Results 101 to 110 of about 2,680 (197)

In vitro activities of eravacycline against clinical bacterial isolates: a multicenter study in Guangdong, China

Frontiers in Microbiology
IntroductionEravacycline (ERV), a novel tetracycline derivative, exhibits broad-spectrum antibacterial activity, but data on the bacterial activity against Chinese bacterial isolates are very scarce.
Xiaoyan Liao, Qianwen Liang, Xinlu Dai, Shigang Wu, Chaohui Duan, Zhaofan Luo, Xiaoying Xie   +6 more
doaj   +1 more source

Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives [PDF]

Urinary tract infections (UTIs) are the second most frequent type of infection observed in clinical practice. Gram-negative Enterobacteriaceae are common pathogens in UTIs.
Abate M., Arcaniolo D., Aveta A., Barone B., Bologna E., Cilio S., Cirillo L., Crocetto F., Di Filippo I., Di Mauro E., Ditonno F., Franco A., Fusco G. M., La Rocca R., Licari L. C., Manfredi C., Napolitano L., Pandolfo S. D., Passaro F., Pinchera B.   +19 more
core   +1 more source

Novel Tetracyclines Versus Alternative Antibiotics for Treating Acute Bacterial Infection: A Meta-Analysis of Randomized Controlled Trials

Antibiotics, 2019
This meta-analysis assessed the efficacy and safety of novel tetracyclines for treating acute bacterial infections. Data from PubMed, Web of Science, EBSCO, Cochrane databases, Ovid Medline, and Embase databases were accessed until 11 July 2019.
Shao-Huan Lan, Wei-Ting Lin, Shen-Peng Chang, Li-Chin Lu, Chih-Cheng Lai, Jui-Hsiang Wang, Chien-Ming Chao   +6 more
doaj   +1 more source

Unveiling carbapenem resistance: mechanism and therapeutic strategies [PDF]

This review provides an overview of the carbapenem resistance, its underlying causing microbes, its mechanism of transmission, risk factors, and its treatment options and challenges. Carbapenem resistance in Gram-negative organisms such as E. coli and K.
A., Sanjana, H., Fiza S., R., Thanushree D., U., Mounashree   +3 more
core   +2 more sources

Eradication of Pseudomonas aeruginosa Persister Cells by Eravacycline

ACS Infectious Diseases
Pseudomonas aeruginosa is a leading bacterial pathogen that causes persistent infections. One major reason that antibiotics fail to clear such infections is the presence of a dormant subpopulation called persister cells. To eradicate persister cells, it is important to change drug development from traditional strategies that focus on growth inhibition ...
Sweta Roy, Zeynep S. Cakmak, Salma Mahmoud, Mahsa Sadeghzadeh, Guirong Wang, Dacheng Ren   +5 more
openaire   +2 more sources

Preliminary, real-world, multicenter experience with omadacycline for Mycobacterium abscessus infections [PDF]

, 2021
Twelve patients were treated with omadacycline (OMC) as part of a multidrug regimen ...
Alosaimy, Sara, Ansari, Iman, Barger, Melissa L, Bouchard, Jeannette, Cohen, Keira A, Gore, Tristan W, Howard, Catessa, Lagnf, Abdalhamid M, Mejia-Chew, Carlos, Morrisette, Taylor, Philley, Julie V, Rybak, Michael J, Veve, Michael P, Wadle, Carly, Webb, Andrew J   +14 more
core   +2 more sources

New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Liver Transplantation: Clinical Perspectives, Toxicity, and PK/PD Properties [PDF]

Antimicrobial resistance is a growing global health problem, and it is especially relevant among liver transplant recipients where infections, particularly when caused by microorganisms with a difficult-to-treat profile, are a significant cause of ...
Alagna, Laura, Bandera, Alessandra, Lombardi, Andrea, Mangioni, Davide, Palomba, Emanuele, Tonizzo, Anna, Viero, Giulia   +6 more
core   +1 more source

Investigation of the in vitro antimicrobial activity of eravacycline alone and in combination with various antibiotics against MDR Acinetobacter baumanni strains

BMC Microbiology
Background Acinetobacter baumannii is an obligately aerobic, non-motile, non-fermenting, gram-negative, opportunistic pathogen. The fact that this pathogen, which is the leading cause of nosocomial infections, is naturally resistant to many antibiotics ...
Merve Ataman, Berna Özbek Çelik
doaj   +1 more source

Comparative efficacy of eravacycline and tigecycline in addressing multidrug-resistant Gram-negative bacteria

One Health Advances
The rise in antibiotic resistance among Gram-negative bacteria poses significant challenges to global health. This study evaluates the in vitro efficacy of tigecycline, omadacycline, and eravacycline against clinical isolates harboring the mobile ...
Jing Zhang, Hanyu Wang, Aoxiao Chen, Ning Dong, Hongwei Zhou, Kewei Li   +5 more
doaj   +1 more source

Sexually transmitted infections: challenges ahead. [PDF]

, 2017
WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis.
Bradshaw, Catriona S, de Vries, Henry JC, Fairley, Christopher K, Francis, Suzanna C, Hocking, Jane S, Hoornenborg, Elske, Low, Nicola, Mabey, David, Marrazzo, Jeanne M, Peeling, Rosanna W, Philip, Susan S, Schwebke, Jane R, Sonder, Gerard JB, Unemo, Magnus   +13 more
core   +2 more sources