Results 51 to 60 of about 5,707,439 (181)

Susceptibility of Tigecycline against Carbapenem Resistant Enterobacteriaceae [PDF]

Pakistan Journal of Medicine and Dentistry, 2021
Background: Enterobacteriaceae, a large family of Gram-negative bacteria, are one of the commonest etiological agents causing serious bacterial infections to humans. Carbapenems are the group of antibiotics with a broad spectrum of antimicrobial action.
Madeeha Fatima, Faisal lqbal Afridi, Hareem Gohar   +2 more
openaire   +2 more sources

In vitro antimicrobial activity and resistance mechanisms of the new generation tetracycline agents, eravacycline, omadacycline, and tigecycline against clinical Staphylococcus aureus isolates

Frontiers in Microbiology, 2022
In this study, we investigated the in vitro activity and resistance mechanisms of the new generation tetracycline agents, namely eravacycline, omadacycline, and tigecycline, against Staphylococcus aureus isolates. A total of 1,017 non-duplicate S. aureus
Weiliang Zeng, Xiaotuan Zhang, Yan Liu, Yi Zhang, Mengxin Xu, Sipei Wang, Yao Sun, Tieli Zhou, Lijiang Chen   +8 more
doaj   +1 more source

Overview of tigecycline and its role in the era of antibiotic resistance [PDF]

Brazilian Journal of Infectious Diseases, 2006
The increasing antimicrobial resistance found in the many clinically important species of bacteria that commonly cause serious and life-threatening diseases presents a difficult challenge for clinicians, especially when an appropriate initial therapy must be chosen.
Rossi, Flávia, Andreazzi, Denise
openaire   +5 more sources

Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance

Nature Communications
Tigecycline is a last-resort antibiotic to treat complicated infections caused by multidrug-resistant pathogens, while the emergence of plasmid-mediated tet(X) family severely compromises its clinical efficacy.
Dan Fang, Tianqi Xu, Fulei Li, Yue Sun, Jingyi Sun, Yanqing Yin, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +8 more
semanticscholar   +1 more source

A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae

Microbiology Spectrum
This study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu, Qi Chen, Chenhao Zhao, Xin Ma, Lei Wang, Feinan Qian, Xiangyu Guan, Hong Du, Haifang Zhang   +8 more
doaj   +1 more source

Unraveling the evolution and global transmission of high level tigecycline resistance gene tet(X).

Environment International
An increasing number of tet(X) variants conferring tigecycline resistance have been reported, posing a threat to clinical treatment of multi-drug resistance bacteria as tigecycline serves as the last-resort antibiotic. In this study, a total of 721 tet(X)
Chaoqun Yao, Longyang Jin, Qi Wang, Meng Wang, Ruobing Wang, Meng Cai, Kaiwen Song, Hui Wang   +7 more
semanticscholar   +1 more source

Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene tet(X4) in Enterobacterales of Porcine Origin

Microbiology spectrum, 2022
Tigecycline is considered to be the last resort of defense against diseases caused by broad-spectrum resistant Gram-negative bacteria. In this study, we systematically analyzed the prevalence and genetic environments of the resistance gene tet(X4) in a ...
Qin Wang, Changwei Lei, Hansen Cheng, Xue Yang, Zheren Huang, Xuan Chen, Zijing Ju, Haoyu Zhang, Hongning Wang   +8 more
semanticscholar   +1 more source

Emergence of a Novel Plasmid-Mediated Tigecycline Resistance Gene Cluster, tmexCD4-toprJ4, in Klebsiella quasipneumoniae and Enterobacter roggenkampii

Microbiology spectrum, 2022
The plasmid-mediated tigecycline resistance gene cluster tmexCD1-toprJ1 and other variants have been detected in a variety of strains from multiple sources, including human-derived strains.
Xun Gao, Chengzhen Wang, Luchao Lv, Xiaoyong He, Zhongpeng Cai, Wanyun He, Tong Li, Jian-Hua Liu   +7 more
semanticscholar   +1 more source

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Journal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +1 more source

Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria

Microbiology spectrum, 2022
Recently, high-level tigecycline resistance mediated by tet(X4) and its variants represents a serious challenge for global public health. Antibiotic adjuvant strategy that enhances the activity of the existing antibiotics by using nonantibiotic drugs ...
Tian Deng, Yuqian Jia, Ziwen Tong, Jingru Shi, Zhiqiang Wang, Yuan Liu   +5 more
semanticscholar   +1 more source