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Fluoroquinolones in the treatment of meningitis
Current Infectious Disease Reports, 2003 The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standard therapeutic regimens. Due to their excellent activity in vitro and their good penetration into the cerebrospinal fluid (CSF), fluoroquinolones appear promising for the treatment of meningitis caused by gram-negative microorganisms, ie, Neisseria ...
Philippe, Cottagnoud, Martin G., Täuber
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, 2016 Fluoroquinolone antibiotics are frequently used in a variety of indications in hospital and outpatient settings due to the availability of oral dosage form.
Dimond, R (15809969) +2 more
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Cardiotoxicity of fluoroquinolones [PDF]
Journal of Antimicrobial Chemotherapy, 2002 Currently marketed fluoroquinolones enjoy an admirable safety profile that is not matched by any other antibiotic group. The widespread use of fluoroquinolones in the elderly, who are susceptible to cardiac arrhythmias because of underlying heart diseases, metabolic derangement and use of anti-arrhythmic agents and other medications that prolong the QT
Ethan, Rubinstein, John, Camm
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Revista Española de Quimioterapia, 2023 Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen
José Barberán +6 more
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Environmental contamination by fluoroquinolones [PDF]
, 2014 Over the past few decades, a high number of pharmaceuticals have been detected in surface, ground and drinking waters. This contamination comes from domestic sewage, livestock, hospitals and chemical-pharmaceutical industries.
Teixeira, Antonio Carlos Silva Costa +7 more
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A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis. [PDF]
, 2009 OBJECTIVES: To review evidence supporting use of fluoroquinolones as first line agents over other antibiotics for treating typhoid and paratyphoid fever (enteric fever). DESIGN: Meta-analysis of randomised controlled trials.
Thaver, D +11 more
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Pharmacodynamics of Fluoroquinolones [PDF]
Clinical Infectious Diseases, 1998 Fluoroquinolone antimicrobial agents are highly active against aerobic or facultative gram-negative bacilli. The fluoroquinolones have been shown to be very concentration dependent in their rates of killing and also have a postantibiotic effect against most gram-negative pathogens.
H, Lode, K, Borner, P, Koeppe
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Comparative Studies of Fluoroquinolones in the Treatment of Urinary Tract Infections [PDF]
, 1988 The results of comparative trials of fluoroquinolones for the treatment of uncomplicated and complicated urinary tract infections (UTI) were reviewed. Severalrandomized, comparative trials showedthat in uncomplicatedUTI norfloxacin, ciprofloxacin, and ...
Glauser, M. P. +4 more
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Fluoroquinolones and Anaerobes [PDF]
Clinical Infectious Diseases, 2006 The usefulness of fluoroquinolones for the treatment of mixed aerobic and anaerobic infections has been investigated since these agents started being used in clinical practice. Newer compounds have increased in vitro activity against anaerobes, but clinically relevant susceptibility breakpoints for these bacteria have not been established ...
Gary E, Stein, Ellie J C, Goldstein
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Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test [PDF]
, 2012 The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Viciafaba roots by direct contact exposure to a solid matrix.
Khadra, Ahmed +20 more
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