The emergence of inactivation enzyme-encoding genes tet(X), blaEBR, and estT challenges the effectiveness of tetracyclines, β-lactams, and macrolides.
Chong Chen +5 more
doaj +1 more source
Pharmacological Treatment of Secondary Lymphedema
Lymphedema is a chronic disease that results in swelling and decreased function due to abnormal lymphatic fluid clearance and chronic inflammation. In Western countries, lymphedema most commonly develops following an iatrogenic injury to the lymphatic ...
Stav Brown +8 more
doaj +1 more source
In general antibiotics interact cooperatively with host defences, weakening and decreasing the virulence of microbial pathogens, thereby increasing vulnerability to phagocytosis and eradication by the intrinsic antimicrobial systems of the host ...
Ronald Anderson +4 more
doaj +1 more source
High Yield Synthesis and Application of Magnetite Nanoparticles (Fe3O4)
Magnetite nanoparticles (Fe3O4), average particle size of 12.9 nm, were synthesized de novo from ferrous and ferric iron salt solutions (total iron salt concentration of 3.8 mM) using steady-state headspace NH3(g), 3.3% v/v, at room temperature and ...
Charles Wroblewski +4 more
doaj +1 more source
Doxycycline for the treatment of breast cancer-related lymphedema
Purpose: Secondary lymphedema is a common complication of cancer treatment for which no effective drug treatments yet exist. Level I clinical data suggests that doxycycline is effective for treating filariasis-induced lymphedema, in which it decreases ...
Stav Brown +5 more
doaj +1 more source
Determination of Pharmaceuticals in Coastal Systems Using Solid Phase Extraction (SPE) Followed by Ultra Performance Liquid Chromatography – tandem Mass Spectrometry (UPLC-MS/MS) [PDF]
This paper describes the optimization and validation of an analytical method for the determination of 83 pharmaceutically active compounds (PhACs) in aqueous samples using solid-phase extraction (SPE) followed by ultra performance liquid chromatography ...
Baena Nogueras, Rosa María +3 more
core +1 more source
Multiresistance of Bacteria to Veterinary Antibiotics in Dung and Manure Samples of Farm Animals [PDF]
Antibiotics are used in animal husbandry for treating and preventing diseases and as growth stimulators. Being disposed in the environment with dung and manure, they contribute to the spread of antibiotic-resistant bacteria and resistance genes.
N.V. Danilova +2 more
doaj
Seasonal variations in antibiotic resistance gene transport in the Almendares River, Havana, Cuba [PDF]
Numerous studies have quantified antibiotic resistance genes (ARG) in rivers and streams around the world, and significant relationships have been shown that relate different pollutant outputs and increased local ARG levels.
Charles W Knapp +6 more
core +2 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Bacterial resistance to antimicrobial agents and its impact on veterinary and human medicine [PDF]
Background Antimicrobial resistance has become a major challenge in veterinary medicine, particularly in the context of bacterial pathogens that play a role in both humans and animals.
Aarestrup +123 more
core +3 more sources

