Results 31 to 40 of about 1,785 (194)

Omadacycline treatment of severe Chlamydia psittaci pneumonia with septic shock diagnosed via metagenomic next-generation sequencing [PDF]

Journal of Infection in Developing Countries
Introduction: Parrot fever, caused by Chlamydia psittaci, is a zoonotic disease typically treated with tetracyclines. Omadacycline, a novel aminomethyl tetracycline, has limited reports on its efficacy in severe Chlamydia psittaci pneumonia in the ...
Ping Xu, Zhitong Huang
doaj   +2 more sources

Omadacycline for the Treatment of Severe Legionella Pneumonia Complicated with Multiple Organ Failure: A Case Report [PDF]

International Medical Case Reports Journal
Limin Xu,1 Ying Xiong,2 Changquan Fang2 1Department of Geriatrics, Huizhou First Hospital, Huizhou, Guangdong Province, Peoples’ Republic of China; 2Department of Pulmonary and Critical Care Medicine, Huizhou Central People’s Hospital, Huizhou, Guangdong
Xu L, Xiong Y, Fang C
doaj   +1 more source

Activity of omadacycline in vitro against Clostridioides difficile and preliminary efficacy assessment in a hamster model of C. difficile-associated diarrhoea

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Antibiotics are associated with increased risk of Clostridioides difficile infection, which has limited treatment options. We assessed in vitro activity of omadacycline (an aminomethylcycline antibiotic) against the C.
Raina Gay Leahy, Alisa W. Serio, Kelly Wright, Maria M. Traczewski, S. Ken Tanaka   +4 more
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Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium

Microbiology Spectrum, 2022
Here, we performed in vitro susceptibility testing on 10 Mycoplasma genitalium isolates against omadacycline, minocycline, tetracycline, doxycycline, moxifloxacin, levofloxacin, and azithromycin.
Ken B. Waites, Donna M. Crabb, T. Prescott Atkinson, William M. Geisler, Li Xiao   +4 more
doaj   +1 more source

Intravenous Versus Oral Omadacycline or Linezolid for Acute Bacterial Skin and Skin Infections: A post hoc Analysis of the OASIS Trials [PDF]

Infectious Diseases and Therapy
Introduction Appropriate oral antibiotic therapy for the treatment of acute bacterial skin and skin structure infections (ABSSSI) is a challenge, as current oral treatment guidelines do not fully cover the most common skin pathogens.
George D. Rodriguez, Nathan Warren, Roman Yashayev, Surya Chitra, Maria Amodio-Groton, Kelly Wright   +5 more
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Omadacycline for treatment of acute bacterial infections: a meta-analysis of phase II/III trials

BMC Infectious Diseases, 2023
Objective This study aims to assess the clinical efficacy and safety of omadacycline for the treatment of acute bacterial infections. Methods A search of PubMed, Embase, Cochrane Library, and Clinical Trials was conducted up to July 1, 2022.
Fei Lin, Rong He, Bin Yu, Bowen Deng, Baodong Ling, Mingyong Yuan   +5 more
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Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects

Frontiers in Pharmacology, 2022
Objective: Omadacycline is a new type of aminomethylcycline antibiotic, having a broad antibacterial spectrum. But the pharmacokinetic characteristics and safety profile of the Chinese population remain unknown. It is also unclear whether the US-approved
Haijing Yang, Haijing Yang, Haijing Yang, Zhiwei Huang, Zhiwei Huang, Zhiwei Huang, Yuancheng Chen, Yuancheng Chen, Yuancheng Chen, Yusong Zhu, Guoying Cao, Guoying Cao, Guoying Cao, Jingjing Wang, Jingjing Wang, Jingjing Wang, Yan Guo, Yan Guo, Yan Guo, Jicheng Yu, Jicheng Yu, Jicheng Yu, Jufang Wu, Jufang Wu, Jufang Wu, Lichuan Liu, Jun Deng, Jing Liu, Harald Reinhart, Jing Zhang, Jing Zhang, Jing Zhang, Xiaojie Wu, Xiaojie Wu, Xiaojie Wu   +34 more
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In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden

Microbiology Spectrum, 2021
Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects.
Angela Camporeale, Chaitanya Tellapragada, Jelena Kornijenko, Carl Erik Nord, Christian G. Giske   +4 more
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In vitro antimicrobial activity and resistance mechanisms of the new generation tetracycline agents, eravacycline, omadacycline, and tigecycline against clinical Staphylococcus aureus isolates

Frontiers in Microbiology, 2022
In this study, we investigated the in vitro activity and resistance mechanisms of the new generation tetracycline agents, namely eravacycline, omadacycline, and tigecycline, against Staphylococcus aureus isolates. A total of 1,017 non-duplicate S. aureus
Weiliang Zeng, Xiaotuan Zhang, Yan Liu, Yi Zhang, Mengxin Xu, Sipei Wang, Yao Sun, Tieli Zhou, Lijiang Chen   +8 more
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Investigating the immunomodulatory activities of omadacycline

Journal of Antimicrobial Chemotherapy, 2022
Abstract Background Apart from their antimicrobial activities, some antibiotics have immunomodulatory effects on host cells, particularly monocytes. Because hyperactivation of the pro-inflammatory cytokine response contributes to acute lung injury in patients with bacterial pneumonia and other lung ...
Bryant, Amy E, Stevens, Dennis L
openaire   +2 more sources