Results 71 to 80 of about 2,050 (152)
Switching Residues: A Platform for the Synthesis of Fidaxomicin Antibiotics
Angewandte Chemie International Edition, Volume 64, Issue 7, February 10, 2025.Switching residues: Adding new substituents to natural products increases their molecular weight and often their lipophilicity. We developed a Pd‐catalysed protocol to directly replace the rhamnoside‐arene fragment of the antibiotic fidaxomicin with simple amines in 1 step from the unprotected natural product.
Erik Jung +14 more
wiley +1 more source
, 2020 Objectives: The approval of new antibiotics is essential to combat infections caused by antimicrobial-resistant pathogens; however, such agents should be tested to determine their effect on the resident microbiota and propensity to select for ...
Ewin, D +9 more
core +1 more source
, 2023 Intravenous (IV) drugs are administered through infusion pumps and IV administration sets for patients who are seen in healthcare settings. There are multiple areas of the medication administration process that can influence the amount of a drug a ...
Michael S. Gelfand +5 more
core +1 more source
Unusual Presentation of Mycobacterium abscessus Thigh Mass: A Case Report
Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.Mycobacterium abscessus is a rapidly growing non‐tuberculous Mycobacterium (NTM) primarily associated with pulmonary infections, particularly in individuals with underlying lung conditions. While soft tissue infections are less common, their incidence has been increasing.
Ryan J. Blake +5 more
wiley +1 more source
Eravacycline is a tetracycline approved for treating intra-abdominal infections caused by multidrug-resistant (MDR) bacteria. Our study aims to compare two methods for determining eravacycline MIC against Gram-negatives and to evaluate its in vitro ...
Montesinos, Maria Isabel +3 more
core +1 more source
, 2019 This study investigated the characteristics and mechanisms of eravacycline resistance and heteroresistance in clinical Klebsiella pneumoniae isolates. A total of 393 clinical K.
Jin-xin Zheng (4876861) +9 more
core +1 more source
Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.Carbapenemases have had increasing prevalence within the United States and worldwide. Here, we present a case of carbapenem‐resistant Klebsiella pneumoniae (CRKP) which is unique due to the rarity of multiple mechanisms of resistance within the Klebsiella pneumoniae harboring New Delhi metallo‐β‐lactamases (NDM), oxacillinase‐48 (OXA‐48)‐like, and ...
Christopher Phan +6 more
wiley +1 more source
iMetaOmics, Volume 1, Issue 2, December 2024.The ramR mutations L58P and F165L weaken the binding between RamR and the ramA promoter, lifting RamR's suppression of ramA expression and resulting in the overexpression of the AcrAB‐TolC and OqxAB efflux pumps. Thus, these mutations enhance Klebsiella pneumoniae's resistance to eravacycline, up to 64‐fold.
Wei Yu +8 more
wiley +1 more source
Carbapenem-resistant Acinetobacter baumannii (CRAB) is resistant to almost all antibiotics. Eravacycline, a newer treatment option, has the potential to treat CRAB infections, however, the mechanism by which CRAB isolates develop resistance to ...
Xian-di Chen (18260341) +10 more
core +1 more source
Public Health Challenges, Volume 3, Issue 4, December 2024.Antimicrobial resistance (AMR) is a major global health issue, especially in low‐ and middle‐income countries (LMICs). This study explores the AMR landscape in 14 LMICs, highlighting barriers to accessing novel Reserve antibiotics, such as affordability, safety and diagnostics.
Fabrizio Motta +12 more
wiley +1 more source