Results 51 to 60 of about 2,050 (152)
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Viability of E. coli HM22 after treatment with rifamycin SV and eravacycline.
, 2021 (A) Effects of 100 μg/mL rifamycin SV on the viability of normal (black bars) and persister (patterned bars) cells of E. coli HM22. Means ± SE are shown (n = 3). (B) Intracellular concentration of rifamycin SV based on the reporter bioassay. Rifamycin SV
Karin Sauer (1993) +5 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer +24 more
wiley +1 more source
, 2022 In this study, we investigated the in vitro activity and resistance mechanisms of the new generation tetracycline agents, namely eravacycline, omadacycline, and tigecycline, against Staphylococcus aureus isolates. A total of 1,017 non-duplicate S. aureus
Yi Zhang (9093) +8 more
core +1 more source
Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection
Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon +9 more
wiley +1 more source
Antibacterial activity of eravacycline against Klebsiella pneumoniae isolates: an in vitro study
Microbiology SpectrumEravacycline, a novel tetracycline antibiotic, may be an effective treatment option for Klebsiella pneumoniae infections. We thus conducted an in vitro susceptibility analysis for eravacycline in 211 K. pneumoniae isolates.
Yuanzhi Gong +7 more
doaj +1 more source
BioMed Research International, Volume 2026, Issue 1, 2026.Acinetobacter baumannii is a globally prevalent Gram‐negative pathogen responsible for a substantial proportion of healthcare‐associated infections, particularly in intensive care units. Its ability to persist in hospital environments, form biofilms on medical devices, and evade host immune responses has contributed to the rapid emergence of multidrug ...
Krupa Bhaliya +7 more
wiley +1 more source
In Silico Pharmacokinetic Profile and Antimalarial Efficacy of 3‐Chloro‐4‐(4‐Chlorophenoxy)Aniline
Biochemistry Research International, Volume 2026, Issue 1, 2026.Despite the urgent need for new therapies to treat multidrug‐resistant virulent Plasmodium falciparum, many promising antimalarial candidates fail to progress to clinical use because their pharmacokinetic (PK) profile is poorly characterized. This study predicted the PK profile of a new compound, 3‐chloro‐4‐(4‐chlorophenoxy)aniline (ANI), in silico ...
Milka W. Waithera +5 more
wiley +1 more source
BMC Infectious Diseases, 2019 Background In China multidrug-resistant bacteria pose a considerable threat to public health. Antimicrobial resistance has weakened the effectiveness of many medicines widely used today.
Chunjiang Zhao +6 more
doaj +1 more source
Microbial Biotechnology, Volume 18, Issue 9, September 2025.Investigation of outer membrane vesicles from Acinetobacter baumannii for potential biotechnological applications. ABSTRACT Outer membrane vesicles (OMVs) are extracellular nanostructures released from Gram‐negative bacteria. Acinetobacter baumannii OMVs (AbOMVs) have been extensively studied and can thus be used as a model for understanding multiple ...
Beatriz Cano‐Castaño +5 more
wiley +1 more source