Results 31 to 40 of about 19,887 (159)

The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline. [PDF]

Int J Mol Sci
The presence of sub-minimal inhibitory concentration (sub-MIC) antibiotics in our environment is widespread, and their ability to induce antibiotic resistance is inevitable. Acinetobacter baumannii, a pathogen known for its strong ability to acquire antibiotic resistance, has recently shown clinical resistance to the last-line antibiotic tigecycline ...
Liu C, Liu J, Lu Q, Wang P, Zou Q.
europepmc   +3 more sources

Tigecycline: pharmacological concerns and resistance

International Journal of Basic & Clinical Pharmacology, 2020
Tigecycline, a semisynthetic derivative of minocycline, has a broad spectrum of activity against both gram positive and gram negative multidrug resistant bacteria.  The drug acts on 30S ribosomal subunit and inhibits protein synthesis. Since the drug has excellent tissue distribution, it is very useful for treatment of skin infections, intra-abdominal ...
Rama Paudel, Hari P. Nepal
openaire   +2 more sources

Comment on: High tigecycline resistance in multidrug-resistant Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2007
1. Seaman PF, Ochs D, Day MJ. Comment on: Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants: a novel mode of evasion of susceptibility to antiseptics. J Antimicrob Chemother 2007; doi:10.1093/jac/dkm118. 2. Bayston R, Ashraf W, Smith T.
Visanu, Thamlikitkul, Surapee, Tiengrim, Chanwit, Tribuddharat   +2 more
openaire   +2 more sources

Effect of ramR loss-of-function insertion on tigecycline resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2020
Objectives: Tigecycline is an antibacterial agent restricted for use against carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to identify the tigecycline resistance mechanism in clinical CRKP isolates obtained from a 60-year-old ...
Yihan Mao, Qiucheng Shi, Ping Zhang, Yan Jiang, Yunsong Yu   +4 more
doaj   +1 more source

Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Under the Pressure of Tigecycline

Frontiers in Microbiology, 2021
Colistin and tigecycline are the last options against carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). Intersecting resistance determinants have been detected between these antibiotics; however, there is only limited evidence of such ...
Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, Hui Wang   +7 more
doaj   +1 more source

Identification of Novel tet(X3) Variants Resistant To Tigecycline in Acinetobacter Species

Microbiology Spectrum, 2022
The emergence of the tet(X) gene is a severe challenge to global public health security, as clinical tigecycline resistance shows a rapidly rising trend. In this research, we identified two tigecycline-resistant Acinetobacter sp. strains containing seven
Yumeng Cheng, Yakun Li, Runhao Yu, Mingxiang Ma, Meng Yang, Hongbin Si   +5 more
doaj   +1 more source

1456. Resistance Mechanisms of Tigecycline in Enterococcus faecalis [PDF]

Open Forum Infectious Diseases, 2020
Abstract Background Enterococcus faecalis have been regarded as one of the leading causes of the nosocomial infections worldwide. Tigecycline (TGC) is considered as a choice of last resort for the treatment of infections caused by multidrug-resistant E.
Bai, Bing, Wen, Zewen, Lin, Zhiwei, H, Tam Vincent, Yu, Zhijian   +4 more
openaire   +1 more source

Susceptibility of Tigecycline against Carbapenem Resistant Enterobacteriaceae [PDF]

Pakistan Journal of Medicine and Dentistry, 2021
Background: Enterobacteriaceae, a large family of Gram-negative bacteria, are one of the commonest etiological agents causing serious bacterial infections to humans. Carbapenems are the group of antibiotics with a broad spectrum of antimicrobial action.
Madeeha Fatima, Faisal lqbal Afridi, Hareem Gohar   +2 more
openaire   +2 more sources

Once-a-week tigecycline for the treatment of drug-resistant TB [PDF]

Journal of Antimicrobial Chemotherapy, 2019
MDR-TB and XDR-TB have poor outcomes.To examine the efficacy of tigecycline monotherapy in the hollow fibre system model of TB.We performed pharmacokinetic/pharmacodynamic studies using tigecycline human-like concentration-time profiles in the hollow fibre system model of TB in five separate experiments using Mycobacterium tuberculosis in log-phase ...
Devyani Deshpande, Gesham Magombedze, Shashikant Srivastava, Paula Bendet, Pooi S Lee, Kayle N Cirrincione, Katherine R Martin, Keertan Dheda, Tawanda Gumbo   +8 more
openaire   +2 more sources

The Plasmid-Borne tet(A) Gene Is an Important Factor Causing Tigecycline Resistance in ST11 Carbapenem-Resistant Klebsiella pneumoniae Under Selective Pressure

Frontiers in Microbiology, 2021
The emergence and prevalence of tigecycline-resistant Klebsiella pneumoniae have seriously compromised the effectiveness of antimicrobial agents in the treatment of infections.
Juan Xu, Zhongliang Zhu, Yanmin Chen, Weizhong Wang, Fang He   +4 more
doaj   +1 more source