Results 21 to 30 of about 26,995 (192)

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

open access: yesJournal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +1 more source

Proteomics Study of the Synergistic Killing of Tigecycline in Combination With Aminoglycosides Against Carbapenem-Resistant Klebsiella pneumoniae

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Co-administration of antibiotics with synergistic effects is one method to combat carbapenem-resistant organisms. Although the synergistic effects of tigecycline combined with aminoglycosides against carbapenem-resistant Klebsiella pneumoniae (CRKP) have
Xinqian Ma   +7 more
doaj   +1 more source

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus

open access: yesMicrobiology Spectrum, 2023
Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years.
Honghao Huang   +6 more
doaj   +1 more source

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf

open access: yesEmerging Microbes and Infections, 2021
Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua   +12 more
doaj   +1 more source

In-vitro activity of tigecycline and comparator agents against common pathogens: Indian experience

open access: yesJournal of Infection in Developing Countries, 2019
Introduction: Tigecycline Evaluation and Surveillance Trail (TEST) study is an on-going global surveillance. The study was performed to determine the susceptibility of common pathogens to tigecycline and comparator antibiotics by broth microdilution ...
Balaji Veeraraghavan   +8 more
doaj   +1 more source

Effect of ramR loss-of-function insertion on tigecycline resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

open access: yesJournal of Global Antimicrobial Resistance, 2020
Objectives: Tigecycline is an antibacterial agent restricted for use against carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to identify the tigecycline resistance mechanism in clinical CRKP isolates obtained from a 60-year-old ...
Yihan Mao   +4 more
doaj   +1 more source

Characterization of Tigecycline-Heteroresistant Klebsiella pneumoniae Clinical Isolates From a Chinese Tertiary Care Teaching Hospital

open access: yesFrontiers in Microbiology, 2021
Tigecycline has been used as one of the therapeutic choices for the treatment of infections caused by multidrug-resistant Klebsiella pneumoniae. However, the emergence of tigecycline heteroresistance has led to great challenges in treating these ...
Qiaoyu Zhang   +3 more
doaj   +1 more source

Induction of Tigecycline Resistance in Acinetobacter baumannii

open access: yesBio-Protocol, 2014
Multidrug resistance Acinetobacter baumannii (A. baumannii) (MDRAB) has emerged as a serious threat in hospitals in recent years. Currently, there are few antibiotics, including tigecycline, available to treat infections caused by MDRAB effectively. Both
Ming-Feng Lin, Yun-You Lin, Chung-Yu Lan
doaj   +1 more source

Prevalence and risk factors of tigecycline-induced liver injury: A multicenter retrospective study

open access: yesInternational Journal of Infectious Diseases, 2022
: Objective: We conducted this multicenter retrospective study to evaluate the prevalence, clinical patterns, and risk factors for tigecycline-induced liver injury, which is a type of drug-induced liver injury (DILI).
Zhenwei Yu   +5 more
doaj   +1 more source

Tigecycline Interferes with Fibrinogen Polymerization Independent of Peripheral Interactions with the Coagulation System

open access: yesAntibiotics, 2020
Tigecycline offers broad anti-bacterial coverage for critically ill patients with complicated infections. A described but less researched side effect is coagulopathy.
Anna Brandtner   +9 more
doaj   +1 more source

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