Safety evaluation of current therapies for high-risk severely ill patients with carbapenem-resistant infections [PDF]
, 2021 Introduction Infections due to carbapenem-resistant Gram-negative bacteria (CR-GNB) are increasingly frequent events, which are associated with a high mortality rate.
Bassetti, Matteo +4 more
core +1 more source
The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]
, 2017 Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K +11 more
core +3 more sources
New antibiotic development: barriers and opportunities [PDF]
, 2016 Antibiotic resistance represents a serious threat to public health worldwide, leading to increased healthcare costs, prolonged hospital stays, treatment failures and deaths.
Ercole Concia +2 more
core +2 more sources
Nieuwe antibiotica werkzaam tegen multiresistente gramnegatieve bacteriën [PDF]
, 2021 Infecties door gramnegatieve bacteriën zijn lastig te behandelen wanneer deze bacteriën resistent zijn voor β-lactamantibiotica. De afgelopen 5 jaar zijn door het Europees Geneesmiddelenbureau en het Amerikaanse Food and Drug Administration nieuwe ...
Bax, Hannelore +4 more
core
New antibiotics for multidrug-resistant bacterial strains: Latest research developments and future perspectives [PDF]
, 2021 The present work aims to examine the worrying problem of antibiotic resistance and the emergence of multidrug-resistant bacterial strains, which have now become really common in hospitals and risk hindering the global control of infectious diseases ...
Pregnolato M., Taccani M., Terreni M.
core +1 more source
Emerging treatment options for multi-drug-resistant bacterial infections [PDF]
, 2021 Antimicrobial resistance (AMR) remains one of the top public health issues of global concern. Among the most important strategies for AMR control there is the correct and appropriate use of antibiotics, including those available for the treatment of AMR ...
Andini R. +5 more
core +1 more source
Treatment of infections caused by multidrug-resistant Gram-negative bacteria:Report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party [PDF]
, 2018 The Working Party makes more than 100 tabulated recommendations in antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) and suggest further research, and algorithms for hospital and ...
Enoch, David A +6 more
core +1 more source
IGNITE4 : Results of a phase 3, randomized, multicenter, prospective trial of eravacycline vs meropenem in the treatment of complicated intraabdominal infections [PDF]
, 2019 Funding Information: Financial support. This work was supported by Tetraphase Pharmaceuticals Inc. Funding Information: Potential conflicts of interest. J. S. S. has received support from Tetraphase Pharmaceuticals Inc.
Evans, David +6 more
core +1 more source
Clinically Approved Antibiotics from 2010 to 2022 [PDF]
, 2023 This review discusses small molecule antibiotics approved for clinical use in the time frame 2010-2022. This time span saw the approval of four synthetic antibiotics (bedaquiline, pretomanid, delafloxacin, tedizolid), nine natural product derivatives ...
Gademann, Karl, Jung, Erik
core +1 more source
In Vitro Activity of Eravacycline and Comparator Agents Against Bacterial Pathogens Isolated From Patients With Cancer [PDF]
, 2023 BACKGROUND: Bacterial infections are common in patients with cancer, and many bacteria have developed resistance to currently used antibiotics. OBJECTIVES: We evaluated the METHODS: Antimicrobial susceptibility testing was performed using CLSI-approved ...
Gerges, Bahgat +5 more
core +1 more source