Factor Causing Tigecycline Resistance in ST11 Carbapenem-Resistant Klebsiella pneumoniae Under Selective Pressure

Frontiers in Microbiology, 2021
The emergence and prevalence of tigecycline-resistant Klebsiella pneumoniae have seriously compromised the effectiveness of antimicrobial agents in the treatment of infections.
Juan Xu, Zhongliang Zhu, Yanmin Chen, Weizhong Wang, Fang He   +4 more
doaj   +2 more sources

Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections

Microbial Cell Factories
Background A novel plasmid-mediated resistance–nodulation–division (RND) efflux pump gene cluster tmexCD1-toprJ1 in Klebsiella pneumoniae tremendously threatens the use of convenient therapeutic options in the post-antibiotic era, including the “last ...
Jindian Yang#, Lei Xu#, Yonglin Zhou, Minhe Cui, Dejun Liu, Jianfeng Wang, Yang Wang, Xuming Deng   +7 more
doaj   +2 more sources

Mechanisms and fitness costs of tigecycline resistance in Escherichia coli [PDF]

Journal of Antimicrobial Chemotherapy, 2013
To stepwise select tigecycline-resistant Escherichia coli mutants in vitro, determine the mutation rates, identify the resistance mechanisms, determine the resistance level and cross-resistance to other antibiotic classes, evaluate the fitness costs of tigecycline resistance mechanisms and investigate if the same in vitro-identified target genes were ...
Linkevicius, M., Sandegren, L., Andersson, D. I.   +2 more
openaire   +3 more sources

Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Acinetobacter baumannii Isolates [PDF]

Infection and Drug Resistance
Xiaoxia Li,1,* Junnian Liu,2,* Xinyu Zhang,1 Juan Li,3 Luhan Xuan,1 Sue Yuan,1 Jianglin Li,1 Yu Sun,1 Xuefei Du1 1Clinical Laboratory, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of
Li X, Liu J, Zhang X, Li J, Xuan L, Yuan S, Li J, Sun Y, Du X   +8 more
doaj   +1 more source

In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo . We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae
Spanu, Ta, De Angelis, Gb, Cipriani, Mb, Pedruzzi, Bb, D'Inzeo, Ta, Cataldo, MAbd, Sganga, Gc, Tacconelli, Eb   +15 more
openaire   +5 more sources

Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations [PDF]

Frontiers in Microbiology
IntroductionThe emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.MethodsIn this study, we evaluated the synergism of ...
Juan Liu, Juan Liu, Juan Liu, Si-Lin Zheng, Si-Lin Zheng, Jing-Jing Wu, Jing-Jing Wu, Mei Zheng, Mei Zheng, Mei Zheng, Da-Tong Cai, Da-Tong Cai, Yan Zhang, Yan Zhang, Jian Sun, Jian Sun, Jian Sun, Xiao-Ping Liao, Xiao-Ping Liao, Xiao-Ping Liao, Yang Yu, Yang Yu, Yang Yu   +22 more
openaire   +4 more sources

Evolution of tigecycline resistance inKlebsiella pneumoniaein a single patient [PDF]

Annals of Saudi Medicine, 2010
Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended ...
Al-Qadheeb Nada, Althawadi Sahar, Alkhalaf Abdulaziz, Hosaini Suleiman, Alrajhi Abdulrahman   +4 more
openaire   +4 more sources

A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
The increasing incidence of tigecycline resistance undoubtedly constitutes a serious threat to global public health. The combination therapies had become the indispensable strategy against this threat. Herein, 11 clinical tigecycline-resistant Klebsiella pneumoniae which mainly has mutations in ramR, acrR, or macB were collected for tigecycline ...
Lilan Sun, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang, Xuefu You   +7 more
openaire   +3 more sources

Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

, 2015
Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades.
Linkevičius, Marius
core   +4 more sources

Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides

Frontiers in Microbiology, 2021
Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of ...
Hua-le Chen, Hua-le Chen, Yan Jiang, Mei-mei Li, Yao Sun, Jian-ming Cao, Cui Zhou, Xiao-xiao Zhang, Yue Qu, Tie-li Zhou   +9 more
doaj   +1 more source