Results 81 to 90 of about 2,144 (203)

Evaluation of the Impact of Comorbidities on Omadacycline Pharmacokinetics

Antimicrobial Agents and Chemotherapy, 2023
Omadacycline is approved in the United States for the treatment of patients with community-acquired bacterial pneumonia or acute bacterial skin and skin structure infections. Analyses were undertaken to evaluate pharmacokinetic differences among subjects or patients stratified by comorbidities.
M. Trang, E. A. Lakota, M. C. Safir, S. M. Bhavnani, L. Friedrich, J. N. Steenbergen, P. C. McGovern, E. Tzanis, C. M. Rubino   +8 more
openaire   +2 more sources

Unusual Presentation of Mycobacterium abscessus Thigh Mass: A Case Report

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Mycobacterium abscessus is a rapidly growing non‐tuberculous Mycobacterium (NTM) primarily associated with pulmonary infections, particularly in individuals with underlying lung conditions. While soft tissue infections are less common, their incidence has been increasing.
Ryan J. Blake, Grant R. McChesney, H. James Williams, Steven M. Holland, Allison M. Lastinger, Piyush Baindara   +5 more
wiley   +1 more source

In Vitro Activity of Omadacycline against Chlamydia pneumoniae [PDF]

, 2019
The activities of omadacycline, azithromycin, doxycycline, moxifloxacin, and levofloxacin were tested against 15 isolates of The minimum inhibitory concentration at which 90% of the isolates of were inhibited by omadacycline was 0.25 μg/ml (range, 0.03 ...
Hammerschlag, Margaret R, Huerta, Natalia, Kohlhoff, Stephan A   +2 more
core   +1 more source

Cochlear Implant Complicated by Nontuberculous Mycobacteria Infection: Report and Literature Review

Case Reports in Otolaryngology, Volume 2025, Issue 1, 2025.
Objective: Nontuberculosis mycobacteria (NTM) infection of cochlear implants are exceedingly rare. Here, we report one such case and review the literature surrounding previous reports. Methods: Case report. Case Report: A 76‐year‐old female underwent right cochlear implantation.
Haidee Chen, Erik B. Vanstrum, Rodell Santuray, Adam Xiao, Akira Ishiyama, M. Tayyar Kalcioglu   +5 more
wiley   +1 more source

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of ¹⁴ C-Omadacycline in Rats [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT The absorption, distribution, metabolism, and excretion (ADME) of omadacycline, a first-in-class aminomethylcycline antibiotic with a broad spectrum of activity against Gram-positive, Gram-negative, anaerobic, and atypical bacteria, were evaluated in rats.
Lin, Wen, Flarakos, Jimmy, Du, Yancy, Hu, Wenyu, He, Handan, Mangold, James, Tanaka, S. Ken, Villano, Stephen   +7 more
openaire   +2 more sources

Dynamic distribution of systemically administered antibiotics in orthopeadically relevant target tissues and settings

APMIS, Volume 132, Issue 12, Page 992-1025, December 2024.
This review aimed to summarize the current literature on antibiotic distribution in orthopedically relevant tissues and settings where dynamic sampling methods have been used. PubMed and Embase databases were systematically searched. English‐published studies between 2004 and 2024 involving systemic antibiotic administration in orthopedically relevant ...
Maria Bech Damsgaard Nielsen, Andrea René Jørgensen, Maiken Stilling, Mads Kristian Duborg Mikkelsen, Nis Pedersen Jørgensen, Mats Bue   +5 more
wiley   +1 more source

Efficacy and safety of vancomycin compared with those of alternative treatments for methicillin‐resistant Staphylococcus aureus infections: An umbrella review

Journal of Evidence-Based Medicine, Volume 17, Issue 4, Page 729-739, December 2024.
Abstract Objective To summarize the evidence on the efficacy and safety of vancomycin compared with those of alternative treatments in adult patients with methicillin‐resistant Staphylococcus aureus (MRSA) infection. Methods PubMed, Embase, and Web of Science were searched up to December 15, 2023, for systematic reviews and meta‐analyses comparing ...
Sujata Purja, Minji Kim, Yomna Elghanam, Hae Jung Shim, Eunyoung Kim   +4 more
wiley   +1 more source

Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system

Acta Pharmaceutica
This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between the second ...
Wang Zhu, Gan Guoping, Yao Haiping
doaj   +1 more source

Management of vancomycin‐resistant Enterococci and daptomycin‐resistant Enterococci infections in liver transplant recipients in a single academic center

Transplant Infectious Disease, Volume 26, Issue 6, December 2024.
Vancomycin‐resistant Enterococci infections carry high mortality in liver transplant recipients, especially in the setting of daptomycin resistance. Infection relapsed or recurred in over 25% despite standard‐of‐care therapy. Source control is critical and more data is needed to establish an optimal treatment approach.
Aldo Barajas‐Ochoa, Olivia Hess, Tucker Smith, Matthew Ambrosio, Megan Morales, Idris Yakubu, Lora Thomas, David Bruno, Nicole Vissichelli   +8 more
wiley   +1 more source

Lip necrosis caused by methicillin‐resistant Staphylococcus aureus (MRSA)

JEADV Clinical Practice, Volume 3, Issue 4, Page 1253-1257, September 2024.
Abstract Labial necrosis is a rare condition with diverse causes, posing challenges for diagnosis and treatment. Methicillin‐resistant Staphylococcus aureus (MRSA) strains, particularly those positive for Panton‐Valentine leukocidin (PVL), further complicate management due to antibiotic resistance and heightened virulence.
Saad Khayat, Marc Agea Martínez, Manuel Tousidonis Rial, Alberto Diez Montiel, Santiago Ochandiano Caicoya   +4 more
wiley   +1 more source