Results 21 to 30 of about 1,378,575 (268)

PARP Inhibitors in Ovarian Cancer: The Route to “Ithaca”

Diagnostics, 2019
Poly (ADP-ribose) polymerase (PARP) inhibitors are a novel class of therapeutic agents that target tumors with deficiencies in the homologous recombination DNA repair pathway.
Stergios Boussios, Afroditi Karathanasi, Deirdre Cooke, Cherie Neille, Agne Sadauskaite, Michele Moschetta, Nikolaos Zakynthinakis-Kyriakou, Nicholas Pavlidis   +7 more
doaj   +1 more source

Mechanisms of Taxane Resistance [PDF]

Cancers, 2020
The taxane family of chemotherapy drugs has been used to treat a variety of mostly epithelial-derived tumors and remain the first-line treatment for some cancers. Despite the improved survival time and reduction of tumor size observed in some patients, many have no response to the drugs or develop resistance over time.
Sara Maloney, Camden Spring, Lorena Morejon-Lasso, Jenifer Prosperi   +3 more
openaire   +2 more sources

The Resistance Mechanisms of Anilinopyrimidine Fungicide Pyrimethanil in Sclerotinia sclerotiorum

Journal of Fungi
The necrotrophic pathogen Sclerotinia sclerotiorum is widely distributed and infects a broad range of hosts, making it one of the most economically damaging plant pathogens.
Yanfen Wang, Zeyuan Chen, Tiancheng Liu, Xupeng Gao, Yanchao Shi, Honghui Wu, Runqiang Liu, Yunchao Kan, Hao Yu, Feng Zhou   +9 more
doaj   +1 more source

Study on the mechanism of KRAS R68G secondary mutation-induced resistance to KRASG12D-targeted inhibitor MRTX1133

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the mechanism at the atomic level by which the KRASG12D/R68G mutation induces tumor cell resistance to MRTX1133.Methods·The crystal structure data of the KRASG12D-MRTX1133 complex were obtained from the RCSB Protein Data Bank (PDB ...
WANG Gaoming, CUI Ran, LI Yanjing, LIU Yingbin   +3 more
doaj   +1 more source

Iterative Upgrading of Small Molecular Tyrosine Kinase Inhibitors for EGFR Mutation in NSCLC: Necessity and Perspective

Pharmaceutics, 2021
Molecular targeted therapy has been reported to have fewer adverse effects, and offer a more convenient route of administration, compared with conventional chemotherapy. With the development of sequencing technology, and research on the molecular biology
Jing Zhu, Qian Yang, Weiguo Xu
doaj   +1 more source

Mechanisms of resistance to osimertinib

Journal of Thoracic Disease, 2020
The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has significantly improved the prognosis of advanced non-small cell lung cancer (NSCLC) patients with EGFR mutations. The most common mechanism of acquired resistance to first- and second-generation EGFR TKIs is represented by the secondary T790M mutation ...
Lazzari C., Gregorc V., Karachaliou N., Rosell R., Santarpia M.   +4 more
openaire   +4 more sources

Mechanisms of Resistance to Cabazitaxel [PDF]

Molecular Cancer Therapeutics, 2015
Abstract We studied mechanisms of resistance to the novel taxane cabazitaxel in established cellular models of taxane resistance. We also developed cabazitaxel-resistant variants from MCF-7 breast cancer cells by stepwise selection in drug alone (MCF-7/CTAX) or drug plus the transport inhibitor PSC-833 (MCF-7/CTAX-P).
George E, Duran, Yan C, Wang, E Brian, Francisco, John C, Rose, Francisco J, Martinez, John, Coller, Diana, Brassard, Patricia, Vrignaud, Branimir I, Sikic   +8 more
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Molecular Mechanisms Underlying Resistance to Bacillus thuringiensis Cry Toxins in Lepidopteran Pests: An Updated Research Perspective

Agronomy
Genetically modified crops that produce insecticidal proteins from Bacillus thuringiensis (Bt) are currently the most efficient and safest method of pest control worldwide.
Deqin Hu, Dongmei Wang, Hongsheng Pan, Xiaoning Liu   +3 more
doaj   +1 more source