Results 81 to 90 of about 2,272 (175)

DataSheet_1_Emergence of eravacycline heteroresistance in carbapenem-resistant Acinetobacter baumannii isolates in China.docx

Carbapenem-resistant Acinetobacter baumannii (CRAB) is resistant to almost all antibiotics. Eravacycline, a newer treatment option, has the potential to treat CRAB infections, however, the mechanism by which CRAB isolates develop resistance to ...
Xian-di Chen (18260341), Jian-bo Xu (18260353), Shan-wen Lin (18260347), Xiao-hu Wang (10869789), Ming-zhen Wang (18260350), Yi-tan Li (18260338), Chao Zhuo (277585), Zhi-wei Lin (1892365), Guo-hua He (18260356), Ying-yi Guo (18260344), Xi-xi Tan (18260359)   +10 more
core   +1 more source

In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii

, 2016
Eravacycline and comparators were tested against carbapenem- and tigecycline-resistant Enterobacteriaceae and Acinetobacter received at the United Kingdom's national reference laboratory Eravacycline MICs correlated closely with those of tigecycline but ...
Warner, Marina, Livermore, David M., Woodford, Neil, Mushtaq, Shazad   +3 more
core   +1 more source

Eravacycline, a novel tetracycline derivative, does not induce Clostridioides difficile infection in an in vitro human gut model

, 2020
Objectives: The approval of new antibiotics is essential to combat infections caused by antimicrobial-resistant pathogens; however, such agents should be tested to determine their effect on the resident microbiota and propensity to select for ...
Ewin, D, Wilkinson, V, Davis, G, Bently, K, Spittal, W, Buckley, AM, Wilcox, MH, Altringham, J, Moura, IB, Clark, E   +9 more
core   +1 more source

Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae

iMetaOmics, Volume 1, Issue 2, December 2024.
The ramR mutations L58P and F165L weaken the binding between RamR and the ramA promoter, lifting RamR's suppression of ramA expression and resulting in the overexpression of the AcrAB‐TolC and OqxAB efflux pumps. Thus, these mutations enhance Klebsiella pneumoniae's resistance to eravacycline, up to 64‐fold.
Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang   +8 more
wiley   +1 more source

Eravacycline: evaluation of susceptibility testing methods and activity against multidrug-resistant Enterobacterales and Acinetobacter.

Eravacycline is a tetracycline approved for treating intra-abdominal infections caused by multidrug-resistant (MDR) bacteria. Our study aims to compare two methods for determining eravacycline MIC against Gram-negatives and to evaluate its in vitro ...
Montesinos, Maria Isabel, Kinet-Poleur, Amélie, Bogaerts, Pierre, Huang, Daniel   +3 more
core   +1 more source

In vitro and in vivo comparison of eravacycline- and tigecycline-based combination therapies for tigecycline-resistant Acinetobacter baumannii

, 2021
Several antimicrobial combination therapies are used to treat multiple drug resistant (MDR) and extensively drug resistant (XDR) Acinetobacter baumannii infections. A novel antibiotic, eravacycline, shows a higher potency than tigecycline. The efficacies
Tsung-Ta Chiang (11755627), Jiun-Ji Lai (11755624), Ya-Sung Yang (3127113), Wei-Cheng Huang (686204), Ti Yin (11755621), Shu-Chen Kuo (139712)   +5 more
core   +1 more source

C22: Eravacycline versus best previously available therapy in adults with pneumonia due to drug-resistant Acinetobacter baumannii [PDF]

, 2021
There are no published studies documenting outcomes with the use of eravacycline against drug-resistant Acinetobacter baumannii. The purpose of this study is to assess the efficacy of eravacycline use, in comparison to best previously available therapy ...
Zhu, Elizabeth, Jayakumar, Rebecca, Scott, Courtney Jane, Viswesh, Velliyur   +3 more
core  

Residual Infusion Performance Evaluation (RIPE): A Single-Center Evaluation of Residual Volume Post-Intravenous Eravacycline Infusion

, 2023
Intravenous (IV) drugs are administered through infusion pumps and IV administration sets for patients who are seen in healthcare settings. There are multiple areas of the medication administration process that can influence the amount of a drug a ...
Michael S. Gelfand, Kerry O. Cleveland, Nicholson B. Perkins III, Alysa J. Baumann, Angela D. Covington, Athena L. V. Hobbs   +5 more
core   +1 more source

Table_1_The efficacy and safety of eravacycline compared with current clinically common antibiotics in the treatment of adults with complicated intra-abdominal infections: A Bayesian network meta-analysis.DOCX

, 2022
BackgroundEravacycline is a novel, fully synthetic fluorocycline antibiotic for the treatment of adults with complicated intra-abdominal infections (cIAIs).
Mengjie Luo (8780093), Xin Guan (6987), Hongchao Li (1396054), Aixia Ma (500519), Zhengyang Fei (10289495), Lei Sun (45752), Rui Meng (3855607), Yuxin Li (119468)   +7 more
core   +1 more source

Integrative analysis of outer membrane vesicles proteomics and whole-cell transcriptome analysis of eravacycline induced Acinetobacter baumannii strains

BMC Microbiology, 2020
Background Acinetobacter baumannii is a multidrug-resistant (MDR) hazardous bacterium with very high antimicrobial resistance profiles. Outer membrane vesicles (OMVs) help directly and/or indirectly towards antibiotic resistance in these organisms.
DineshKumar Kesavan, Aparna Vasudevan, Liang Wu, Jianguo Chen, Zhaoliang Su, Shengjun Wang, Huaxi Xu   +6 more
doaj   +1 more source