Results 71 to 80 of about 2,680 (197)

Epidemiology, Treatment, and Outcomes of Gram‐Negative Bacteremia in a Multicenter Cohort of Solid Organ Transplant Recipients

Clinical Transplantation, Volume 39, Issue 4, April 2025.
ABSTRACT Introduction Little is known about the epidemiology and management of gram‐negative bloodstream infections (GN‐BSIs) in patients after solid organ transplant (SOT). We describe epidemiology, treatment approaches, and outcomes in a subset of patients with SOT from a larger cohort with GN‐BSI. Methods This was a multicenter, retrospective cohort
Sarah B. Doernberg, Emily L. Heil, Suiyini Fiawoo, Jae Hyoung Lee, Sara E. Cosgrove, David M. Dobrzynski, Yihan Li, Ryan K. Shields, Emily S. Spivak, Erica J. Stohs, Pranita D. Tamma, Erin K. McCreary   +11 more
wiley   +1 more source

Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults [PDF]

, 2022
Klebsiella pneumoniae; Cefiderocol; Nosocomial pneumoniaKlebsiella pneumoniae; Cefiderocol; Neumonía nosocomialKlebsiella pneumoniae; Cefiderocol; Pneumònia nosocomialInfections due to Klebsiella pneumoniae have been increasing in intensive care units ...
Bou, German, Cantón, Rafael, Díaz, Emili, Ferrer Roca, Ricard, Martin-Loeches, Ignacio, Nuvials Casals, Xavier, Rodríguez, Alejandro, Vidal-Cortés, Pablo   +7 more
core   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Eravacycline for treatment of complicated intra-abdominal infections: the fire is not ignited! [PDF]

Annals of Translational Medicine, 2017
The worldwide surge of multi-drug resistant (MDR) Gram-negative infections has become a real threat in postsurgical and critically ill patients. Among the most dreaded MDR Gram-negatives are extended-spectrum β-lactamase (ESBL) and carbapenemase producing Enterobacteriaceae and MDR Pseudomonas species (1,2). Carbapenem-resistant Enterobacteriaceae (CRE)
Honoré, Patrick M, Spapen, Herbert D
openaire   +2 more sources

Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity In Vitro

Microbiology Spectrum, 2023
The antimicrobial activities of four third-generation tetracycline-class drugs, omadacycline (OMC), eravacycline (ERC), tigecycline (TGC), and sarecycline (SAC), were determined for 193 M. abscessus isolates. The activities of the four drugs at two different temperatures (30°C and 37°C) were also tested.
Anqi Li, Siyuan He, Jingren Li, Zhemin Zhang, Bing Li, Haiqing Chu   +5 more
openaire   +3 more sources

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

The European Medicines Agency Approved the New Antibacterial Drugs – Response to the 2017 Who Report on the Global Problem of Multi-Drug Resistance

Postępy Mikrobiologii, 2021
The growing problem of antimicrobial resistance has been classified by the World Health Organization (WHO) as one of the top ten threats to mankind. In a special report published in 2017, the WHO presented a list of microorganisms for which the search ...
Krajewska Joanna, Laudy Agnieszka Ewa
doaj   +1 more source

Switching Residues: Eine Plattform zur Synthese von Fidaxomicin Antibiotika

Angewandte Chemie, Volume 137, Issue 7, February 10, 2025.
Residue Switching: Das Einführen zusätzlicher Substituenten in Naturstoffe erhöht ihr Molekulargewicht und oft auch ihre Lipophilie. Wir haben ein Pd‐katalysiertes Protokoll entwickelt, um das komplexe Rhamnosid‐Aren‐Fragment des Antibiotikums Fidaxomicin in einem Schritt vom ungeschützten Naturstoff direkt durch einfache Amine zu ersetzen.
Erik Jung, Tizian Griesser, Jordan Costafrolaz, Ondine Duverger, Yves Mattenberger, Silvia Dittmann, Andrea Dorst, Alexander Major, David Dailler, Daniel Schäfle, Susanne Sievers, Konstantin Brodolin, Patrick H. Viollier, Peter Sander, Karl Gademann   +14 more
wiley   +1 more source

Spontaneous bacterial peritonitis due to carbapenemase-producing Enterobacteriaceae: Etiology and antibiotic treatment [PDF]

, 2020
Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gram-negative bacteria.
Alfieri A., Di Franco S., Fiore M., Leone S., Martora F., Pace M. C., Passavanti M. B., Petrou S.   +7 more
core   +1 more source

Eravacycline (TP-434) Is Efficacious in Animal Models of Infection [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT Eravacycline is a novel broad-spectrum fluorocycline antibiotic being developed for a wide range of serious infections. Eravacycline was efficacious in mouse septicemia models, demonstrating 50% protective dose (PD 50 ) values of ≤1 mg/kg of body weight once a day (q.d.) against ...
Trudy H, Grossman, Timothy M, Murphy, Andrew M, Slee, Denene, Lofland, Joyce A, Sutcliffe   +4 more
openaire   +2 more sources