Results 1 to 10 of about 42,760 (246)

Bidirectional Interaction between Tetracyclines and Gut Microbiome

Antibiotics, 2023
The escalating misuse of antibiotics, particularly broad-spectrum antibiotics, has emerged as a pivotal driver of drug resistance. Among these agents, tetracyclines are widely prescribed for bacterial infections, but their indiscriminate use can ...
Jerzy Jaroszewski, Krzysztof Czaja, Niles Mamun   +2 more
exaly   +4 more sources

Evidence that SmTetX is not a tetracycline resistance determinant [PDF]

Microbiology Spectrum
SmTetX, a flavin-dependent monooxygenase from the opportunistic pathogen Stenotrophomonas maltophilia, is structurally related to the tetracycline-degrading Tet(X) resistance enzymes, though displays substantial divergence in active site residues.
Matthew J. Beech, Maria M. Trush, Edmond C. Toma, Alistair J. M. Farley, Timothy R. Walsh, Christopher J. Schofield   +5 more
doaj   +2 more sources

A Comparative Multi-Bioassay Assessment of Tetracycline Mixture Toxicity in Water and Soil Using Harmonized Dose–Response Modeling [PDF]

Journal of Xenobiotics
Tetracyclines (TCs) are antibiotics widely used in human and veterinary medicine as well as in agricultural practices. They may be retained in soil or drift into freshwater, thereby exerting effects on non-target organisms and deteriorating ecological ...
Chrysi A. Papadimitriou, Christina Emmanouil, Amalia Moriki, Vasileios Bartzis   +3 more
doaj   +2 more sources

Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity

Viruses, 2021
The rapid spread of the pandemic caused by the SARS-CoV-2 virus has created an unusual situation, with rapid searches for compounds to interfere with the biological processes exploited by the virus.
Luisa Diomede, Sara Baroni, Ada De Luigi, Arianna Piotti, Jacopo Lucchetti, Claudia Fracasso, Luca Russo, Valerio Bonaldo, Nicolò Panini, Federica Filippini, Fabio Fiordaliso, Alessandro Corbelli, Marten Beeg, Massimo Pizzato, Francesca Caccuri, Marco Gobbi, Emiliano Biasini, Arnaldo Caruso, Mario Salmona   +18 more
doaj   +1 more source

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

mBio, 2022
Acinetobacter baumannii causes high mortality in ventilator-associated pneumonia patients, and antibiotic treatment is compromised by multidrug-resistant strains resistant to β-lactams, carbapenems, cephalosporins, polymyxins, and tetracyclines.
David M. P. De Oliveira, Brian M. Forde, Minh-Duy Phan, Bernhard Steiner, Bing Zhang, Johannes Zuegg, Ibrahim M. El-deeb, Gen Li, Nadia Keller, Stephan Brouwer, Nichaela Harbison-Price, Amanda J. Cork, Michelle J. Bauer, Saleh F. Alquethamy, Scott A. Beatson, Jason A. Roberts, David L. Paterson, Alastair G. McEwan, Mark A. T. Blaskovich, Mark A. Schembri, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker   +22 more
doaj   +1 more source

Fate of Sulfonamides and Tetracyclines in Meat during Pan Cooking: Focus on the Thermodegradation of Sulfamethoxazole

Molecules, 2022
Although antimicrobials are generally found in trace amounts in meat, the human health risk they bear cannot be ignored. With the ultimate aim of making a better assessment of consumer exposure, this study explored the effects of pan cooking on ...
Christelle Planche, Sylvie Chevolleau, Maria-Hélèna Noguer-Meireles, Isabelle Jouanin, Sophie Mompelat, Jérémy Ratel, Eric Verdon, Erwan Engel, Laurent Debrauwer   +8 more
doaj   +1 more source

Efflux Might Participate in Decreased Susceptibility to Oxytetracycline in Contagious Agalactia-Causative Mycoplasma spp.

Animals, 2021
Contagious agalactia is associated with mastitis, keratoconjunctivitis, arthritis, pneumonia, and septicemia in small ruminants in countries with large dairy industries worldwide.
Juan Tatay-Dualde, Miranda Prats-van der Ham, Patrice Gaurivaud, Christian de la Fe, Florence Tardy   +4 more
doaj   +1 more source

The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs

Biomolecules, 2021
Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs ...
Hassan Sarker, Ayman Haimour, Ravneet Toor, Carlos Fernandez-Patron   +3 more
doaj   +1 more source

Manure Compost Is a Potential Source of Tetracycline-Resistant Escherichia coli and Tetracycline Resistance Genes in Japanese Farms

Antibiotics, 2020
Manure compost has been thought of as a potential important route of transmission of antimicrobial-resistant bacteria (ARB) and antimicrobial resistance genes (ARGs) from livestock to humans.
Nobuki Yoshizawa, Masaru Usui, Akira Fukuda, Tetsuo Asai, Hidetoshi Higuchi, Eiryu Okamoto, Kanako Seki, Hideshige Takada, Yutaka Tamura   +8 more
doaj   +1 more source

Distribution of ermB, ermF, tet(W), and tet(M) Resistance Genes in the Vaginal Ecosystem of Women during Pregnancy and Puerperium

Pathogens, 2021
The inhabitants of the vaginal ecosystem can harbor genetic determinants conferring antimicrobial resistance. However, detailed data about the distribution of resistance genes in the vaginal microbiome of pregnant women are still lacking.
Marco Severgnini, Tania Camboni, Camilla Ceccarani, Sara Morselli, Alessia Cantiani, Sara Zagonari, Giulia Patuelli, Maria Federica Pedna, Vittorio Sambri, Claudio Foschi, Clarissa Consolandi, Antonella Marangoni   +11 more
doaj   +1 more source