Results 81 to 90 of about 5,707,439 (181)

Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae

Revista da Sociedade Brasileira de Medicina Tropical, 2016
: INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years.
Yin Yuhan, Yue Ziyun, Zhang Yongbo, Li Fuqiang, Zhang Qinghua   +4 more
doaj   +1 more source

First emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese hospital. [PDF]

PLoS ONE, 2014
Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013,
Xue Zhong, Hongtao Xu, Dongke Chen, Haijian Zhou, Xin Hu, Gang Cheng   +5 more
doaj   +1 more source

Overview of Antibiotic Use and Resistance: Setting the Stage for Tigecycline [PDF]

Clinical Infectious Diseases, 2005
Since the introduction of antibiotics 6 decades ago, clinicians have taken comfort in the relative safety and exceptional efficacy of these drugs. Patients initially looked on antibiotics as “wonder drugs,” primarily because of their life-saving benefits in treating serious wounds, postsurgical infections, pneumonia, meningitis, endocarditis, and ...
openaire   +2 more sources

Effect of Green‐Synthesized Silver Nanoparticles From Nepeta pogonosperma and Astrodaucus persicus on the Reduction of Bap Gene Expression in Strong Biofilm‐Producing Acinetobacter baumannii Clinical Isolates

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Green‐synthesized silver nanoparticles from Nepeta pogonosperma and Astrodaucus persicus significantly inhibit biofilm formation and downregulate bap gene expression in multidrug‐resistant clinical isolates of Acinetobacter baumannii. This eco‐friendly approach offers a promising strategy to combat antimicrobial resistance.
Maedeh Kakavan, Mehrdad Gholami, Mohammad Ahanjan, Mohammad Ali Ebrahimzadeh, Abolfazl Hossein Nataj, Tahoora Mousavi, Hamid Reza Goli   +6 more
wiley   +1 more source

Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens

Cell Reports
Summary: Tigecycline is a last-resort antibiotic primarily used to treat severe infections caused by multidrug-resistant (MDR) bacteria. However, the emergence of constantly appearing resistance determinants has drastically compromised its clinical ...
Feiyu Yu, Shuyao Zhu, Qingyang Lv, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
doaj   +1 more source

Study on MICs of Tigecycline in Clinical Isolates of Carbapenem Resistant Enterobacteriaceae (CRE) at a Tertiary Care Centre in North India [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Members of family Enterobacteriaceae are the most common Gram-negative bacteria isolated from clinical samples. Those Enterobacteriaceae which have acquired resistance to all β-lactams antibiotics including the carbapenems are ...
Vineeta Khare, Prashant Gupta, Fareya Haider, Rehana Begum   +3 more
doaj   +1 more source

Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram‐Negative Bacterial Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The ethanolic leaf extract of Mouriri elliptica exhibited antibacterial and antibiofilm activities against multidrug‐resistant clinical isolates and enhanced the activity of ampicillin. Its diverse chemical profile and low acute toxicity support this Cerrado species as a promising source of natural antibacterial adjuvants. ABSTRACT Bacterial resistance
Talita Vilalva Freire, Ana Carolina de Freitas Marques, Valéria dos Santos Gonçalves, Iluska Senna Bonfá Moslaves, Mônica Cristina Toffoli‐Kadri, Arthur Feliciano Camargo da Silva, Martha Janete Giz, Patrícia de Oliveira Figueiredo, Ana Camila Micheletti, Nídia Cristiane Yoshida   +9 more
wiley   +1 more source

Emergence of plasmid-mediated tigecycline resistance gene, tet(X4), in Escherichia fergusonii from pigs.

Journal of Global Antimicrobial Resistance, 2022
OBJECTIVES This study aimed to identify tigecycline-resistant tet(X4)-bearing Escherichia fergusonii isolated from pigs in China with a complete genome sequence. METHODS E.
Chunjiu Guan, Biao Tang, Hua Yang, Jian-Jia Ma, Yuting Huang, Canying Liu   +5 more
semanticscholar   +1 more source

Antibiotic Resistance and Biofilm‐Forming Capacity of Oral Biofilm Bacteria in Patients With Periodontitis and Healthy Individuals

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Key finding: Antimicrobial resistance was common across all groups and associated with biofilm‐forming capacity, an association that remains observational and species‐confounded. ABSTRACT This study aimed to analyse antimicrobial resistance (AMR) in bacterial isolates from subgingival biofilms of patients with periodontitis and supragingival biofilms ...
Nils Werner, Marie Schöffel, Annette Wittmer, Klaus Pelz, Kirstin Vach, Cornelia Frese, Christiane von Ohle, Diana Wolff, Fabian Cieplik, Ali Al‐Ahmad   +9 more
wiley   +1 more source

Mechanisms and phenotypic consequences of acquisition of tigecycline resistance by Stenotrophomonas maltophilia

, 2021
[Objectives]: To elucidate the potential mutation-driven mechanisms involved in the acquisition of tigecycline resistance by the opportunistic pathogen Stenotrophomonas maltophilia.
Martínez, José Luis, Blanco, Paula, Corona, Fernando   +2 more
core   +1 more source