Results 101 to 110 of about 2,144 (203)

Omadacycline successfully treated severe Legionella pneumonia after moxifloxacin treatment failure: Case series

Frontiers in Pharmacology
Legionella is a significant pathogen responsible for community-acquired pneumonia and, less commonly, for hospital-acquired pneumonia. Legionella pneumophila, the most prevalent species within the Legionella genus, accounts for 80%–90% of human ...
Biyun Li, Laiyu Liu, Fei Li, Chunmei He, Yuan Chen, Xiaodong Tian, Zhenyu Liu, Weizhen Zhang   +7 more
doaj   +1 more source

The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome

Antibiotics, 2016
Omadacycline is an aminomethylcycline antibiotic with potent activity against many Gram-positive and Gram-negative pathogens, including strains carrying the major efflux and ribosome protection resistance determinants. This makes it a promising candidate
Corina G. Heidrich, Sanya Mitova, Andreas Schedlbauer, Sean R. Connell, Paola Fucini, Judith N. Steenbergen, Christian Berens   +6 more
doaj   +1 more source

Fecal Pharmacokinetics and Gut Microbiome Effects of oral Omadacycline Versus Vancomycin in Healthy Volunteers [PDF]

BACKGROUND: Clostridioides difficile infection (CDI) is a common healthcare-associated infection with limited treatment options. Omadacycline, an aminomethylcycline tetracycline, has potent in vitro activity against C difficile and a low propensity to ...
Agyapong, Samantha, Ayele, Hossaena, Begum, Khurshida, Garey, Kevin W, Gonzales-Luna, Anne J, Hanson, Blake M, Hu, Chenlin, Jahangir Alam, M, Jo, Jinhee, Lancaster, Chris, Le, Thanh M, Wang, Weiqun   +11 more
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The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation [PDF]

The history of clinical resistance to tetracycline antibiotics is characterized by cycles whereby the deployment of a new generation of drug molecules is quickly followed by the discovery of a new mechanism of resistance. This suggests mechanism-specific
Blake, Kevin S, Dantas, Gautam, Fishbein, Skye R S, Gillespie, Vincent J, Tolia, Niraj H, Wencewicz, Timothy A, Xue, Yao-Peng   +6 more
core   +2 more sources

Omadacycline for Diverse Infections in China: A Real-World Analysis of Efficacy and Safety

Infectious Diseases and Therapy
Introduction The efficacy and safety of omadacycline have been primarily documented through Phase III clinical trials; however, there are limited data from real-world clinical settings.
Weiwen Gao, Jian Yang, Xiangwang Zhang, Lei Tian, Dong Xu, Shuyun Xu, Dong Liu, Yan He   +7 more
doaj   +1 more source

Omadacycline for the Treatment of Severe Chlamydia psittaci Pneumonia Complicated with Multiple Organ Failure: A Case Report

Infection and Drug Resistance, 2022
Changquan Fang,1,* Limin Xu,2,* Jiarong Tan,1 Hongyi Tan,1 Junhong Lin,1 Ziwen Zhao3 1Department of Pulmonary and Critical Care Medicine, Huizhou Central People’s Hospital, Huizhou, Guangdong Province, Peoples’ Republic of China; 2Department of ...
Fang C, Xu L, Tan J, Tan H, Lin J, Zhao Z   +5 more
doaj  

Case Report: Deep sternal wound infection caused by Mycoplasma hominis after cardiac surgery [PDF]

Deep sternal wound infection (DSWI) caused by Mycoplasma hominis after cardiac surgery is very rare and easily overlooked. This paper reports the case of a patient with DSWI after cardiac surgery. The patient had an unexplained fever postoperatively.
Lijun Chen, Yong Shi, Yu Chen, Zhaohui Wang   +3 more
core   +1 more source

Emergence of plasmid-borne tet(X4) resistance gene in clinical isolate of eravacycline- and omadacycline-resistant Klebsiella pneumoniae ST485

Microbiology Spectrum
Omadacycline and eravacycline are gradually being used as new tetracycline antibiotics for the clinical treatment of Gram-negative pathogens. Affected by various tetracycline-inactivating enzymes, there have been reports of resistance to eravacycline and
Xiaojing Liu, Yi Liu, Xiaohan Ma, Ruyan Chen, Chenyu Li, Hongxin Fu, Yu Yang, Kexin Guo, Xiaoping Zhang, Ruishan Liu, Hao Xu, Junfei Zhu, Beiwen Zheng   +12 more
doaj   +1 more source

Omadacycline for the treatment of severe pneumonia caused by Chlamydia psittaci complicated with acute respiratory distress syndrome during the COVID-19 pandemic

Frontiers in Medicine
IntroductionChlamydia psittaci infection in humans is a rare cause that mainly present as community-acquired pneumonia. Severe Chlamydia psittaci pneumonia can lead to acute respiratory distress syndrome (ARDS), septic shock, or multiple organ ...
Dao-Xin Wang, Dao-Xin Wang, Ling-Xi Xiao, Ling-Xi Xiao, Xin-Yu Deng, Xin-Yu Deng, Wang Deng, Wang Deng   +7 more
doaj   +1 more source

Susceptibility of multidrug-resistant Escherichia coli and Klebsiella pneumoniae to oral antibiotics in Australia

Journal of Global Antimicrobial Resistance
: Objectives: In Australia, resistance to β-lactam-class antibiotics in Enterobacterales has increased. This study aimed to identify potential oral treatments for these multidrug-resistant infections by investigating four β-lactam (mecillinam, tebipenem,
Bethany Rachel O'Neill, Andrew Ginn, Menuk Jayawardena, Indy Sandaradura   +3 more
doaj   +1 more source