Results 1 to 10 of about 2,975,301 (351)

Clinical application and drug resistance mechanism of gemcitabine [PDF]

Frontiers in Cell and Developmental Biology
Gemcitabine, as a nucleoside analog, exerts a broad-spectrum antitumor effect by interfering with DNA synthesis, but its clinical application is limited by drug resistance.
Xuanrui Zhang, Bing Qi, Jing Chen
doaj   +2 more sources

Drug Resistance Mechanism among Acinetobacter Species

Journal of Pure and Applied Microbiology, 2021
Acinetobacter species cause infections that are difficult to control due to multi-drug resistance and are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance for the production of beta-lactamases
S. Jayashree, K.G. Rajeshwari, Mita D. Wadekar   +2 more
doaj   +1 more source

Case report: Different mechanisms of drug resistance in a synchronous multiple primary lung cancer patient after EGFR-TKI treatment

Frontiers in Oncology, 2022
Non-small-cell lung cancer (NSCLC) is the most common cancer in the world. In recent years, the incidence of synchronous multiple primary lung cancer (SMPLC) has gradually increased. Surgery is the preferred method to treat these patients. The management
Shaonan Xie, Qingyi Liu
doaj   +1 more source

Genomic landscape and efficacy of HER2-targeted therapy in patients with HER2-mutant non-small cell lung cancer

Frontiers in Oncology, 2023
BackgroundHER2-targeted therapy provides survival benefits to HER2-mutant non-small cell lung cancer (NSCLC). A better understanding of the clinical and genomic characterization of treatment-naïve HER2-positive NSCLC, as well as the efficacy of and ...
Yanjie Han, Yanjie Han, Yuanyuan Xiong, Tao Lu, Rongrong Chen, Yuan Liu, Hui Tang, Ruixuan Geng, Yingyi Wang   +8 more
doaj   +1 more source

The Influencing Factors of Bacterial Resistance Related to Livestock Farm: Sources and Mechanisms

Frontiers in Animal Science, 2021
Bacterial resistance is a complex scientific issue. To manage this issue, we need to deeply understand the influencing factors and mechanisms. Based on the background of livestock husbandry, this paper reviews the factors that affect the acquisition of ...
Kaixuan Guo, Kaixuan Guo, Yue Zhao, Yue Zhao, Luqing Cui, Luqing Cui, Zhengzheng Cao, Zhengzheng Cao, Fan Zhang, Fan Zhang, Xiangru Wang, Jiawei Feng, Jiawei Feng, Menghong Dai, Menghong Dai   +14 more
doaj   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +7 more sources

Transcriptome Analysis Revealed the Molecular Response Mechanism of High-Resistant and Low-Resistant Alfalfa Varieties to Verticillium Wilt

Frontiers in Plant Science, 2022
Following infestation by Verticillium wilt, alfalfa (Medicago sativa L.) often shows symptoms such as disease spots, leaf loss, stem, and leaf yellowing, resulting in the decline of alfalfa yield and quality and causing significant losses to the alfalfa ...
Fang Li, Xi Chen, Bo Yang, Yingjie Guang, Dandan Wu, Zunji Shi, Yanzhong Li   +6 more
doaj   +1 more source

Overexpression of leucoanthocyanidin reductase or anthocyanidin reductase elevates tannins content and confers cassava resistance to two-spotted spider mite

Frontiers in Plant Science, 2022
The two-spotted spider mite (TSSM) is a destructive cassava pest. Intensive demonstration of resistance mechanism greatly facilitates the creation of TSSM-resistant cassava germplasm.
Qing Chen, Qing Chen, Xiao Liang, Xiao Liang, Chunling Wu, Chunling Wu, Ying Liu, Ying Liu, Xiaoqiang Liu, Xiaoqiang Liu, Huiping Zhao, Huiping Zhao, Kaimian Li, Songbi Chen, Haiyan Wang, Zhiling Han, Zhiling Han, Mufeng Wu, Mufeng Wu, Xiaowen Yao, Xiaowen Yao, Jun Shui, Jun Shui, Yang Qiao, Yang Qiao, Xue Zhan, Xue Zhan, Yao Zhang, Yao Zhang   +28 more
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Transcriptomic and Metabolomic Analyses Reveal a Potential Mechanism to Improve Soybean Resistance to Anthracnose

Frontiers in Plant Science, 2022
Anthracnose, caused by Colletotrichum truncatum, leads to large-scale reduction in quality and yield in soybean production. Limited information is available regarding the molecular mechanisms of resistance to anthracnose in soybean.
Longming Zhu, Qinghua Yang, Xiaomin Yu, Xujun Fu, Hangxia Jin, Fengjie Yuan   +5 more
doaj   +1 more source

Research Progress of Epigenetic Mechanism in Acquired Resistance of 
Targeted Therapy in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2021
Patients with oncogenic driver alterations of non-small cell lung cancer (NSCLC) can benefit from targeted therapy, but acquired resistance is inevitable ultimately.
Xin AI, Yan WANG
doaj   +1 more source