Results 71 to 80 of about 30,783 (205)

Curvature and Microenvironment Regulation Enable Robust Seawater Electrochemical Hydrogen Peroxide Synthesis for On‐Site Marine Aquaculture

Interdisciplinary Materials, EarlyView.
This work designs pentagon‐defect‐enriched interconnected spherical carbon (PD/IS‐C) via curvature and microenvironment co‐engineering for seawater H2O2 electrosynthesis. Curvature modulates electronic structure to boost reactivity, while local alkaline microenvironment repels Cl− for enhanced stability, endowing PD/IS‐C with exceptional catalytic ...
Chang Zhang, Chunliang He, Huiyao Qi, Lilong Zhang, Hongshang Hu, Houfeng Zhang, Tonghui Zhao, Muneerah Alomar, Lipiao Bao, Huiying Yang, Jian Zhang, Xing Lu   +11 more
wiley   +1 more source

Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae

Emerging Microbes and Infections, 2020
Tigecycline is considered one of the last-resort antimicrobials for carbapenem-resistant K. pneumoniae. Plasmid-mediated tigecycline resistance remains largely unclear.
Shijun Sun, Hua Gao, Yudong Liu, Longyang Jin, Ruobing Wang, Xiaojuan Wang, Qi Wang, Yuyao Yin, Yawei Zhang, Hui Wang   +9 more
doaj   +1 more source

Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.

Microbiology Spectrum, 2021
Tigecycline is regarded as one of the few important last-resort antibiotics to treat complicated skin and intra-abdominal infections. Members of the genus Staphylococcus are zoonotic pathogens and pose a serious threat to public health.
Nannan Wang, Dexi Li, Stefan Schwarz, Shangshang Qin, Hong Yao, Xiang-Dang Du   +5 more
doaj   +1 more source

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

, 2012
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto, Carlotti, Chen, Chopra, De Luigi, Doershuk, Duivenvoorden, Dutta, Lambs, McNamara, Nelson, Nelson, Silvia, Stetler-Steveson, Tang, Thong, Wainwright, Yrjanheikki   +17 more
core   +2 more sources

Combination of Lenvatinib and Antibiotics: A Potential Approach to Enhance Sensitivity in Differentiated Thyroid Cancer

International Journal of Cancer, EarlyView.
Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger, Petra Huber‐Cantonati, Daniela D. Weber, Sarah Pichler, Georg Schischkow, Marta Garcia‐Miralles, Christian Pirich, Gundula Rendl, Teresa Kiener, Thomas Felder, Martin Geroldinger, Robert Terkola, Barbara Kofler, Johanna Pachmayr   +13 more
wiley   +1 more source

Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Of 26 tigecycline-nonsusceptible Klebsiella pneumonia e (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR ).
Zi-Ke, Sheng, Fupin, Hu, Weixia, Wang, Qinglan, Guo, Zhijun, Chen, Xiaogang, Xu, Demei, Zhu, Minggui, Wang   +7 more
openaire   +2 more sources

Molecular epidemiology and mechanisms of tigecycline resistance in carbapenem‐resistant Klebsiella pneumoniae isolates [PDF]

Journal of Clinical Laboratory Analysis, 2020
AbstractBackgroundThe emergence and transmission of tigecycline‐ and carbapenem‐resistant Klebsiella pneumoniae (TCRKP) have become a major concern to public health globally. Here, we investigated the molecular epidemiology and mechanisms of tigecycline resistance in carbapenem‐resistant K pneumoniae (CRKP) isolates.MethodsForty‐five non‐duplicate CRKP
Yumi Park, Qute Choi, Gye Cheol Kwon, Sun Hoe Koo   +3 more
openaire   +2 more sources

Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae

Revista da Sociedade Brasileira de Medicina Tropical, 2016
: INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years.
Yin Yuhan, Yue Ziyun, Zhang Yongbo, Li Fuqiang, Zhang Qinghua   +4 more
doaj   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens

Cell Reports
Summary: Tigecycline is a last-resort antibiotic primarily used to treat severe infections caused by multidrug-resistant (MDR) bacteria. However, the emergence of constantly appearing resistance determinants has drastically compromised its clinical ...
Feiyu Yu, Shuyao Zhu, Qingyang Lv, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
doaj   +1 more source