Results 41 to 50 of about 66,971 (207)

The future of fluoroquinolones

Annals of Medicine, 2000
The mutant prevention concentration (MPC) is a new measure of antibiotic potency above which a microbe must attain two concurrent resistance mutations for growth. For some C-8-methoxy fluoroquinolone-pathogen combinations, the value of MPC is below human serum drug concentration achieved with standard doses.
openaire   +2 more sources

Risk of Severe Dysglycemia Among Diabetic Patients Receiving Levofloxacin, Ciprofloxacin, or Moxifloxacin in Taiwan

, 2014
Background. Observational studies and fatal case reports raise concern about the safety of severe dysglycemia associated with fluoroquinolone use. The objective of this study was to assess the risk of severe dysglycemia among diabetic patients who ...
賴美淑 ;張家勳, Chou, Hsu-Wen;Wang, Jiun-Ling;Chang, Chia-Hsuin;Lee, Jen-Jyh;Shau, Wen-Yi;Lai, Mei-Shu   +1 more
core   +1 more source

Assessment of Knowledge Regarding Safety Profile, Use, and Boxed Warnings of Fluoroquinolones Among Healthcare Professionals in Saudi Arabia: A Potential Implication for Drug Regulatory Authorities

Frontiers in Medicine, 2022
BackgroundDespite a series of “boxed warnings” (BWs) issued by the US Food and Drug Administration (FDA), fluoroquinolones (FQs) are among the most prescribed antibiotics across the world.
Tauqeer Hussain Mallhi, Abdullah Salah Alanazi, Abdullah Salah Alanazi, Yusra Habib Khan, Nasser Hadal Alotaibi, Muhammad Salman, Abdulaziz Ibrahim Alzarea, Salah-Ud-Din Khan, Nabil K. Alruwaili, Alaa Salah Alenazi, Ahmed D. Alatawi, Zafar Iqbal, Muhammad Hammad Butt, Muhammad Shahid Iqbal   +13 more
doaj   +1 more source

The Use of Systemic and Topical Fluoroquinolones

, 2011
Appropriate prescribing practices for fluoroquinolones are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children becomes better defined. Earlier
null null, John S. Bradley, Mary Anne Jackson   +2 more
core   +1 more source

Fluoroquinolonas Fluoroquinolones

Iatreia, 1990
<p class="MsoNormal"><span style="font-size: 10pt; font-family: Arial">En este artículo se resumen aspectos históricos, químicos y farmacocinéticos de las fluoroquinolonas así como su mecanismo de acción, su espectro antibacteriano, las ...
Jesualdo Fuentes
doaj  

Analyses of Adverse Drug Reactions to Fluoroquinolones in Spontaneous Reports Before and After the Referral and in Clinical Routine Cases

Drugs in R&D
Introduction In November 2018, the European Medicines Agency (EMA) restricted the use of fluoroquinolones (used by mouth, injections or inhalation) in the context of a referral due to long-lasting and potentially irreversible adverse drug reactions (ADRs)
Diana Dubrall, Julia Wicherski, Maike Below, Jan Görtzen-Patin, Matthias Schmid, Sven Zenker, Britta Haenisch, Bernhardt Sachs   +7 more
doaj   +1 more source

Protection against Lipopolysaccharide-Induced Death by Fluoroquinolones

, 2000
Because fluoroquinolones have an immunomodulatory effect on cytokine production by lipopolysaccharide (LPS)-treated human monocytes, we examined the effect of fluoroquinolones on the survival of mice injected with a lethal dose of LPS. Trovafloxacin (100
Teri R. Slifer, Yasuhiro Suzuki, Jack S. Remington, Anis A. Khan, Fausto G. Araujo   +4 more
core   +1 more source

The use of fluoroquinolones in the treatment of community-acquired pneumonia and their cardiotoxic effects [PDF]

Клиническая микробиология и антимикробная химиотерапия
Fluoroquinolones (FQ) are widely used in the treatment of community-acquired pneumonia (CAP) in certain cases specified in Russian clinical guidelines. However, FQ are known to have cardiotoxic effects. There have been reports on proarrhythmogenic effect
Gamayunov D.Yu., Kalyagin A.N., Orlova G.M., Balabina N.M., Sinkova G.M., Sinkov A.V.   +5 more
doaj   +1 more source

Les résistances bactériennes aux fluoroquinolones

, 2021
La survenue de résistances bactériennes est en constante augmentation. Il s'agit d'un problème majeur de santé publique. Cet ouvrage centré sur les fluoroquinolones a pour objectif de détailler les connaissances actuelles sur les résistances bactériennes
Delville, Alexia
core  

Cardiac toxicity of fluoroquinolones and bedaquiline

, 2019
The review analyzes data on the impact of fluoroquinolones and bedaquiline on the cardiac conduction system. The dependence of the cardiotoxic effect of fluoroquinolones on their influence on the potassium channels of cardiomyocytes is presented.
A. G. Sаmoylovа, G. N. Mozhokinа
core   +1 more source