Results 71 to 80 of about 1,785 (194)
Diagnostic Microbiology and Infectious Disease, 2022 This study used surveillance data from a global program of clinical bacterial isolates to determine whether a tetracycline susceptible result can be used to predict an omadacycline susceptible result. Categorical agreement, very major error rates, and minor error rates were calculated for Staphylococcus aureus (MSSA and MRSA; n=38,364), S. lugdunensis (
Alisa W. Serio +3 more
openaire +2 more sources
Polymorphic Clinical and Pathological Presentation of Nontuberculous Mycobacteria: A Case Series
Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.Background Nontuberculous mycobacteria (NTM) are a group of mycobacteria widely distributed in the environment. They may cause cutaneous infections in immunocompromised and immunocompetent hosts. Clinical presentations can be significantly heterogeneous and are not species‐specific; moreover, histological features can vary, probably depending on host ...
Gabriele Biondi +4 more
wiley +1 more source
Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Omadacycline is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae
Michael P, Draper +6 more
openaire +2 more sources
Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT A series of novel tetracycline derivatives were synthesized with the goal of creating new antibiotics that would be unaffected by the known tetracycline resistance mechanisms. New C-9-position derivatives of minocycline (the aminomethylcyclines [AMCs]) were tested for in vitro activity against ...
Honeyman, Laura +12 more
openaire +2 more sources
Psittacosis in Focus: A Review Addressing the Risks and Management Challenges in Outbreak Scenarios
Health Science Reports, Volume 8, Issue 5, May 2025.ABSTRACT Background and Aim Psittacosis is a zoonotic disease that mostly affects birds and can infect people. It causes respiratory ailments that can be minor or severe. The disease's importance to public health is shown by the fact that it has been connected to isolated outbreaks in several parts of the world.
Himel Ghosh +3 more
wiley +1 more source
Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline
, 2017 1. Absorption, distribution, metabolism, transport and elimination properties of omadacycline, an aminomethylcycline antibiotic, were investigated in vitro and in a study in healthy male subjects. 2.
Gu, Helen +17 more
core +1 more source
Respirology Case Reports, Volume 13, Issue 5, May 2025.Here, we report our treatment experience of a patient with critically severe empyema on extracorporeal membrane oxygenation (ECMO) and subsequent complex treatments, ultimately resulting in his recovery. ABSTRACT Empyema is one of the most dangerous complications in thoracic surgery.
Shunxin Xin +6 more
wiley +1 more source
Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14 C-Omadacycline in Rats [PDF]
Antimicrobial Agents and Chemotherapy, 2017 ABSTRACT The absorption, distribution, metabolism, and excretion (ADME) of omadacycline, a first-in-class aminomethylcycline antibiotic with a broad spectrum of activity against Gram-positive, Gram-negative, anaerobic, and atypical bacteria, were evaluated in rats.
Lin, Wen +7 more
openaire +2 more sources
A Randomized, Open-label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects [PDF]
, 2016 Omadacycline is a first in class aminomethylcycline antibiotic with microbiological activity against Gram-positive and Gram-negative aerobes and anaerobes, and atypical bacteria that is being developed for the treatment of acute bacterial skin and skin ...
Kuemmell, Andreas +9 more
core +1 more source
Transplant Infectious Disease, Volume 27, Issue 3, May/June 2025.Posttransplant Mycobacterium abscessus infection occurred in 53% of patients with pretransplant infection. While pretransplant infection itself was not associated with impaired survival, both failure to achieve microbiological eradication before transplant and persistent posttransplant disease were linked to increased mortality.
Roni Bitterman +17 more
wiley +1 more source