Results 31 to 40 of about 2,975,301 (351)

Mechanisms of Immune Resistance [PDF]

, 2018
AbstractRelapse represents one of the main unsolved issues in allogeneic HCT, prompting research on its underlying mechanisms. Growing evidence support the hypothesis that in many patients relapse is driven by immune changes in cancer cells and in the supporting microenvironment, abrogating the graft-versus-tumor effect.
Vago L., Dazzi F.
openaire   +3 more sources

Mechanisms of antidepressant resistance [PDF]

Frontiers in Pharmacology, 2013
Depression is one of the most frequent and severe mental disorder. Since the discovery of antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds, several classes of psychotropic drugs have shown be effective in treating major depressive disorder (MDD).
El-Hage, Wissam, Leman, Samuel, Camus, Vincent, Belzung, Catherine   +3 more
openaire   +5 more sources

Mechanisms of Taxane Resistance [PDF]

Cancers, 2020
The taxane family of chemotherapy drugs has been used to treat a variety of mostly epithelial-derived tumors and remain the first-line treatment for some cancers. Despite the improved survival time and reduction of tumor size observed in some patients, many have no response to the drugs or develop resistance over time.
Sara M. Maloney, Camden A. Hoover, Lorena V. Morejon-Lasso, Jenifer R. Prosperi   +3 more
openaire   +2 more sources

Chimeric antigen receptor T-cell therapy for multiple myeloma

Frontiers in Immunology, 2022
Multiple myeloma (MM) is a malignant plasma cell disorder that remains incurable for most patients, as persistent clonal evolution drives new mutations which confer MM high-risk signatures and resistance to standard care.
Zehua Wang, Chen Chen, Lei Wang, Yongxu Jia, Yanru Qin   +4 more
doaj   +1 more source

Antifungal drug resistance mechanisms

Expert Review of Anti-infective Therapy, 2009
Antifungal resistance is a prominent feature in the management of invasive mycoses, with important implications for morbidity and mortality. Microbiological resistance, the most common cause of refractory infection, is associated with a fungal pathogen for which an antifungal MIC is higher than average or within the range designated as the resistant ...
Peman, Javier, Canton, Emilia, Espinel-Ingroff, Ana   +2 more
openaire   +4 more sources

Review of: "Inhibiting Efflux Pumps and Resistance Mechanisms: A Mini Review" [PDF]

, 2023
Claus‐Michael Lehr
openalex   +3 more sources

The Resistance Mechanisms of Anilinopyrimidine Fungicide Pyrimethanil in Sclerotinia sclerotiorum

Journal of Fungi
The necrotrophic pathogen Sclerotinia sclerotiorum is widely distributed and infects a broad range of hosts, making it one of the most economically damaging plant pathogens.
Yanfen Wang, Zeyuan Chen, Tiancheng Liu, Xupeng Gao, Yanchao Shi, Honghui Wu, Runqiang Liu, Yunchao Kan, Hao Yu, Feng Zhou   +9 more
doaj   +1 more source

Study on the mechanism of KRAS R68G secondary mutation-induced resistance to KRASG12D-targeted inhibitor MRTX1133

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the mechanism at the atomic level by which the KRASG12D/R68G mutation induces tumor cell resistance to MRTX1133.Methods·The crystal structure data of the KRASG12D-MRTX1133 complex were obtained from the RCSB Protein Data Bank (PDB ...
WANG Gaoming, CUI Ran, LI Yanjing, LIU Yingbin   +3 more
doaj   +1 more source

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

, 2014
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy.
A. Lorz, A. Lorz, A. Wu, A.L. Correia, A.O. Pisco, A.S. Silva, B. Baguley, C. Bock, D. Woods, D.W. McMillin, E.S. Nakasone, F.A. Meineke, G. Lambert, H. Zahreddine, H.M. Byrne, I. Bozic, J. Foo, J. Foo, J. Greene, J.J. Cunningham, J.J. Kim, J.J. Lee, K. Cheung-Ong, M. Dean, M. Sawicka, M.M. Hadjiandreou, N.L. Komarova, N.L. Komarova, O. Lavi, O. Lavi, O. Trédan, P. Karran, P.A. Orlando, P.P. Provenzano, S. Rottenberg, S.M. Mumenthaler, T. Brocato, T.L. Jackson   +37 more
core   +1 more source

Sensitivity Baselines, Resistance Monitoring, and Molecular Mechanisms of the Rice False Smut Pathogen Ustilaginoidea virens to Prochloraz and Azoxystrobin in Four Regions of Southern China

Journal of Fungi, 2023
Rice false smut caused by Ustilaginoidea virens is one of the most devastating fungal diseases of rice (Oryza sativa) worldwide. Prochloraz and azoxystrobin belong to the groups of demethylation inhibitors and quinone outside inhibitors, respectively ...
Anfei Fang, Ruixuan Zhang, Wei Qiao, Tao Peng, Yubao Qin, Jing Wang, Binnian Tian, Yang Yu, Wenxian Sun, Yuheng Yang, Chaowei Bi   +10 more
doaj   +1 more source