Results 61 to 70 of about 19,887 (159)

Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens

Cell Reports
Summary: Tigecycline is a last-resort antibiotic primarily used to treat severe infections caused by multidrug-resistant (MDR) bacteria. However, the emergence of constantly appearing resistance determinants has drastically compromised its clinical ...
Feiyu Yu, Shuyao Zhu, Qingyang Lv, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
doaj   +1 more source

Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

Medicine Science, 2017
Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms.
Yucel Duman, Cigdem Kuzucu, Mehmet Sait Tekerekoglu   +2 more
doaj   +1 more source

Study on MICs of Tigecycline in Clinical Isolates of Carbapenem Resistant Enterobacteriaceae (CRE) at a Tertiary Care Centre in North India [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Members of family Enterobacteriaceae are the most common Gram-negative bacteria isolated from clinical samples. Those Enterobacteriaceae which have acquired resistance to all β-lactams antibiotics including the carbapenems are ...
Vineeta Khare, Prashant Gupta, Fareya Haider, Rehana Begum   +3 more
doaj   +1 more source

Aetiology and Antibiotic Susceptibility of Common Bacterial Infections in Hospitalised Patients: A 2019 Multisite Cross‐Sectional Survey in Jakarta, Indonesia

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives To describe the aetiology and antibiotic susceptibility patterns of common bacterial infections in hospitalised patients in Jakarta, Indonesia. Methods We conducted a hospital‐wide point prevalence survey in six hospitals in 2019, capturing data from routinely ordered bacterial cultures taken before the start of antibiotic treatment.
Justin de Brabander, Erni J. Nelwan, Ralalicia Limato, Monik Alamanda, Manzilina Mudia, Enty Tjoa, Ifael Y. Mauleti, Maria Mayasari, Iman Firmansyah, T. Mannaria Jayati, Michèle van Vugt, H. Rogier van Doorn, Raph L. Hamers, Erni J. Nelwan, Ralalicia Limato, Manzilina Mudia, Monik Alamanda, Helio Guterres, Enty Enty, Y. Ifael, Maria Mayasari Mauleti, Iman Firmansyah, May Hizrani, Anis Karuniawati, Taralan Tambunan, Amin Soebandrio, Decy Subekti, Iqbal Elyazar, Mutia Rahardjani, Fitria Wulandari, Reinout van Crevel, H. Rogier van Doorn, Vu Thi Lan Huong, Nga Do Ti Thuy, Sonia Lewycka, Alex Broom, Raph L. Hamers   +36 more
wiley   +1 more source

Overview of Antibiotic Use and Resistance: Setting the Stage for Tigecycline [PDF]

Clinical Infectious Diseases, 2005
Since the introduction of antibiotics 6 decades ago, clinicians have taken comfort in the relative safety and exceptional efficacy of these drugs. Patients initially looked on antibiotics as “wonder drugs,” primarily because of their life-saving benefits in treating serious wounds, postsurgical infections, pneumonia, meningitis, endocarditis, and ...
openaire   +2 more sources

Accumulation of Histidine Reduce the Susceptibility of Vibrio splendidus Persister Cells to Tetracycline

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Histidine accumulation promotes tetracycline‐induced persister formation in V. splendidus. It enhances membrane potential and upregulating the efflux pump gene, thereby reducing antibiotic susceptibility. ABSTRACT Vibrio splendidus is an opportunistic pathogen widely distributed in marine environments, animal tissues and seabed sediments. It can infect
Yanan Li, Xinnan Pan, Jiayao Chen, Hong Ding, Yina Shao   +4 more
wiley   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Clinicopathological Features and Postoperative Complication Management of a Postauricular Granular Cell Tumor: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Postauricular granular cell tumors mimic parotid malignancies. Their resection disrupts fragile local microcirculation due to inherently thin skin and limited subcutaneous buffer, triggering ischemic necrosis and MRSE infection. Clinicians must prioritize functional tissue preservation and vigilant wound care to prevent these severe ...
Haotong Yuan, Chunhong Wang, Luran Wang, Dongxu Liu, Li Gao   +4 more
wiley   +1 more source

In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo . We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae
Spanu, Ta, De Angelis, Gb, Cipriani, Mb, Pedruzzi, Bb, D'Inzeo, Ta, Cataldo, MAbd, Sganga, Gc, Tacconelli, Eb   +15 more
openaire   +4 more sources

Antibiotic Resistance Profile of Wound Infection Isolates: High Resistance to Cephalosporins and Penicillin Among Ghanaian Patients in a Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim Antibiotics remain among the most frequently prescribed medications in clinical practice. However, antimicrobial resistance (AMR) is an inevitable and irreversible consequence of bacterial adaptation to antimicrobial exposure.
Nelson Kwashie, Samuel Antwi‐Baffour, Lawrence Annison, Lydia Ofosua Appah, Uwakmfon Paul, Solomon Akpobi, Ebenezer Senu   +6 more
wiley   +1 more source