Results 111 to 120 of about 2,680 (197)

Real-World Experience on the Use of Eravacycline at Doses of 1 mg/kg Bodyweight and Fixed Dose Strategy in Two European Tertiary Centers

Antibiotics
Background: Eravaycline is a novel fully synthetic fluorocycline that is currently approved for complicated intra-abdominal infections. However, it is sometimes also used off-label in tertiary care centers for other infection sites as an antibiotic of ...
Karin Oberreiter, Miriam M. Moser, Lisa Schneider, Heinz Burgmann, Chiara Moreal, Simone Giuliano, Jacopo Angelini, Carlo Tascini, Matthias G. Vossen   +8 more
doaj   +1 more source

Emergence of plasmid-borne tet(X4) resistance gene in clinical isolate of eravacycline- and omadacycline-resistant Klebsiella pneumoniae ST485

Microbiology Spectrum
Omadacycline and eravacycline are gradually being used as new tetracycline antibiotics for the clinical treatment of Gram-negative pathogens. Affected by various tetracycline-inactivating enzymes, there have been reports of resistance to eravacycline and
Xiaojing Liu, Yi Liu, Xiaohan Ma, Ruyan Chen, Chenyu Li, Hongxin Fu, Yu Yang, Kexin Guo, Xiaoping Zhang, Ruishan Liu, Hao Xu, Junfei Zhu, Beiwen Zheng   +12 more
doaj   +1 more source

In vitro Antimicrobial Activity and Dose Optimization of Eravacycline and Other Tetracycline Derivatives Against Levofloxacin-Non-Susceptible and/or Trimethoprim-Sulfamethoxazole-Resistant Stenotrophomonas maltophilia

Infection and Drug Resistance, 2023
Jie Wu,1,2 Guangcun Zhang,3 Qiang Zhao,3 Lifeng Wang,3 Jiyong Yang,3 Junchang Cui1 1Department of Respiratory Diseases, The Eighth Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2Medical School of ...
Wu J, Zhang G, Zhao Q, Wang L, Yang J, Cui J   +5 more
doaj  

Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system

Acta Pharmaceutica
This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between the second ...
Wang Zhu, Gan Guoping, Yao Haiping
doaj   +1 more source

Detection and characterization of eravacycline heteroresistance in clinical bacterial isolates

Frontiers in Microbiology
Eravacycline (ERV) has emerged as a therapeutic option for the treatment of carbapenem-resistant pathogens. However, the advent of heteroresistance (HR) to ERV poses a challenge to these therapeutic strategies. This study aimed to investigate ERV HR prevalence among common clinical isolates and further characterize ERV HR in carbapenem-resistant ...
Yingfeng Zhang, Yingfeng Zhang, Dongdong Liu, Yongzhu Liu, Qiwei Li, Hongwei Liu, Peng Zhou, Yaqin Liu, Lili Chen, Weiguo Yin, Yang Lu   +10 more
openaire   +3 more sources

Efficacy and safety of eravacycline versus tigecycline for complicated intra-abdominal infections in the ICU: a multicenter, single-blind, parallel randomized controlled trial study protocol

Frontiers in Medicine
BackgroundComplicated intra-abdominal infections (cIAIs), often caused by multidrug-resistant bacteria such as carbapenem-resistant A. baumannii (CRAB) and carbapenem-resistant Enterobacteriaceae (CRE) are a critical challenge in ICUs.
Jin Jie Liu, Dong Dong Guo, Meng Xing Wang, Yan Zhao Li, Hang Li, Si Bo Liu, Rong Li Yang, Dian Hong Zhang   +7 more
doaj   +1 more source

What every intensivist should know about the management of peritonitis in the intensive care unit [PDF]

, 2018
De Waele, Jan
core   +2 more sources

Efficacy and Safety of Eravacycline Combination Therapy for Carbapenem-Resistant Acinetobacter baumannii Pneumonia in ICU Patients: A Retrospective Study

Infection and Drug Resistance
Qingli Guo,1,* Yifei Wei,2,* Qiongrui Zhao,3 Wenping Zhang,4 Pin Lv,5 Zhimin Zhou,1 Shanmei Wang6 1Department of Clinical Laboratory, Xuchang People’s Hospital, Xuchang, Henan, People’s Republic of China; 2Department of Clinical ...
Guo Q, Wei Y, Zhao Q, Zhang W, Lv P, Zhou Z, Wang S   +6 more
doaj  

Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis [PDF]

Pseudomonas aeruginosa infections are difficult to treat due to rapid development of antibiotic drug resistance. The synergistic combination of already-in-use drugs is an alternative to developing new antibiotics to combat antibiotic-resistant bacteria ...
Cebrián, Rubén, Chen, Jonathan Hon Kwan, de Jong, Anne, Diez-Echave, Patricia, Gao, Peng, García, Federico, Gálvez, Julio, Kao, Richard Yi Tsun, Kuipers, Oscar P., Li, Hongyan, Rodríguez-Nogales, Alba, Rodríguez-Sánchez, María José, Sun, Hongzhe, Wang, Chenyuan, Wei, Xueying, Wu, Weihui, Xia, Yushan   +16 more
core   +1 more source

Evaluation of the in vitro susceptibility of clinical isolates of NDM-producing Klebsiella pneumoniae to new antibiotics included in a treatment regimen for infections

Frontiers in Microbiology
BackgroundDue to the growing resistance to routinely used antibiotics, the search for new antibiotics or their combinations with effective inhibitors against multidrug-resistant microorganisms is ongoing.
Natalia Słabisz, Patrycja Leśnik, Jarosław Janc, Miłosz Fidut, Marzenna Bartoszewicz, Ruth Dudek-Wicher, Urszula Nawrot   +6 more
doaj   +1 more source