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Repositioning of Fluoroquinolones: A New Approach in Antitumor Therapy [PDF]
BiologyFluoroquinolones are known for their antibacterial properties, but recent research has revealed their potential to inhibit the growth and proliferation of cancer cells.
Jeferson Ricardo da Silva +4 more
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Fluoroquinolone Mannich bases as promising biologically beneficial molecules [PDF]
Minia Journal of Medical Research, 2021 Mannich bases, a structurally heterogeneous aminomethyl functionality, found numerous applicationsin medicinal chemistry field. Fluoroquinolones-Mannich bases here is discussed, with prominence onthe correlation between structure and biological activity ...
Mohamed Abdel-Aziz +3 more
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Heliyon, 2023 Background: Tuberculosis (TB) is an epidemic disease in Thailand. Fluoroquinolones are used to treat TB and have a lengthy treatment course. Therefore, many patients may have adverse effects from these medications.
Jirarat Chongboonwatana +2 more
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Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones [PDF]
Journal of Advanced Biomedical and Pharmaceutical Sciences, 2021 Fluoroquinolones are known widely used synthetic antibacterial agents. Generally, there were some obstacles associated with their therapeutic use.
Mohamed Samir +4 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Fluoroquinolones are first‐line antibiotics recommended for the treatment of complicated urinary tract infections (UTIs), with frequent reports of adverse effects of aortic aneurysm (AA) and aortic dissection (AD).
Yin‐Yang Chen +6 more
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Fluoroquinolones’ Biological Activities against Laboratory Microbes and Cancer Cell Lines
Molecules, 2022 Development of novel derivatives to rein in and fight bacteria have never been more demanding, as microbial resistance strains are alarmingly increasing.
Ghadeer A. R. Y. Suaifan +2 more
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Cardiotoxicity of fluoroquinolones [PDF]
Journal of Antimicrobial Chemotherapy, 2002 Currently marketed fluoroquinolones enjoy an admirable safety profile that is not matched by any other antibiotic group. The widespread use of fluoroquinolones in the elderly, who are susceptible to cardiac arrhythmias because of underlying heart diseases, metabolic derangement and use of anti-arrhythmic agents and other medications that prolong the QT
Ethan, Rubinstein, John, Camm
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Revista Española de Quimioterapia, 2023 Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen
José Barberán +6 more
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Frontiers in Veterinary Science, 2022 Mycoplasma bovis (M. bovis) is one of the important pathogens for yaks. Aminoglycosides and fluoroquinolones are frequently used medications for the treatment of M. bovis. Drug-resistant strains were inevitable with the abuse of antibiotics.
Jiaqiang Niu +5 more
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Transporter and metabolizer gene polymorphisms affect fluoroquinolone pharmacokinetic parameters
Frontiers in Pharmacology, 2022 Tuberculosis (TB) is an infectious disease that occurs globally. Treatment of TB has been hindered by problems with multidrug-resistant strains (MDR-TB). Fluoroquinolones are one of the main drugs used for the treatment of MDR-TB.
Nurul Annisa +5 more
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