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Clinical application and drug resistance mechanism of gemcitabine [PDF]
Frontiers in Cell and Developmental BiologyGemcitabine, as a nucleoside analog, exerts a broad-spectrum antitumor effect by interfering with DNA synthesis, but its clinical application is limited by drug resistance.
Xuanrui Zhang, Bing Qi, Jing Chen
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Drug Resistance Mechanism among Acinetobacter Species
Journal of Pure and Applied Microbiology, 2021 Acinetobacter species cause infections that are difficult to control due to multi-drug resistance and are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance for the production of beta-lactamases
S. Jayashree +2 more
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Frontiers in Oncology, 2022 Non-small-cell lung cancer (NSCLC) is the most common cancer in the world. In recent years, the incidence of synchronous multiple primary lung cancer (SMPLC) has gradually increased. Surgery is the preferred method to treat these patients. The management
Shaonan Xie, Qingyi Liu
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Frontiers in Oncology, 2023 BackgroundHER2-targeted therapy provides survival benefits to HER2-mutant non-small cell lung cancer (NSCLC). A better understanding of the clinical and genomic characterization of treatment-naïve HER2-positive NSCLC, as well as the efficacy of and ...
Yanjie Han +8 more
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Annals of Translational Medicine, 2016 By definition, the terms sepsis and septic shock refer to a potentially fatal infectious state in which the early administration of an effective antibiotic is the most significant determinant of the outcome. Because of the global spread of resistant bacteria, the efficacy of antibiotics has been severely compromised. S.
Yasemin, Cag +4 more
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Chemotherapy Resistance Mechanisms [PDF]
Acta Oncologica, 1996 Resistance to chemotherapy is a major problem in oncology. The drug resistance in breast cancer shares most traits with other solid tumours. As a result of studies of cell lines and animal tumours a number of drug resistance factors have been identified but only limited data from human tumours are available.
U, Ringborg, A, Platz
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The Influencing Factors of Bacterial Resistance Related to Livestock Farm: Sources and Mechanisms
Frontiers in Animal Science, 2021 Bacterial resistance is a complex scientific issue. To manage this issue, we need to deeply understand the influencing factors and mechanisms. Based on the background of livestock husbandry, this paper reviews the factors that affect the acquisition of ...
Kaixuan Guo +14 more
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Mechanisms of tamoxifen resistance [PDF]
Endocrine-Related Cancer, 2004 The anti-oestrogen tamoxifen is the most commonly used treatment for patients with oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from tamoxifen in the adjuvant and metastatic settings, resistance is an important clinical problem. The target of tamoxifen in vivo is the ER.
Alistair, Ring, Mitch, Dowsett
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Frontiers in Plant Science, 2022 Following infestation by Verticillium wilt, alfalfa (Medicago sativa L.) often shows symptoms such as disease spots, leaf loss, stem, and leaf yellowing, resulting in the decline of alfalfa yield and quality and causing significant losses to the alfalfa ...
Fang Li +6 more
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Frontiers in Plant Science, 2022 The two-spotted spider mite (TSSM) is a destructive cassava pest. Intensive demonstration of resistance mechanism greatly facilitates the creation of TSSM-resistant cassava germplasm.
Qing Chen +28 more
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