Results 41 to 50 of about 5,707,439 (181)

Emergence of novel tigecycline resistance gene tet(X5) variant in multidrug-resistant Acinetobacter indicus of swine farming environments.

Veterinary Microbiology, 2023
Antibiotic-resistant bacteria are emerging all the time, but the continued emergence of novel resistance genes and genetic structures is even more alarming. Tigecycline is currently the important last barrier in the treatment of multidrug-resistant (MDR)
Yumeng Cheng, Yakun Li, Meng Yang, Yang He, Xinru Shi, Zhidan Zhang, Yesheng Zhong, Yuan Zhang, Hongbin Si   +8 more
semanticscholar   +1 more source

Mobile Tigecycline Resistance: An Emerging Health Catastrophe Requiring Urgent One Health Global Intervention

Frontiers in Microbiology, 2022
Mobile tigecycline resistance (MTR) threatens the clinical efficacy of the salvage antibiotic, tigecycline (TIG) used in treating deadly infections in humans caused by superbugs (multidrug-, extensively drug-, and pandrug-resistant bacteria), including ...
Madubuike Umunna Anyanwu, O. Nwobi, C. Okpala, I. Ezeonu   +3 more
semanticscholar   +1 more source

Identification of Novel tet(X3) Variants Resistant To Tigecycline in Acinetobacter Species

Microbiology Spectrum, 2022
The emergence of the tet(X) gene is a severe challenge to global public health security, as clinical tigecycline resistance shows a rapidly rising trend. In this research, we identified two tigecycline-resistant Acinetobacter sp. strains containing seven
Yumeng Cheng, Yakun Li, Runhao Yu, Mingxiang Ma, Meng Yang, Hongbin Si   +5 more
doaj   +1 more source

1456. Resistance Mechanisms of Tigecycline in Enterococcus faecalis [PDF]

Open Forum Infectious Diseases, 2020
Abstract Background Enterococcus faecalis have been regarded as one of the leading causes of the nosocomial infections worldwide. Tigecycline (TGC) is considered as a choice of last resort for the treatment of infections caused by multidrug-resistant E.
Bai, Bing, Wen, Zewen, Lin, Zhiwei, H, Tam Vincent, Yu, Zhijian   +4 more
openaire   +1 more source

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe Towards a common nomenclature [PDF]

, 2018
International audienceVancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail.
Peixe, Luísa, del Grosso, Maria, Coque, Teresa M, Bender, Jennifer K., Pantosti, Annalisa, Novais, Carla, Schaffer, Kirsten, Hegstad, Kristin, Murchan, Stephen, Freitas, Ana R, Werner, Guido, Hammerum, Anette M., Coque, Teresa M., Sadowy, Eva, Sadowy, Ewa, Bender, Jennifer K, Cattoir, Vincent, Freitas, Ana R., Westh, Henrik, Hammerum, Anette M, Burns, Karen, Bender, Jennifer   +21 more
core   +1 more source

Presence of Mobile Tigecycline Resistance Gene tet(X4) in Clinical Klebsiella pneumoniae

Microbiology spectrum, 2022
Tigecycline, the first member of glycylcycline class antibiotic, is often considered one of the effective antibiotics against multidrug-resistant (MDR) infections.
W. Zhai, Y. Tian, Mi-Yu Lu, Muchen Zhang, Huangwei Song, Yulin Fu, Tengfei Ma, Chengtao Sun, L. Bai, Yang Wang, Dejun Liu, Ying Zhang   +11 more
semanticscholar   +1 more source

Change of Hypermucoviscosity in the Development of Tigecycline Resistance in Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strains

, 2020
In this study, we developed tigecycline resistance in Klebsiella pneumoniae ST23 strains in vitro and investigated the change in virulence associated with hypermucoviscosity. In vitro-induced tigecycline-resistant (TGC-IR) K.
Dongwoo Shin, Kwan Soo Ko, Haejeong Lee, Suyeon Park   +3 more
core   +1 more source

Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster tmexC2D2.2-toprJ2 Identified in Chromosome of Aeromonas spp.

Microbiology Spectrum, 2022
The appearance and prevalence of novel plasmid-encoded tigecycline resistance efflux pump gene clusters tmexC1D1-toprJ1 and tmexC2D2-toprJ2 in Enterobacteriaceae have raised a threat to public health.
Cheng-Zhen Wang, Xun Gao, Jie-Ying Tu, Lu-Chao Lv, Wen-Xian Pu, Xiao-Tong He, Yan-Xiang Jiao, Yu-Ting Deng, Jian-Hua Liu   +8 more
doaj   +1 more source

Once-a-week tigecycline for the treatment of drug-resistant TB [PDF]

Journal of Antimicrobial Chemotherapy, 2019
MDR-TB and XDR-TB have poor outcomes.To examine the efficacy of tigecycline monotherapy in the hollow fibre system model of TB.We performed pharmacokinetic/pharmacodynamic studies using tigecycline human-like concentration-time profiles in the hollow fibre system model of TB in five separate experiments using Mycobacterium tuberculosis in log-phase ...
Devyani Deshpande, Gesham Magombedze, Shashikant Srivastava, Paula Bendet, Pooi S Lee, Kayle N Cirrincione, Katherine R Martin, Keertan Dheda, Tawanda Gumbo   +8 more
openaire   +2 more sources

Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin. [PDF]

, 2014
A yearlong study was performed to examine the effect of antibiotic administration on the bacterial gut flora. Gram-negative facultative anaerobic bacteria were recovered from the feces of healthy adult volunteers administered amoxicillin, minocycline or ...
Theresa eHunt, Javier eNunez-Garica, Miranda eKirchner, Miranda Kirchner, Yanmin Hu, Weile, J, Anthony Coates, Javier Nunez-Garcia, Card, R, Anjum, MF, Theresa Hunt, Roderick Card, Jan Weile, Kirchner, M, Mafura, M, Muriel eMafura, Hunt, T, Abu-Oun, M, Muna eAnjum, Roderick eCard, Muriel Mafura, Manal eAbuoun, Muna F. Anjum, Hu, Y, Nunez-Garcia, J, Yanmin eHu, Manal Abu-Oun, Jan eWeile, Anthony eCoates, Coates, A   +29 more
core   +1 more source