Results 51 to 60 of about 2,272 (175)

Standard curves of tetracycline, rifamycin SV, and eravacycline.

, 2021
(A) The standard curve of tetracycline was generated using the reporter strain E. coli ΔtolC treated with E. coli HM22 lysates supplemented with known concentrations of tetracycline. (B) The standard curve of rifamycin SV was generated using the reporter
Karin Sauer (1993), Huan Gu (1918261), Shikha Nangia (1322931), Dacheng Ren (133429), Sweta Roy (11824859), Ali Adem Bahar (11824862)   +5 more
core   +1 more source

Eravacycline infusion–related hypoesthesia: A case report

American Journal of Health-System Pharmacy, 2022
Abstract Purpose Eravacycline (ERV) is often used for drug-resistant gram-negative and nontuberculous mycobacteria (NTM) infections, but infusion site reactions are a potential adverse effect. We report a case of severe hypoesthesia secondary to ERV infusion.
R Briley, Miller, Kinsey M, McClure, Robby G, Stewart, Stephanie C, Shealy, Krishnan, Brown, P Brandon, Bookstaver   +5 more
openaire   +2 more sources

In vitro Antimicrobial Activity and Dose Optimization of Eravacycline and Other Tetracycline Derivatives Against Levofloxacin-Non-Susceptible and/or Trimethoprim-Sulfamethoxazole-Resistant Stenotrophomonas maltophilia

, 2023
Jie Wu,1,2 Guangcun Zhang,3 Qiang Zhao,3 Lifeng Wang,3 Jiyong Yang,3 Junchang Cui1 1Department of Respiratory Diseases, The Eighth Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2Medical School of ...
Zhang G, Wu J, Yang J, Zhao Q, Cui J, Wang L   +5 more
core  

Antibacterial activity of eravacycline against Klebsiella pneumoniae isolates: an in vitro study

Microbiology Spectrum
Eravacycline, a novel tetracycline antibiotic, may be an effective treatment option for Klebsiella pneumoniae infections. We thus conducted an in vitro susceptibility analysis for eravacycline in 211 K. pneumoniae isolates.
Yuanzhi Gong, Yuhao Liu, Yunlou Zhu, Shikui Mu, Hanlu Gao, Xin Jing, Yingying Du, Sheng Wang   +7 more
doaj   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

In vitro and in vivo comparison of eravacycline- and tigecycline-based combination therapies for tigecycline-resistant Acinetobacter baumannii

, 2021
[[abstract]]Several antimicrobial combination therapies are used to treat multiple drug resistant (MDR) and extensively drug resistant (XDR) Acinetobacter baumannii infections.
Yin, T;Lai, JJ;Huang, WC;Kuo, SC;Chiang, TT;Yang, YS;the ACTION study group
core   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Carbapenem Resistance in India: A Systematic Review of Epidemiology, Diagnostic Strategies, and Therapeutic Approaches

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Carbapenem‐resistant gram‐negative infections pose a major public health challenge in India due to high antibiotic consumption, limited diagnostic access, and regional variation in resistance mechanisms. We systematically reviewed recent data to evaluate prevalence, diagnostics, and therapeutic strategies.
Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, Bal Krishna Mishra, Madhu Singh, Rahul Sarode, Vijeta Bajpai, Anil Singh, Sujit Bharti, Anwita Mishra, Ankita Chaurasia, Satyajit Pradhan, Baisakhi Banerjee   +12 more
wiley   +1 more source

Inactivation of efflux pumps sensitized normal cells to eravacycline.

, 2021
The graph shows the CFUs after eravacycline treatment of E. coli BW25113, E. coli BW25113 ΔacrA, E. coli BW25113 ΔtolC, and E. coli BW25113 ΔacrB. Means ± SE are shown (n = 3). (TIF)
Karin Sauer (1993), Huan Gu (1918261), Shikha Nangia (1322931), Dacheng Ren (133429), Sweta Roy (11824859), Ali Adem Bahar (11824862)   +5 more
core   +1 more source