Results 71 to 80 of about 2,975,301 (351)

Mechanism of Insulin Resistance.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1999
インスリン抵抗性の成因は遺伝素因, 肥満などの生活習慣, 高血糖それ自体に大別される. 肥満に伴うインスリン抵抗性は肥大した脂肪細胞から分泌されるTNF-αや遊離脂肪酸 (FFA) が関与している. インスリン抵抗性の分子レベルでの共通の特徴は, (1)インスリン受容体チロシンキナーゼ・P13キナーゼ活性の低下, (2)GLUT4トランスロケーションと糖取り込み低下, (3)グリコーゲン合成酵素活性低下である. インスリン抵抗性は, 膵β細胞のインスリン分泌能や増殖能に障害のある場合には, 2型糖尿病の強力な発症要因となる. 最近, 糖代謝に関するインスリン作用に加えて, 血管や腎でのインスリン作用が解明されつつある.
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Variations in susceptibility to common insecticides and resistance mechanisms among morphologically identified sibling species of the malaria vector Anopheles subpictus in Sri Lanka

Parasites & Vectors, 2012
Background Anopheles subpictus s.l., an important malaria vector in Sri Lanka, is a complex of four morphologically identified sibling species A-D. Species A-D reportedly differ in bio-ecological traits that are important for vector control.
Surendran Sinnathamby N, Jude Pavilupillai J, Weerarathne Thilini C, Parakrama Karunaratne SHP, Ramasamy Ranjan   +4 more
doaj   +1 more source

Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance [PDF]

, 2012
Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components
A MacLeod, A Tait, Adalgisa Caccone, B Vanhollebeke, B Vanhollebeke, D Mehlitz, Daniel K. Masiga, DR Maddison, E Pays, EC Agbo, G Simo, HV Xong, JF Flot, Jon S. Beadell, Kehinde Agbebakun, L Vanhamme, M Clement, M Higgins, M Koffi, M Stephens, Mark Sistrom, O Balmer, Oliver Balmer, P Capewell, R Kieft, Rebecca E. Symula, RJ Wheeler, Serap Aksoy, SL Hajduk, W Gibson, WC Gibson, Wendy Gibson   +31 more
core   +3 more sources

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evolution of Target-Site Resistance to Glyphosate in an Amaranthus palmeri Population from Argentina and Its Expression at Different Plant Growth Temperatures

Plants, 2019
The mechanism and expression of resistance to glyphosate at different plant growing temperatures was investigated in an Amaranthus palmeri population (VM1) from a soybean field in Vicuña Mackenna, Cordoba, Argentina.
Shiv Shankhar Kaundun, Lucy Victoria Jackson, Sarah-Jane Hutchings, Jonathan Galloway, Elisabetta Marchegiani, Anushka Howell, Ryan Carlin, Eddie Mcindoe, Daniel Tuesca, Raul Moreno   +9 more
doaj   +1 more source

Synergistic Antibacterial Activity of Combined Antimicrobials and the Clinical Outcome of Patients With Carbapenemase-Producing Acinetobacter baumannii Infection

Frontiers in Microbiology, 2020
This study aimed to explore the activity of combined antimicrobials in vitro, and the relationship among resistance mechanisms, antimicrobial regimens, and the clinical outcome of patients with carbapenem-resistant Acinetobacter baumannii (CRAB ...
Junyan Qu, Rujia Yu, Qujue Wang, Chunlu Feng, Xiaoju Lv   +4 more
doaj   +1 more source