Data in Brief, 2016 This data article describes the anisotropy of diffraction observed for the centered monoclinic crystals of OmpF reported in “Two different centered monoclinic crystals of the E.
Vincent Chaptal +6 more
doaj +1 more source
Targeting tumor resistance mechanisms [PDF]
Faculty Reviews, 2021 Cancer develops resistance to treatments through many mechanisms. Single-cell analyses reveal the intratumor heterogeneity and dynamic relationships between cancer cell subpopulations. These analyses also highlight that various mechanisms of resistance may coexist in a given tumor.
Gerard, Louise +2 more
openaire +2 more sources
A passively adaptive screwdriver: a novel concept for controlling off-diagonal stiffness [PDF]
, 2006 A concept for an automated screw driving mechanism is presented. The proposed mechanism has a self-adjusting axial stiffness that depends on the torsional resistance against screwing.
Aitchison, D. R. +2 more
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Lack of phenotypic and evolutionary cross-resistance against parasitoids and pathogens in Drosophila melanogaster [PDF]
, 2012 BackgroundWhen organisms are attacked by multiple natural enemies, the evolution of a resistance mechanism to one natural enemy will be influenced by the degree of cross-resistance to another natural enemy.
A Fytrou +52 more
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Mechanisms of tamoxifen resistance [PDF]
Endocrine-Related Cancer, 2004 The anti-oestrogen tamoxifen is the most commonly used treatment for patients with oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from tamoxifen in the adjuvant and metastatic settings, resistance is an important clinical problem. The target of tamoxifen in vivo is the ER.
Alistair, Ring, Mitch, Dowsett
openaire +2 more sources
The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]
, 2019 Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin +9 more
core +1 more source
A novel sulfonamide resistance mechanism by two-component flavin-dependent monooxygenase system in sulfonamide-degrading actinobacteria [PDF]
, 2019 Sulfonamide-degrading bacteria have been discovered in various environments, suggesting the presence of novel resistance mechanisms via drug inactivation. In this study, Microbacterium sp.
Cha, Chang-Jun +4 more
core +1 more source
How innate immunity proteins kill bacteria and why they are not prone to resistance [PDF]
, 2017 Recent advances on antibacterial activity of peptidoglycan recognition proteins (PGRPs) offer some insight into how innate immunity has retained its antimicrobial effectiveness for millions of years with no frequent emergence of resistant strains. First,
Dziarski, Roman, Gupta, Dipika
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PARP Inhibitors in Ovarian Cancer: The Route to “Ithaca”
Diagnostics, 2019 Poly (ADP-ribose) polymerase (PARP) inhibitors are a novel class of therapeutic agents that target tumors with deficiencies in the homologous recombination DNA repair pathway.
Stergios Boussios +7 more
doaj +1 more source
Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]
, 2020 Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi +5 more
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