Results 61 to 70 of about 1,472 (172)

In vitro activity and in vivo efficacy of omadacycline against Plasmodium species

Malaria Journal
Background Doxycycline is currently the only tetracycline-class antibiotic recommended for malaria prophylaxis. Omadacycline, a semisynthetic aminomethylcycline approved for treatment of adults with community-acquired bacterial pneumonia and acute ...
Michael S. Madejczyk, Susan E. Leed, Karl Kudyba, Alison Roth, Monica L. Martin, Patricia Lee, Diane Anastasiou, Jessica V. Pierce, Alisa W. Serio, Diana Caridha   +9 more
doaj   +1 more source

Dynamic distribution of systemically administered antibiotics in orthopeadically relevant target tissues and settings

APMIS, Volume 132, Issue 12, Page 992-1025, December 2024.
This review aimed to summarize the current literature on antibiotic distribution in orthopedically relevant tissues and settings where dynamic sampling methods have been used. PubMed and Embase databases were systematically searched. English‐published studies between 2004 and 2024 involving systemic antibiotic administration in orthopedically relevant ...
Maria Bech Damsgaard Nielsen, Andrea René Jørgensen, Maiken Stilling, Mads Kristian Duborg Mikkelsen, Nis Pedersen Jørgensen, Mats Bue   +5 more
wiley   +1 more source

Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system

Acta Pharmaceutica
This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between the second ...
Wang Zhu, Gan Guoping, Yao Haiping
doaj   +1 more source

A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii

Frontiers in Microbiology
BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAB)-caused severe pneumonia is associated with high mortality rates, and treatment options are limited.
Dayu Chen, Yechao Chen, Yechao Chen, Na Hu, Qiaoling Gu, Qiaoling Gu, Jingjing Kan, Jingjing Kan, Jinchun Liu, Haixia Zhang   +9 more
doaj   +1 more source

Efficacy and safety of vancomycin compared with those of alternative treatments for methicillin‐resistant Staphylococcus aureus infections: An umbrella review

Journal of Evidence-Based Medicine, Volume 17, Issue 4, Page 729-739, December 2024.
Abstract Objective To summarize the evidence on the efficacy and safety of vancomycin compared with those of alternative treatments in adult patients with methicillin‐resistant Staphylococcus aureus (MRSA) infection. Methods PubMed, Embase, and Web of Science were searched up to December 15, 2023, for systematic reviews and meta‐analyses comparing ...
Sujata Purja, Minji Kim, Yomna Elghanam, Hae Jung Shim, Eunyoung Kim   +4 more
wiley   +1 more source

Omadacycline: A Modernized Tetracycline

Clinical Infectious Diseases, 2019
AbstractWhen tetracyclines were introduced in the 1940s, these antibiotics offered a broad spectrum of activity against multiple types of pathogens. However, their utility waned after the selection of tetracycline resistance in the pathogens against which they were effective. Omadacycline is a semisynthetic aminomethylcycline antibacterial derived from
openaire   +1 more source

Management of vancomycin‐resistant Enterococci and daptomycin‐resistant Enterococci infections in liver transplant recipients in a single academic center

Transplant Infectious Disease, Volume 26, Issue 6, December 2024.
Vancomycin‐resistant Enterococci infections carry high mortality in liver transplant recipients, especially in the setting of daptomycin resistance. Infection relapsed or recurred in over 25% despite standard‐of‐care therapy. Source control is critical and more data is needed to establish an optimal treatment approach.
Aldo Barajas‐Ochoa, Olivia Hess, Tucker Smith, Matthew Ambrosio, Megan Morales, Idris Yakubu, Lora Thomas, David Bruno, Nicole Vissichelli   +8 more
wiley   +1 more source

Lip necrosis caused by methicillin‐resistant Staphylococcus aureus (MRSA)

JEADV Clinical Practice, Volume 3, Issue 4, Page 1253-1257, September 2024.
Abstract Labial necrosis is a rare condition with diverse causes, posing challenges for diagnosis and treatment. Methicillin‐resistant Staphylococcus aureus (MRSA) strains, particularly those positive for Panton‐Valentine leukocidin (PVL), further complicate management due to antibiotic resistance and heightened virulence.
Saad Khayat, Marc Agea Martínez, Manuel Tousidonis Rial, Alberto Diez Montiel, Santiago Ochandiano Caicoya   +4 more
wiley   +1 more source

Effect of Food on the Bioavailability of Omadacycline in Healthy Participants

The Journal of Clinical Pharmacology, 2016
AbstractOmadacycline is a first‐in‐class aminomethylcycline antibiotic being evaluated in phase 3 studies as oral and intravenous monotherapy for bacterial infections. This was a phase 1, randomized, open‐label, 4‐period, crossover study that evaluated the effect of food consumption on the bioavailability of omadacycline.
Tzanis, Evan, Manley, Amy, Villano, Stephen, Tanaka, S. Ken, Bai, Stephen, Loh, Evan   +5 more
openaire   +2 more sources

Antimicrobial consumption and resistance in bacteria from humans and food‐producing animals

EFSA Journal, Volume 22, Issue 2, February 2024.
Abstract The fourth joint inter‐agency report on integrated analysis of antimicrobial consumption (AMC) and the occurrence of antimicrobial resistance (AMR) in bacteria from humans and food‐producing animals (JIACRA) addressed data obtained by the Agencies' EU‐wide surveillance networks for 2019–2021.
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA), European Medicines Agency (EMA)   +2 more
wiley   +1 more source