Results 21 to 30 of about 28,714 (188)

Comparison of bleeding risk and hypofibrinogenemia-associated risk factors between tigecycline with cefoperazone/sulbactam therapy and other tigecycline-based combination therapies

Frontiers in Pharmacology, 2023
Background: Tigecycline and cefoperazone/sulbactam can cause coagulation disorders; tigecycline may also lead to hypofibrinogenemia, raising safety concerns.
Lei Zhang, Xinfeng Cai, Fangchen Peng, Shuangshuang Tian, Xinjing Wu, Yun Li, Jinlin Guo   +6 more
doaj   +1 more source

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Journal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +1 more source

Tigecycline

Reactions Weekly, 2012
Hoofnagle JH.
europepmc   +2 more sources

Proteomics Study of the Synergistic Killing of Tigecycline in Combination With Aminoglycosides Against Carbapenem-Resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2022
Co-administration of antibiotics with synergistic effects is one method to combat carbapenem-resistant organisms. Although the synergistic effects of tigecycline combined with aminoglycosides against carbapenem-resistant Klebsiella pneumoniae (CRKP) have
Xinqian Ma, Shining Fu, Yifan Wang, Lili Zhao, Wenyi Yu, Yukun He, Wentao Ni, Zhancheng Gao   +7 more
doaj   +1 more source

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus

Microbiology Spectrum, 2023
Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years.
Honghao Huang, Peng Wan, Xinyue Luo, Yixing Lu, Xiaoshen Li, Wenguang Xiong, Zhenling Zeng   +6 more
doaj   +1 more source

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf

Emerging Microbes and Infections, 2021
Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua, Jintao He, Jingfen Wang, Linghong Zhang, Linyue Zhang, Qingye Xu, Keren Shi, Sebastian Leptihn, Yue Shi, Xiaoting Fu, Pengfei Zhu, Paul G. Higgins, Yunsong Yu   +12 more
doaj   +1 more source

A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2022
The increasing incidence of tigecycline resistance undoubtedly constitutes a serious threat to global public health. The combination therapies had become the indispensable strategy against this threat. Herein, 11 clinical tigecycline-resistant Klebsiella
Lilan Sun, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang, Xuefu You   +7 more
doaj   +1 more source

In-vitro activity of tigecycline and comparator agents against common pathogens: Indian experience

Journal of Infection in Developing Countries, 2019
Introduction: Tigecycline Evaluation and Surveillance Trail (TEST) study is an on-going global surveillance. The study was performed to determine the susceptibility of common pathogens to tigecycline and comparator antibiotics by broth microdilution ...
Balaji Veeraraghavan, Aruna Poojary, Chaitra Shankar, Anurag Kumar Bari, Seema Kukreja, Bhuvaneswari Thukkaram, Ramya Gajaraj Neethimohan, Yamuna Devi Bakhtavachalam, Shweta Kamat   +8 more
doaj   +1 more source

Investigating the biological properties of tigecycline [PDF]

, 2012
Antibiotic resistance of many bacterial strains to current antibiotic treatment strategies are increasing. Bacterial biofilm related diseases displaying resistance to current antibiotics is an area of intense investigations. Failure to eradicate biofilm
Quinn, Ryan Francis
core   +7 more sources

Effect of ramR loss-of-function insertion on tigecycline resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2020
Objectives: Tigecycline is an antibacterial agent restricted for use against carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to identify the tigecycline resistance mechanism in clinical CRKP isolates obtained from a 60-year-old ...
Yihan Mao, Qiucheng Shi, Ping Zhang, Yan Jiang, Yunsong Yu   +4 more
doaj   +1 more source