Results 51 to 60 of about 2,975,301 (351)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Advance in Drug Resistance Mechanism of Immune Checkpoint Inhibitors
Zhongliu Fangzhi Yanjiu, 2020 At present, immune-therapy, especially immune checkpoint inhibitors(ICI) therapy, has become a hot topic in cancer research field. With the wide application of ICI in the field of cancer, some patients benefit from ICI, some patients appeared disease ...
ZHANG Lanlan, LI Xiangmin, FAN Zaiwen
doaj +1 more source
Microbial Communities of the Providence River [PDF]
, 2015 The Providence River has been industrialized for over one-hundred years. Industries such as oil storage and metal recycling facilities have left high levels of pollutant metals, including lead (Pb), in the soil and water.
Kratch, Jacqueline
core +1 more source
Neuroendocrine mechanisms in insulin resistance [PDF]
Molecular and Cellular Endocrinology, 2009 Dysregulated hormonal, metabolic and neural signalling within and between organs can contribute to development of metabolic diseases including type 2 diabetes. Insulin-antagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen ...
Sjöstrand, Mikaela, Eriksson, Jan W.
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Equipartition of Current in Parallel Conductors on Cooling Through the Superconducting Transition
, 2006 Our experiments show that for two or more pieces of a wire, of different lengths in general, combined in parallel and connected to a dc source, the current ratio evolves towards unity as the combination is cooled to the superconducting transition ...
Bhat, S. V. +4 more
core +1 more source
The effect of environmental heterogeneity on RPW8-mediated resistance to powdery mildews in Arabidopsis thaliana [PDF]
, 2012 Background and Aims: The biotic and abiotic environment of interacting hosts and parasites may vary considerably over small spatial and temporal scales. It is essential to understand how different environments affect host disease resistance because this ...
Agrios +70 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Cells, 2022 Chimeric antigen receptor (CAR)-T cell therapy is undeniably a promising tool in combating various types of hematological malignancies. However, it is not yet optimal and a significant number of patients experience a lack of response or relapse after the
Katsiaryna Marhelava +3 more
doaj +1 more source
Persistence and resistance: survival mechanisms of Candidatus Dormibacterota from nutrient‐poor Antarctic soils [PDF]
, 2022 Kate Montgomery +7 more
openalex +1 more source