Results 91 to 100 of about 2,144 (203)

Omadacycline: A Modernized Tetracycline

Clinical Infectious Diseases, 2019
AbstractWhen tetracyclines were introduced in the 1940s, these antibiotics offered a broad spectrum of activity against multiple types of pathogens. However, their utility waned after the selection of tetracycline resistance in the pathogens against which they were effective. Omadacycline is a semisynthetic aminomethylcycline antibacterial derived from
openaire   +1 more source

Antimicrobial consumption and resistance in bacteria from humans and food‐producing animals

EFSA Journal, Volume 22, Issue 2, February 2024.
Abstract The fourth joint inter‐agency report on integrated analysis of antimicrobial consumption (AMC) and the occurrence of antimicrobial resistance (AMR) in bacteria from humans and food‐producing animals (JIACRA) addressed data obtained by the Agencies' EU‐wide surveillance networks for 2019–2021.
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA), European Medicines Agency (EMA)   +2 more
wiley   +1 more source

Omadacycline for treatment of Mycobacterium chelonae skin infection

Baylor University Medical Center Proceedings, 2020
Mycobacterium chelonae can be difficult to treat because of inherent resistance to many available antimicrobials. We present a case of a multidrug-resistant M. chelonae skin infection in a 52-year-old woman who presented with a 3- to 4-week history of painful, erythematous nodules on the bilateral lower extremities.
Madeline Frizzell, Emily Carr, Karen Brust   +2 more
openaire   +3 more sources

Omadacycline gut microbiome exposure does not induce Clostridium difficile proliferation or toxin production in a model that simulates the proximal, medial and distal human colon [PDF]

, 2019
A clinically reflective model of the human colon was used to investigate the effects of the broad-spectrum antibiotic omadacycline on the gut microbiome, and subsequent potential to induce simulated Clostridium difficile infection (CDI).
Buckley, AM, Chilton, CH, Clark, E, Ewin, D, Moura, IB, Shearman, S, Wilcox, MH   +6 more
core   +1 more source

Immunomodulatory activity of omadacycline in vitro and in a murine model of acute lung injury

mSphere
Cystic fibrosis (CF) is characterized by chronic airway obstruction, infection, and inflammation leading to progressive loss of lung function and eventual respiratory failure.
Madeline Sanders, Paul Beringer
doaj   +1 more source

Developments for the Treatment of Invasive Infections Due to Multidrug-resistant Acinetobacter baumannii [PDF]

, 2019
Acinetobacter baumannii is a significant pathogen in healthcare settings (specifically prominent in healthcare- and ventilator-associated pneumonia) due primarily to its virulence and resistance to a wide variety of antimicrobial drug classes, including ...
Drew, Richard, Laurent, David, Wilson, Dustin   +2 more
core   +1 more source

Resistance of Gram-Negative Bacteria to Eravacycline: A Systematic Review of Data from In Vitro Studies [PDF]

Introduction: Eravacycline is a new fluorocycline antibiotic with a broad spectrum of antimicrobial activity approved for the treatment of patients with complicated intra-abdominal infections.
Falagas, Matthew E., Filippou, Charalampos, Karageorgopoulos, Drosos E., Kontogiannis, Dimitrios S., Romanos, Laura T.   +4 more
core   +2 more sources

In vitro activity of omadacycline against bacterial isolates from bone/joint infections and rare pathogens in the SENTRY antimicrobial surveillance program (2015–2023)

Journal of Global Antimicrobial Resistance
Objectives: Omadacycline is an aminomethylcycline (tetracycline class) antibacterial approved by the United States Food and Drug Administration (2018) for treatment of adults with acute bacterial skin and skin structure infection (ABSSSI) and community ...
Michael D. Huband, Paul R. Rhomberg, Kelley A. Fedler, Christopher Blankers, Diane Anastasiou, Alisa W. Serio, Mariana Castanheira   +6 more
doaj   +1 more source

PES Pathogens in Severe Community-Acquired Pneumonia [PDF]

, 2019
Worldwide, there is growing concern about the burden of pneumonia. Severe community-acquired pneumonia (CAP) is frequently complicated by pulmonary and extra-pulmonary complications, including sepsis, septic shock, acute respiratory distress syndrome ...
Cillóniz, Catia, Dominedò, Cristina, Nicolini, Antonello, Torres Martí, Antoni   +3 more
core   +1 more source

Pharmacokinetics of Omadacycline in Adults with Cystic Fibrosis

Clinical Pharmacokinetics
Omadacycline offers a potential advancement in the management of infections in people with cystic fibrosis (CF) because of its spectrum of activity, intrapulmonary penetration, and oral bioavailability. A prospective single-dose, single-arm study was conducted to characterize the pharmacokinetic (PK) profile of omadacycline in people with CF ...
Madeline Sanders, Eunjin Hong, Peter S. Chung, Adupa P. Rao, Paul Beringer   +4 more
openaire   +2 more sources