Results 71 to 80 of about 5,707,439 (181)

Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.

open access: yesMicrobiology Spectrum, 2021
Tigecycline is regarded as one of the few important last-resort antibiotics to treat complicated skin and intra-abdominal infections. Members of the genus Staphylococcus are zoonotic pathogens and pose a serious threat to public health.
Nannan Wang   +5 more
doaj   +1 more source

In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii [PDF]

open access: yesJournal of Antimicrobial Chemotherapy, 2008
Sir, Acinetobacter baumannii has emerged as a leading nosocomial pathogen, particularly in intensive care units (ICUs), where several outbreaks have been described. Treatment of severe A. baumannii infection represents a difficult clinical challenge due to the propensity of this organism to acquire antimicrobial resistance, resulting in the emergence ...
A. CAPONE   +4 more
openaire   +4 more sources

Tigecycline combination therapy for fulminant Clostridioides difficile infection: an Australian experience

open access: yesInternal Medicine Journal, EarlyView.
Abstract Background Recent European Society of Clinical Microbiology and Infection and Australasian Society of Infectious Diseases Clostridioides difficile infection (CDI) management guidelines endorse the addition of intravenous tigecycline in patients who are progressing to fulminant infection.
Emma Bishop   +5 more
wiley   +1 more source

Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae

open access: yesEmerging Microbes and Infections, 2020
Tigecycline is considered one of the last-resort antimicrobials for carbapenem-resistant K. pneumoniae. Plasmid-mediated tigecycline resistance remains largely unclear.
Shijun Sun   +9 more
doaj   +1 more source

Convergence of plasmid-mediated Colistin and Tigecycline resistance in Klebsiella pneumoniae

open access: yesFrontiers in Microbiology
Objective The co-occurrence of colistin and tigecycline resistance genes in Klebsiella pneumoniae poses a serious public health problem. This study aimed to characterize a K.
Yujie Zhao   +6 more
semanticscholar   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

open access: yesPeriodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez   +6 more
wiley   +1 more source

Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

open access: yesMedicine Science, 2017
Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms.
Yucel Duman   +2 more
doaj   +1 more source

Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage

open access: yesFrontiers in Microbiology, 2023
IntroductionThe tigecycline-resistant Enterobacterales have emerged as a great public concern, and the mobile tet(X) variants and tmexCD-toprJ efflux pump are mainly responsible for the spread of tigecycline resistance.
Ying Li   +5 more
doaj   +1 more source

Combination of Lenvatinib and Antibiotics: A Potential Approach to Enhance Sensitivity in Differentiated Thyroid Cancer

open access: yesInternational Journal of Cancer, Volume 159, Issue 8, Page 1974-1989, 15 October 2026.
Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger   +13 more
wiley   +1 more source

The contribution of rsha mutations and efflux pumps in tigecycline resistance in abscessus [PDF]

open access: yes, 2022
Tigecycline is an important antibiotic in treating patients with Mycobacteroides abscessus infections. Tigecycline resistance was previously associated with dysregulated stress response induced by the abnormal interaction between the SigH and RshA ...
Aw, Kar Men
core  

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